Adult T-cell leukemia differential diagnosis: Difference between revisions

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* Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
* Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].


==Differenting Chronic lymphocytic leukemia from other Diseases==
==Differenting Adult T-cell Leukemia from other Diseases==
* Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
* Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
* Based on the expression of cell surface markers, the table below differentiates adult T-cell leukemia from other diseases that cause similar clinical presentations:
* Based on the expression of cell surface markers, the table below differentiates adult T-cell leukemia from other diseases that cause similar clinical presentations:

Revision as of 19:11, 22 January 2016

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Overview

Differenting Adult T-cell Leukemia from other Diseases


Differential Diagnosis Surface Immunoglobulin CD5 CD22/FMC7 CD23 CD79b CD103

Chronic lymphocytic leukemia

Weakly positive

Positive

Negative

Positive

Negative

Positive/Negative

Prolymphocytic leukemia

Strongly positive

Negative

Positive

Negative

Positive

Negative

Hairy cell leukemia

Strongly positive

Negative

Positive

Negative

Positive/Negative

Positive

Mantle cell lymphoma

Positive

Positive

Strongly positive

Negative

Strongly positive

Negative

Follicular lymphoma

Strongly positive

Negative

Positive

Negative

Strongly positive

Negative


  • Adult T-cell leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:[1]

References

  1. Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015

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