Non-Hodgkin lymphoma diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
According to the Ann Arbor staging system, there are four stages of non-Hodgkin lymphoma based on the number of nodes and extra nodal involvement.
Staging
According to the Ann Arbor staging system, there are four stages of non-Hodgkin lymphoma based on the number of nodes and extra nodal involvement.[1] Staging for non-Hodgkin lymphoma is provided in the following table:
| Stage | Involvement | |
|---|---|---|
| stage I | ||
| I | One nodal group or lymphoid organ (e.g. spleen or thymus) | |
| IE | One extra nodal site | |
| stage II | ||
| II | Two or more nodal groups, same side of diaphragm | |
| II E | Localized extra nodal site with stage II criteria, both on the same side of the diaphragm | |
| stage III | ||
| III | Nodal groups on both sides of the diaphragm | |
| III S (1) | With splenic involvement | |
| III E (2) | With localized extra nodal site | |
| III SE | Both | |
| stage IV | ||
| IV | Disseminated involvement of one or more extra lymphatic organ (e.g. lung, bone) +/- any nodal involvement | |
| Additional staging variables | ||
| X | Bulky nodal disease: largest tumor is 10 cm or larger | |
| A | Asymptomatic | |
| B | Presence of B symptoms (fever, night sweats and weight loss) | |
| E | Extra nodal: other than the lymph nodes or spread to tissues beyond, but nearby, the lymphatic tissues | |
| S | Spleen | |
| Limited disease |
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| Advanced disease |
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