Complex locus A1BG and ZNF497: Difference between revisions

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|date=10 December 2019
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/342945
|url=https://www.ncbi.nlm.nih.gov/gene/342945
|accessdate=2019-12-18 }}</ref>
|accessdate=2019-12-18 }}</ref> ZSCAN22 is transcribed in the negative direction from LOC100887072.<ref name=HGNC2019/>
# is MIR6806
# Gene ID: 102465484 is MIR6806.<ref name=HGNCMIR6806>{{ cite web
|author=HGNC2019
|title=MIR6806 microRNA 6806 [ Homo sapiens (human) ]
|publisher=National Center for Biotechnology Information
|location=U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/102465484
|accessdate=2019-12-18 }}</ref> MIR6806 is transcribed in the negative direction from LOC105372480.<ref name=HGNCMIR6806/>


==Alpha-1-B glycoprotein==
==Alpha-1-B glycoprotein==
Line 21: Line 28:
|date=10 December 2019
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/1
|url=https://www.ncbi.nlm.nih.gov/gene/1
|accessdate=2019-12-18 }}</ref> The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some [[immunoglobulin superfamily|immunoglobulin supergene family]] member proteins.  Patients who have pancreatic ductal [[adenocarcinoma]] show an [[overexpression]] of A1BG in [[pancreatic juice]].<ref name="pmid18706098">{{cite journal |vauthors=Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX | title = Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients | journal = BMC Cancer | volume = 8 | issue = | pages = 241 | year = 2008 | pmid = 18706098 | pmc = 2528014 | doi = 10.1186/1471-2407-8-241 }}</ref>
|accessdate=2019-12-18 }}</ref> A1BG is transcribed in the positive direction from ZNF497.<ref name=RefSeqJuly2008/> The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some [[immunoglobulin superfamily|immunoglobulin supergene family]] member proteins.  Patients who have pancreatic ductal [[adenocarcinoma]] show an [[overexpression]] of A1BG in [[pancreatic juice]].<ref name="pmid18706098">{{cite journal |vauthors=Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX | title = Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients | journal = BMC Cancer | volume = 8 | issue = | pages = 241 | year = 2008 | pmid = 18706098 | pmc = 2528014 | doi = 10.1186/1471-2407-8-241 }}</ref> The gene contains 20 distinct [[introns]].<ref name=AceView>{{cite web|title=AceView: A1BG|url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=a1bg&submit=Go|accessdate=May 11, 2013}}</ref>  [[Transcription (genetics)|Transcription]] produces 15 different [[mRNAs]], 10 [[alternatively spliced]] variants and 5 unspliced forms.<ref name="AceView"/>  There are 4 probable alternative [[Promoter (genetics)|promoters]], 4 non overlapping alternative last [[exons]] and 7 validated alternative [[polyadenylation]] sites.<ref name="AceView"/>  The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 4 cassette exons, overlapping exons with different boundaries, splicing versus retention of 3 introns.<ref name="AceView"/>
 
# Gene ID: 503538 is A1BG-AS1 A1BG antisense RNA 1.<ref name=HGNC122019/> A1BG-AS1 is transcribed in the negative direction from ZSCAN22.<ref name=HGNC122019/>
The gene contains 20 distinct [[introns]].<ref name=AceView>{{cite web|title=AceView: A1BG|url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=a1bg&submit=Go|accessdate=May 11, 2013}}</ref>  [[Transcription (genetics)|Transcription]] produces 15 different [[mRNAs]], 10 [[alternatively spliced]] variants and 5 unspliced forms.<ref name="AceView"/>  There are 4 probable alternative [[Promoter (genetics)|promoters]], 4 non overlapping alternative last [[exons]] and 7 validated alternative [[polyadenylation]] sites.<ref name="AceView"/>  The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 4 cassette exons, overlapping exons with different boundaries, splicing versus retention of 3 introns.<ref name="AceView"/>
 
