Pott's disease natural history, complications and prognosis

Jump to: navigation, search

Pott's disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pott's Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Pott's disease natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Pott's disease natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Pott's disease natural history, complications and prognosis

CDC on Pott's disease natural history, complications and prognosis

Pott's disease natural history, complications and prognosis in the news

Blogs on Pott's disease natural history, complications and prognosis

Directions to Hospitals Treating Pott's disease

Risk calculators and risk factors for Pott's disease natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hardik Patel, M.D.; Aravind Kuchkuntla, M.B.B.S[2]

Overview

Pott's disease may be complicated by severe vertebral deformity and collapse resulting in kyphosis, cord compression, and paraplegia. It responds well to treatment with improvement of the neurological function and spinal deformity.

Natural History

Spinal tuberculosis is one of the common extra-pulmonary manifestation involving the skeletal system. The common affected sites include the upper lumbar and lower thoracic spine. The infection affects the body of the vertebra or the the intervertebral discs. The progression of the disease is slow with a wide variation in the time of infection to manifest the clinical symptoms of the disease . The average disease duration ranges from 4 to 11 months. Patients take medical help when they develop severe pain, marked deformity or neurological symptoms.[1][2]

Complications

The destruction of the intervertebral disc, body of the vertebra and spread of the infection can result the following complications:[1][3][4]

Prognosis

Pott's disease responds well to treatment with antitubercular treatment. Improvement in pain and neurological deficits are indicators for response to treatment. Prognosis is good in all patients, if a lack of improvement persists other differential must be considered. If other differentials are ruled out and medical therapy is not successful surgery is considered and it has good prognosis.[6]

References

  1. 1.0 1.1 Kumar K (2016). "Spinal tuberculosis, natural history of disease, classifications and principles of management with historical perspective". Eur J Orthop Surg Traumatol. 26 (6): 551–8. doi:10.1007/s00590-016-1811-x. PMID 27435619.
  2. Ratnappuli A, Collinson S, Gaspar-García E, Richardson L, Bernard J, Macallan D (2015). "Pott's disease in twenty-first century London: spinal tuberculosis as a continuing cause of morbidity and mortality". Int J Tuberc Lung Dis. 19 (9): 1125, i–ii. doi:10.5588/ijtld.15.0091. PMID 26260836.
  3. Liu C, Lin L, Wang W, Lv G, Deng Y (2016). "Long-term outcomes of vertebral column resection for kyphosis in patients with cured spinal tuberculosis: average 8-year follow-up". J Neurosurg Spine. 24 (5): 777–85. doi:10.3171/2015.8.SPINE15534. PMID 26745350.
  4. Batirel A, Erdem H, Sengoz G, Pehlivanoglu F, Ramosaco E, Gülsün S; et al. (2015). "The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study". Clin Microbiol Infect. 21 (11): 1008.e9–1008.e18. doi:10.1016/j.cmi.2015.07.013. PMID 26232534.
  5. de Araújo GC, Ferreira Junior Dde S, Escarso Junior Lda R, Gameiro VS (2014). "Spinal tuberculosis presenting with hip abscesses: a diagnostic challenge". BMJ Case Rep. 2014. doi:10.1136/bcr-2014-205569. PMC 4173196. PMID 25253485.
  6. Patankar AP (2016). "Tuberculosis of spine: An experience of 30 cases over two years". Asian J Neurosurg. 11 (3): 226–31. doi:10.4103/1793-5482.145085. PMC 4849291. PMID 27366249.



Linked-in.jpg