Poikilocytosis
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| Poikilocytosis Classification and external resources | |
| ICD-10 | R71. |
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| ICD-9 | 790.09 |
| DiseasesDB | 10207 |
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Overview
Poikilocytosis refers to the presence in the blood of poikilocytes. Poikilocytes are abnormally shaped red blood cells as seen on a blood film. Rather than being seen as a sign of any one disease, poikilocytosis is a rather general condition. There may, however be a predominance of one particular type of abnormally shaped red cells, some of which may indicate possible presence of a specific disease or disorder. [3]
Diagnosis
Normal red blood cells are round, flattened disks that are thinner in the middle than at the edges, whereas a poikilocyte may a distortion of that normal shape, or an entirely different shape. Generally, poikilocytosis can refer to an increase in abnormal red blood cells of any shape where they make up 10% or more of the total population.
Pathology
Causes of poikilocytosis
Abnormal red blood cells are seen in a wide range of conditions, so poikilocytosis is not specific. However, specific types of poikilocytes may be seen in particular disease states and/or disorders.
Membrane Abnormalities
- Acanthocytes or Spur/Spike cells
- Codocytes or Target cells
- Echinocytes and Burr cells
- Elliptocytes and Ovalocytes
- Spherocytes
- Stomatocytes or Mouth cells
Trauma
- Dacrocytes or Teardrop Cells
- Keratocytes
- Microspherocytes and Pyropoikilocytes
- Schistocytes
- Semilunar bodies
Treatment
In all cases, the treatment of poikilocytosis depends on its cause. For example, poikilocytosis can be caused by a vitamin deficiency, in which case the treatment is to take Vitamin B12 or folic acid. It can be caused by a digestive disease, such as celiac disease, in which case the solution may lie in treating the underlying celiac disease so that nutrients can be properly absorbed.
See also
References
Abnormal clinical and laboratory findings (R70-R94, 790-796) | |||||||||||
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| Blood test |
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| Urine test |
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| Other | Abnormal basal metabolic rate - Latent tuberculosis | ||||||||||
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
