Adult T-cell leukemia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]Aida Javanbakht, M.D.

Overview

Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smoldering variant, or an adult T-cell lymphoma variant.

Classification

  • Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or an adult T-cell lymphoma variant.[1][2]
  • The table below lists the adult T-cell leukemia clinical classification details:
Clinical Variant Description
Acute adult T-cell leukemia[3]
[[Chronic adult T-cell leukemia <ref/Marker />]]
[[Primary cutaneous tumoral (PCT)<ref/Marker />]]
  • Cutaneous involvement. Nodules on the skin.
  • Poor prognosis.
  • Normal serum LDH level (or less that twice the normal upper limit)
  • Normal serum calcium level
Smoldering adult T-cell leukemia [1]
Adult T-cell lymphoma [4]

References

  1. 1.0 1.1 Matutes E (2007). "Adult T-cell leukaemia/lymphoma.". J Clin Pathol. 60 (12): 1373–7. PMC 2095573Freely accessible. PMID 18042693. doi:10.1136/jcp.2007.052456. 
  2. Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87).". Br J Haematol. 79 (3): 428–37. PMID 1751370. 
  3. Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T (January 2009). "Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting". J. Clin. Oncol. 27 (3): 453–9. PMC 2737379Freely accessible. PMID 19064971. doi:10.1200/JCO.2008.18.2428. 
  4. Oliveira PD, Farre L, Bittencourt AL (October 2016). "Adult T-cell leukemia/lymphoma". Rev Assoc Med Bras (1992). 62 (7): 691–700. PMID 27925051. doi:10.1590/1806-9282.62.07.691. 

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