PTK6: Difference between revisions

Jump to navigation Jump to search
m (Bot: HTTP→HTTPS)
m (1 revision imported)
 
(One intermediate revision by one other user not shown)
Line 29: Line 29:
*{{cite journal  |vauthors=Kamalati T, Jolin HE, Fry MJ, Crompton MR |title=Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation |journal=Oncogene |volume=19 |issue= 48 |pages= 5471–6 |year= 2000 |pmid= 11114724 |doi= 10.1038/sj.onc.1203931 }}
*{{cite journal  |vauthors=Kamalati T, Jolin HE, Fry MJ, Crompton MR |title=Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation |journal=Oncogene |volume=19 |issue= 48 |pages= 5471–6 |year= 2000 |pmid= 11114724 |doi= 10.1038/sj.onc.1203931 }}
*{{cite journal  |vauthors=Hong E, Shin J, Bang E, etal |title=Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain |journal=J. Biomol. NMR |volume=19 |issue= 3 |pages= 291–2 |year= 2001 |pmid= 11330822 |doi=10.1023/A:1011221125013  }}
*{{cite journal  |vauthors=Hong E, Shin J, Bang E, etal |title=Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain |journal=J. Biomol. NMR |volume=19 |issue= 3 |pages= 291–2 |year= 2001 |pmid= 11330822 |doi=10.1023/A:1011221125013  }}
*{{cite journal  |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D }}
*{{cite journal  |vauthors=Kang KN, Kim M, Pae KM, Lee ST |title=Characterization of the 5'-flanking region of the human PTK6 gene |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 365–9 |year= 2002 |pmid= 11997104 |doi=  10.1016/s0167-4781(02)00234-8}}
*{{cite journal  |vauthors=Kang KN, Kim M, Pae KM, Lee ST |title=Characterization of the 5'-flanking region of the human PTK6 gene |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 365–9 |year= 2002 |pmid= 11997104 |doi=  10.1016/s0167-4781(02)00234-8}}
*{{cite journal  |vauthors=Qiu H, Miller WT |title=Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34634–41 |year= 2002 |pmid= 12121988 |doi= 10.1074/jbc.M203877200 }}
*{{cite journal  |vauthors=Qiu H, Miller WT |title=Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34634–41 |year= 2002 |pmid= 12121988 |doi= 10.1074/jbc.M203877200 }}
*{{cite journal  |vauthors=Koo BK, Kim MH, Lee ST, Lee W |title=Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 3 |pages= 343–7 |year= 2002 |pmid= 12297019 |doi=10.5483/BMBRep.2002.35.3.343  }}
*{{cite journal  |vauthors=Koo BK, Kim MH, Lee ST, Lee W |title=Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 3 |pages= 343–7 |year= 2002 |pmid= 12297019 |doi=10.5483/BMBRep.2002.35.3.343  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Coyle JH, Guzik BW, Bor YC, etal |title=Sam68 Enhances the Cytoplasmic Utilization of Intron-Containing RNA and Is Functionally Regulated by the Nuclear Kinase Sik/BRK |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 92–103 |year= 2003 |pmid= 12482964 |doi=10.1128/MCB.23.1.92-103.2003  | pmc=140664  }}
*{{cite journal  |vauthors=Coyle JH, Guzik BW, Bor YC, etal |title=Sam68 Enhances the Cytoplasmic Utilization of Intron-Containing RNA and Is Functionally Regulated by the Nuclear Kinase Sik/BRK |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 92–103 |year= 2003 |pmid= 12482964 |doi=10.1128/MCB.23.1.92-103.2003  | pmc=140664  }}
*{{cite journal  |vauthors=Derry JJ, Prins GS, Ray V, Tyner AL |title=Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells |journal=Oncogene |volume=22 |issue= 27 |pages= 4212–20 |year= 2003 |pmid= 12833144 |doi= 10.1038/sj.onc.1206465 }}
*{{cite journal  |vauthors=Derry JJ, Prins GS, Ray V, Tyner AL |title=Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells |journal=Oncogene |volume=22 |issue= 27 |pages= 4212–20 |year= 2003 |pmid= 12833144 |doi= 10.1038/sj.onc.1206465 }}

Latest revision as of 07:15, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[1][2][3]

Function

Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[3]

Clinical significance

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[3]

Interactions

PTK6 has been shown to interact with STAP2[4] and KHDRBS1.[5]

References

  1. Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.
  2. Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935.
  3. 3.0 3.1 3.2 "Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6".
  4. Mitchell, P J; Sara E A; Crompton M R (August 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. ENGLAND. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. ISSN 0950-9232. PMID 10980601.
  5. Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. UNITED STATES. 20 (16): 6114–26. doi:10.1128/MCB.20.16.6114-6126.2000. ISSN 0270-7306. PMC 86087. PMID 10913193.

Further reading