Aplastic anemia laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]] (transfusion-dependent anemia, [[thrombocytopenia]], and severe [[neutropenia]]), a low [[reticulocyte count]], and | Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]] (transfusion-dependent anemia, [[thrombocytopenia]], and severe [[neutropenia]]), a low [[reticulocyte count]], and a normal maturation of all cell lines. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of aplastic anemia include:<ref>{{cite journal|doi=10.1111/j.1365}}</ref> | |||
===Complete Blood Count (CBC)=== | ===Complete Blood Count (CBC)=== | ||
* Decreased [[hemoglobin]] | * Decreased [[hemoglobin]] | ||
* Decreased [[hematocrit]] | * Decreased [[hematocrit]] | ||
* [[Pancytopenia]] ([[anemia]], [[thrombocytopenia]], and severe [[neutropenia]]) | * [[Pancytopenia]] ([[anemia]], [[thrombocytopenia]], and severe [[neutropenia]]) | ||
===Reticulocyte Count=== | ===Reticulocyte Count=== | ||
* | * [[Reticulocytopenia|Reticulocytopenia.]] | ||
=== Peripheral blood smear === | |||
* [[Macrocytosis]] | |||
* [[Poikilocytosis]] | |||
* Small size [[Platelet|platelets]] | |||
===Other tests=== | ===Other tests=== | ||
The following tests should be performed to rule out other conditions: | |||
* [[Renal function]] | * [[Renal function]] | ||
* [[Basic metabolic panel]] | * [[Basic metabolic panel]] |
Revision as of 16:25, 21 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.
Overview
Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia (transfusion-dependent anemia, thrombocytopenia, and severe neutropenia), a low reticulocyte count, and a normal maturation of all cell lines.
Laboratory Findings
Laboratory findings consistent with the diagnosis of aplastic anemia include:[1]
Complete Blood Count (CBC)
- Decreased hemoglobin
- Decreased hematocrit
- Pancytopenia (anemia, thrombocytopenia, and severe neutropenia)
Reticulocyte Count
Peripheral blood smear
- Macrocytosis
- Poikilocytosis
- Small size platelets
Other tests
The following tests should be performed to rule out other conditions:
- Renal function
- Basic metabolic panel
- Liver enzymes
- Thyroid function tests
- Viral studies
- Vitamin B12 and folic acid levels.
Definitive Diagnosis
Bone Marrow Aspiration and Biopsy
- Bone marrow aspiration might be done to find out if and why bone marrow isn't making enough blood cells. For this test, a small amount of bone marrow fluid is aspirated through a needle. The sample is looked at under a microscope to check for faulty cells.
- A bone marrow biopsy might be done at the same time as an aspiration or afterward. For this test, your doctor removes a small amount of bone marrow tissue through a needle. The tissue is checked for the number and types of cells in the bone marrow. In aplastic anemia, the bone marrow has a lower than normal number of all three types of blood cells.
- Bone marrow biopsy (hypoplastic bone marrow (<20% cellularity), and with normal maturation of all cell lines.
References
- ↑ . doi:10.1111/j.1365. Missing or empty
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