Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.[1][2][3]
The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.[1][2]
Function
The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the c-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.[3][4]
Its suppressive role on melanoma development has been reported recently.[5]
↑ 1.01.1Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID9734811.
↑ 2.02.1Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). "Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization". Journal of Human Genetics. 44 (2): 141–2. doi:10.1007/s100380050130. PMID10083745.
↑Gagnon KB, England R, Diehl L, Delpire E (May 2007). "Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation". American Journal of Physiology. Cell Physiology. 292 (5): C1809. doi:10.1152/ajpcell.00580.2006. PMID17267545.
Further reading
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID12168954.
Raghunath M, Patti R, Bannerman P, Lee CM, Baker S, Sutton LN, Phillips PC, Damodar Reddy C (May 2000). "A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line". Brain Research. Molecular Brain Research. 77 (2): 151–62. doi:10.1016/S0169-328X(00)00048-6. PMID10837911.
Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T, Yano R (Apr 2003). "Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain". Brain Research. Molecular Brain Research. 112 (1–2): 103–12. doi:10.1016/S0169-328X(03)00054-8. PMID12670708.
Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K, Saito T, Satoh T, Itoh H, Kaziro Y, Kishimoto T, Hisanaga S (Oct 2003). "Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein". Biochemical and Biophysical Research Communications. 310 (2): 398–404. doi:10.1016/j.bbrc.2003.08.143. PMID14521924.
Piechotta K, Garbarini N, England R, Delpire E (Dec 2003). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase". The Journal of Biological Chemistry. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID14563843.