2. A1BG-AS1


==ZNF497==
==ZNF497==


# Gene ID: 162968 is [[ZNF497]] zinc finger protein 497.
# Gene ID: 503538 is [[A1BG-AS1]] A1BG antisense RNA 1.<ref name=HGNC122019>{{ cite web
# is LOC100419840.
|author=HGNC2019
|title=A1BG-AS1 A1BG antisense RNA 1 [ Homo sapiens (human) ]
|publisher=National Center for Biotechnology Information
|location=U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/503538
|accessdate=2019-12-18 }}</ref> A1BG-AS1 is transcribed in the negative direction from ZSCAN22.<ref name=HGNC122019/>
# Gene ID: 162968 is [[ZNF497]] zinc finger protein 497.<ref name=HGNCDec2019>{{ cite web
|author=HGNC2019
|title=ZNF497 zinc finger protein 497 [ Homo sapiens (human) ]
|publisher=National Center for Biotechnology Information
|location=U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/162968
|accessdate=2019-12-18 }}</ref> ZNF497 is transcribed in the positive direction from RNA5SP473.<ref name=HGNCDec2019/>
# Gene ID: 100419840 is LOC100419840 zinc finger protein 446 pseudogene.<ref name=HGNC10Dec2019>{{ cite web
|author=HGNC2019
|title=LOC100419840 zinc finger protein 446 pseudogene [ Homo sapiens (human) ]
|publisher=National Center for Biotechnology Information
|location=U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/100419840
|accessdate=2019-12-18 }}</ref> LOC100419840 may be transcribed in the positive direction from LOC105372483.<ref name=HGNC10Dec2019/>
# Gene ID: 105372483 is LOC105372483 uncharacterized LOC105372483 ncRNA.<ref name=HGNC10-Dec-2019>{{ cite web
|author=HGNC2019
|title=LOC105372483 uncharacterized LOC105372483 [ Homo sapiens (human) ]
|publisher=National Center for Biotechnology Information
|location=U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/105372483
|accessdate=2019-12-18 }}</ref> LOC105372483 is transcribed in the negative direction from A1BG-AS1.<ref name=HGNC10-Dec-2019/>
# Gene ID: 106479017 is RNA5SP473 RNA, 5S ribosomal pseudogene 473.<ref name=RNA5SP473>{{ cite web
|author=HGNC2019
|title=RNA5SP473 RNA, 5S ribosomal pseudogene 473 [ Homo sapiens (human) ]
|publisher=National Center for Biotechnology Information
|location=U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA
|date=10 December 2019
|url=https://www.ncbi.nlm.nih.gov/gene/106479017
|accessdate=2019-12-18 }}</ref> RNA5SP473 may be transcribed in the negative direction from ZNF497.<ref name=RNA5SP473/>


==See also==
==See also==

Revision as of 23:25, 18 December 2019

ZSCAN22

  1. Gene ID: 342945 is ZSCAN22 zinc finger and SCAN domain containing 22.[1] ZSCAN22 is transcribed in the negative direction from LOC100887072.[1]
  2. Gene ID: 102465484 is MIR6806.[2] MIR6806 is transcribed in the negative direction from LOC105372480.[2]

Alpha-1-B glycoprotein

  1. Gene ID: 1 is Alpha-1-B glycoprotein, a 54.3 kDa protein in humans that is encoded by the A1BG gene.[3] A1BG is transcribed in the positive direction from ZNF497.[3] The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. Patients who have pancreatic ductal adenocarcinoma show an overexpression of A1BG in pancreatic juice.[4] The gene contains 20 distinct introns.[5] Transcription produces 15 different mRNAs, 10 alternatively spliced variants and 5 unspliced forms.[5] There are 4 probable alternative promoters, 4 non overlapping alternative last exons and 7 validated alternative polyadenylation sites.[5] The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 4 cassette exons, overlapping exons with different boundaries, splicing versus retention of 3 introns.[5]
  2. Gene ID: 503538 is A1BG-AS1 A1BG antisense RNA 1.[6] A1BG-AS1 is transcribed in the negative direction from ZSCAN22.[6]

ZNF497

  1. Gene ID: 503538 is A1BG-AS1 A1BG antisense RNA 1.[6] A1BG-AS1 is transcribed in the negative direction from ZSCAN22.[6]
  2. Gene ID: 162968 is ZNF497 zinc finger protein 497.[7] ZNF497 is transcribed in the positive direction from RNA5SP473.[7]
  3. Gene ID: 100419840 is LOC100419840 zinc finger protein 446 pseudogene.[8] LOC100419840 may be transcribed in the positive direction from LOC105372483.[8]
  4. Gene ID: 105372483 is LOC105372483 uncharacterized LOC105372483 ncRNA.[9] LOC105372483 is transcribed in the negative direction from A1BG-AS1.[9]
  5. Gene ID: 106479017 is RNA5SP473 RNA, 5S ribosomal pseudogene 473.[10] RNA5SP473 may be transcribed in the negative direction from ZNF497.[10]

See also

References

  1. ↑ 1.0 1.1 HGNC2019 (10 December 2019). "ZSCAN22 zinc finger and SCAN domain containing 22 [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.
  2. ↑ 2.0 2.1 HGNC2019 (10 December 2019). "MIR6806 microRNA 6806 [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.
  3. ↑ 3.0 3.1 RefSeqJuly2008 (10 December 2019). "A1BG alpha-1-B glycoprotein [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.
  4. ↑ Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX (2008). "Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients". BMC Cancer. 8: 241. doi:10.1186/1471-2407-8-241. PMC 2528014. PMID 18706098.
  5. ↑ 5.0 5.1 5.2 5.3 "AceView: A1BG". Retrieved May 11, 2013.
  6. ↑ 6.0 6.1 6.2 6.3 HGNC2019 (10 December 2019). "A1BG-AS1 A1BG antisense RNA 1 [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.
  7. ↑ 7.0 7.1 HGNC2019 (10 December 2019). "ZNF497 zinc finger protein 497 [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.
  8. ↑ 8.0 8.1 HGNC2019 (10 December 2019). "LOC100419840 zinc finger protein 446 pseudogene [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.
  9. ↑ 9.0 9.1 HGNC2019 (10 December 2019). "LOC105372483 uncharacterized LOC105372483 [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.
  10. ↑ 10.0 10.1 HGNC2019 (10 December 2019). "RNA5SP473 RNA, 5S ribosomal pseudogene 473 [ Homo sapiens (human) ]". U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information. Retrieved 2019-12-18.

External links

{{Phosphate biochemistry}}Template:Sisterlinks

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