Sarcospan
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| sarcospan
| |
| Identifiers | |
| Symbol | SSPN |
| Entrez | 8082 |
| HUGO | 11322 |
| OMIM | 601599 |
| Other data | |
| Locus | Chr. 12 p11.2 |
Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.[1] Loss of sarcospan expression occurs in patients with Duchenne muscular dystrophy, indicating that dystrophin is required for proper localization of sarcospan.[1] Interestingly, sarcospan knockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.[2]
References
- ↑ 1.0 1.1 Crosbie et al (1997). "Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex". J Biol Chem 272 (50): 31221-4. PMID 9395445.
- ↑ Lebakken et al (2000). "Sarcospan-deficient mice maintain normal muscle function.". Mol Cell Biol 20 (5): 1669-77. PMID 10669744.
External links
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