Silver sulfadiazine
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| Silver sulfadiazine | |
|---|---|
| |
| Other names | (4-amino-N-2-pyrimidinylbenzenesulfonamidato-NN,01)-silver, sulfadiazine silver, silver (I) sulfadiazine, 4-amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt, dermazine, geben, silvadene |
| Identifiers | |
| CAS number | |
| Properties | |
| Molecular formula | C10H9AgN4O2S |
| Molar mass | 357.14 g/mol |
| Appearance | Solid |
| Melting point |
285 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
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Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. The cream is kept applied to the burned skin at all times, for the duration of the healing period or until a graft is applied. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin. Silver sulfadiazine is typically delivered in a 1% solution suspended in a water-soluble base. The chemical itself is poorly soluble, and has only very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally a problem.
It is also helpful on other shallow, large-area wounds such as abrasions.
A well-known proprietary brand name is Silvadene. The medication is also marketed under Kendall as Thermazene, with the aforementioned silvadene still functioning as a genericized trademark.
Possible side effects
- Areas of dead skin
- Burning sensation
- Red and raised rash on the body
- Skin discoloration
See also
Antibiotics and chemotherapeutics for dermatological use (D06) | |
|---|---|
| Antibiotics: tetracycline and derivatives | Demeclocycline - Chlortetracycline - Oxytetracycline - Tetracycline |
| Antibiotics: other | Fusidic acid - Chloramphenicol - Neomycin - Bacitracin - Gentamicin - Tyrothricin - Mupirocin - Nadifloxacin - Virginiamycin - Rifaximin - Amikacin |
| Chemotherapeutics: sulfonamides | Silver sulfadiazine - Sulfathiazole - Mafenide - Sulfamethizole - Sulfanilamide - Sulfamerazine |
| Chemotherapeutics: antivirals | Idoxuridine - Tromantadine - Aciclovir - Podophyllotoxin - Inosine - Penciclovir - Lysozyme - Ibacitabine - Edoxudine - Imiquimod - Docosanol |
| Chemotherapeutics: other | Metronidazole |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
