Adult T-cell leukemia differential diagnosis

Jump to: navigation, search
Home logo1.png

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

Adult T-cell leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

Differentiating Adult T-cell Leukemia from other Diseases

Differential Diagnosis Surface Immunoglobulin CD5 CD22/FMC7 CD23 CD79b CD103

Chronic lymphocytic leukemia

Weakly positive

Positive

Negative

Positive

Negative

Positive/Negative

Prolymphocytic leukemia

Strongly positive

Negative

Positive

Negative

Positive

Negative

Hairy cell leukemia

Strongly positive

Negative

Positive

Negative

Positive/Negative

Positive

Mantle cell lymphoma

Positive

Positive

Strongly positive

Negative

Strongly positive

Negative

Follicular lymphoma

Strongly positive

Negative

Positive

Negative

Strongly positive

Negative


References

  1. Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015
  2. Chuang SS, Ichinohasama R, Chu JS, Ohshima K (May 2010). "Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/lymphoma". Int. J. Hematol. 91 (4): 687–91. doi:10.1007/s12185-010-0540-x. PMID 20198459.
  3. Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
  4. Rodríguez-Zúñiga M, Cortez-Franco F, Qujiano-Gomero E (June 2018). "Adult T-Cell Leukemia/Lymphoma. Review of the Literature". Actas Dermosifiliogr. 109 (5): 399–407. doi:10.1016/j.ad.2017.08.014. PMID 29685460. Vancouver style error: initials (help)

Linked-in.jpg