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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''FK506-binding protein 3''' is a [[protein]] that in humans is encoded by the ''FKBP3'' [[gene]].<ref name="pmid1374240">{{cite journal | vauthors = Hung DT, Schreiber SL | title = cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein | journal = Biochem. Biophys. Res. Commun. | volume = 184 | issue = 2 | pages = 733–8  | date = Jun 1992 | pmid = 1374240 | pmc =  | doi = 10.1016/0006-291X(92)90651-Z }}</ref><ref name="pmid1532945">{{cite journal | vauthors = Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA | title = Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells | journal = FASEB J. | volume = 6 | issue = 7 | pages = 2482–6  | date = May 1992 | pmid = 1532945 | pmc = | doi = }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_FKBP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pbk.
| PDB = {{PDB2|1pbk}}
| Name = FK506 binding protein 3, 25kDa
| HGNCid = 3719
| Symbol = FKBP3
| AltSymbols =; PPIase; FKBP-25
| OMIM = 186947
| ECnumber = 
| Homologene = 1525
| MGIid = 1353460
| GeneAtlas_image1 = PBB_GE_FKBP3_218003_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003755 |text = peptidyl-prolyl cis-trans isomerase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005528 |text = FK506 binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2287
    | Hs_Ensembl = ENSG00000100442
    | Hs_RefseqProtein = NP_002004
    | Hs_RefseqmRNA = NM_002013
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 44654859
    | Hs_GenLoc_end = 44674272
    | Hs_Uniprot = Q00688
    | Mm_EntrezGene = 30795
    | Mm_Ensembl = ENSMUSG00000020949
    | Mm_RefseqmRNA = NM_013902
    | Mm_RefseqProtein = NP_038930
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 65981037
    | Mm_GenLoc_end = 65992545
    | Mm_Uniprot = Q3UBU9
  }}
}}
'''FK506 binding protein 3, 25kDa''', also known as '''FKBP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2287| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.<ref name="entrez">{{cite web | title = Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2287| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.<ref name="entrez">{{cite web | title = Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2287| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
FKBP3 has been shown to [[Protein-protein interaction|interact]] with [[YY1]],<ref name=pmid11532945>{{cite journal | vauthors = Yang WM, Yao YL, Seto E | title = The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1 | journal = EMBO J. | volume = 20 | issue = 17 | pages = 4814–25  | date = Sep 2001 | pmid = 11532945 | pmc = 125595 | doi = 10.1093/emboj/20.17.4814 }}</ref> [[HDAC1]],<ref name=pmid11532945/> [[Histone deacetylase 2]]<ref name=pmid11532945/>, [[DNA]],<ref name="pmid26762975">{{cite journal |vauthors = Prakash A, Shin J, Rajan S, Yoon HS |title = Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin |journal = Nucleic Acids Res. |volume = 44 |issue = 6 |pages = 2909–25 |year = 2016 |pmid = 26762975 |pmc = 4824100 |doi = 10.1093/nar/gkw001}}</ref> and [[Mdm2]].<ref name=pmid19166840>{{cite journal | vauthors = Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, Milne D, Fuller-Pace F, Meek D | title = FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53 | journal = FEBS Lett. | volume = 583 | issue = 4 | pages = 621–6  | date = Feb 2009 | pmid = 19166840 | doi = 10.1016/j.febslet.2009.01.009 }}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jin YJ, Burakoff SJ, Bierer BE | title = Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25 | journal = J. Biol. Chem. | volume = 267 | issue = 16 | pages = 10942–5 | year = 1992 | pmid = 1375932 | doi =  }}
| citations =
* {{cite journal | vauthors = Wiederrecht G, Martin MM, Sigal NH, Siekierka JJ | title = Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein | journal = Biochem. Biophys. Res. Commun. | volume = 185 | issue = 1 | pages = 298–303 | year = 1992 | pmid = 1376117 | doi = 10.1016/S0006-291X(05)80990-8 }}
*{{cite journal | author=Hung DT, Schreiber SL |title=cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 733-8 |year= 1992 |pmid= 1374240 |doi=  }}
* {{cite journal | vauthors = Jin YJ, Burakoff SJ | title = The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 16 | pages = 7769–73 | year = 1993 | pmid = 7689229 | pmc = 47224 | doi = 10.1073/pnas.90.16.7769 }}
*{{cite journal  | author=Jin YJ, Burakoff SJ, Bierer BE |title=Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10942-5 |year= 1992 |pmid= 1375932 |doi=  }}
* {{cite journal | vauthors = Cross SH, Charlton JA, Nan X, Bird AP | title = Purification of CpG islands using a methylated DNA binding column | journal = Nat. Genet. | volume = 6 | issue = 3 | pages = 236–44 | year = 1994 | pmid = 8012384 | doi = 10.1038/ng0394-236 }}
*{{cite journal | author=Wiederrecht G, Martin MM, Sigal NH, Siekierka JJ |title=Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 1 |pages= 298-303 |year= 1992 |pmid= 1376117 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Jin YJ, Burakoff SJ |title=The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7769-73 |year= 1993 |pmid= 7689229 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236-44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 }}
* {{cite journal | vauthors = Meng X, Chen J, Yang Q, Wang S, Chao Y, Ying K, Xie Y, Mao Y | title = Cloning and identification of a novel cDNA which may be associated with FKBP25 | journal = Biochem. Genet. | volume = 40 | issue = 9-10 | pages = 303–10 | year = 2002 | pmid = 12392168 | doi = 10.1023/A:1020256718720 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Yang WM, Yao YL, Seto E |title=The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1. |journal=EMBO J. |volume=20 |issue= 17 |pages= 4814-25 |year= 2001 |pmid= 11532945 |doi= 10.1093/emboj/20.17.4814 }}
*{{cite journal | author=Meng X, Chen J, Yang Q, ''et al.'' |title=Cloning and identification of a novel cDNA which may be associated with FKBP25. |journal=Biochem. Genet. |volume=40 |issue= 9-10 |pages= 303-10 |year= 2003 |pmid= 12392168 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Won J, Kim M, Yi YW, ''et al.'' |title=A magnetic nanoprobe technology for detecting molecular interactions in live cells. |journal=Science |volume=309 |issue= 5731 |pages= 121-5 |year= 2005 |pmid= 15994554 |doi= 10.1126/science.1112869 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:26, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.[3]

