Leukocyte receptor tyrosine kinase

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.

Function

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown. Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

LTK has been shown to interact with IRS-1, Shc, and PIK3R1.

Further reading

• Krolewski JJ, Dalla-Favera R (1991). "The ltk gene encodes a novel receptor-type protein tyrosine kinase". EMBO J. 10 (10): 2911–9. PMC 453005. PMID 1655406.
• Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277–82. PMID 2156206.
• Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain". Nature. 333 (6174): 672–6. doi:10.1038/333672a0. PMID 2836739.
• Toyoshima H, Kozutsumi H, Maru Y, Hagiwara K, Furuya A, Mioh H, Hanai N, Takaku F, Yazaki Y, Hirai H (1993). "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. doi:10.1073/pnas.90.12.5404. PMC 46728. PMID 7685902.
• Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C (1995). "Regional localization of human chromosome 15 loci". Genomics. 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890.
• Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.
• Kozutsumi H, Toyoshima H, Hagiwara K, Furuya A, Mioh H, Hanai N, Yazaki Y, Hirai H (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines". Biochem. Biophys. Res. Commun. 190 (2): 674–9. doi:10.1006/bbrc.1993.1101. PMID 8427607.
• Ueno H, Sasaki K, Kozutsumi H, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase". J. Biol. Chem. 271 (44): 27707–14. doi:10.1074/jbc.271.44.27707. PMID 8910363.
• Snijders AJ, Ho SC, Haase VH, Pillai S, Bernards A (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin". J. Biol. Chem. 272 (2): 1297–301. doi:10.1074/jbc.272.2.1297. PMID 8995435.
• Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.
• Espanel X, Huguenin-Reggiani M, Hooft van Huijsduijnen R (2003). "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities". Protein Sci. 11 (10): 2326–34. doi:10.1110/ps.0213402. PMC 2373693. PMID 12237455.
• Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus". Hum. Mol. Genet. 13 (2): 171–9. doi:10.1093/hmg/ddh020. PMID 14695357.