Interactions

FKBP3 has been shown to interact with YY1,[4] HDAC1,[4] Histone deacetylase 2[4], DNA,[5] and Mdm2.[6]

References

  1. ↑ Hung DT, Schreiber SL (Jun 1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein". Biochem. Biophys. Res. Commun. 184 (2): 733–8. doi:10.1016/0006-291X(92)90651-Z. PMID 1374240.
  2. ↑ Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA (May 1992). "Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB J. 6 (7): 2482–6. PMID 1532945.
  3. ↑ 3.0 3.1 "Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa".
  4. ↑ 4.0 4.1 4.2 Yang WM, Yao YL, Seto E (Sep 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
  5. ↑ Prakash A, Shin J, Rajan S, Yoon HS (2016). "Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin". Nucleic Acids Res. 44 (6): 2909–25. doi:10.1093/nar/gkw001. PMC 4824100. PMID 26762975.
  6. ↑ Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, Milne D, Fuller-Pace F, Meek D (Feb 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Lett. 583 (4): 621–6. doi:10.1016/j.febslet.2009.01.009. PMID 19166840.

Further reading

  • Jin YJ, Burakoff SJ, Bierer BE (1992). "Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25". J. Biol. Chem. 267 (16): 10942–5. PMID 1375932.
  • Wiederrecht G, Martin MM, Sigal NH, Siekierka JJ (1992). "Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein". Biochem. Biophys. Res. Commun. 185 (1): 298–303. doi:10.1016/S0006-291X(05)80990-8. PMID 1376117.
  • Jin YJ, Burakoff SJ (1993). "The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7769–73. doi:10.1073/pnas.90.16.7769. PMC 47224. PMID 7689229.
  • Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Meng X, Chen J, Yang Q, Wang S, Chao Y, Ying K, Xie Y, Mao Y (2002). "Cloning and identification of a novel cDNA which may be associated with FKBP25". Biochem. Genet. 40 (9–10): 303–10. doi:10.1023/A:1020256718720. PMID 12392168.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


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