Pott's disease pathophysiology

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Pott's disease Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hardik Patel, M.D.; Aravind Kuchkuntla, M.B.B.S[2]

Overview

Pott's disease occurs usually due to hematogenous spread of tuberculous infection from an extraspinal source. Pott's disease usually involves more than one vertebra and manifests as a combination of osteomyelitis and arthritis.

Pathophysiology

Source of infection

Mode of Spread

Pathogenesis

Genetics

Microscopic Pathology

References

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  2. Cooper C, Fellner R, Heubi O, Maixner F, Zink A, Lösch S (2016). "Tuberculosis in early medieval Switzerland--osteological and molecular evidence". Swiss Med Wkly. 146: w14269. doi:10.4414/smw.2016.14269. PMID 26826871.
  3. Batirel A, Erdem H, Sengoz G, Pehlivanoglu F, Ramosaco E, Gülsün S; et al. (2015). "The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study". Clin Microbiol Infect. 21 (11): 1008.e9–1008.e18. doi:10.1016/j.cmi.2015.07.013. PMID 26232534.
  4. Formica M, Cavagnaro L, Formica C (2015). "Pott disease". Spine J. 15 (3): 556–7. doi:10.1016/j.spinee.2014.11.006. PMID 25459741.
  5. Kim JH, Kim SH, Choi JI, Lim DJ (2014). "Atypical noncontiguous multiple spinal tuberculosis: a case report". Korean J Spine. 11 (2): 77–80. doi:10.14245/kjs.2014.11.2.77. PMC 4124923. PMID 25110488.
  6. 6.0 6.1 6.2 Ekinci S, Tatar O, Akpancar S, Bilgic S, Ersen O (2015). "Spinal Tuberculosis". J Exp Neurosci. 9: 89–90. doi:10.4137/JEN.S32842. PMC 4644140. PMID 26609247.
  7. 7.0 7.1 Kilborn T, Janse van Rensburg P, Candy S (2015). "Pediatric and adult spinal tuberculosis: imaging and pathophysiology". Neuroimaging Clin N Am. 25 (2): 209–31. doi:10.1016/j.nic.2015.01.002. PMID 25952174.
  8. Tin SS, Wiwanitkit V (2014). "Noncontiguous multiple spinal tuberculosis". Korean J Spine. 11 (4): 259. doi:10.14245/kjs.2014.11.4.259. PMC 4303286. PMID 25620992.
  9. Shim HK, Cho HL, Lee SH (2014). "Spinal tuberculosis at the posterior element of spinal column: case report". Clin Neurol Neurosurg. 124: 146–50. doi:10.1016/j.clineuro.2014.05.021. PMID 25051165.
  10. Zhang HQ, Deng A, Guo CF, Wang YX, Chen LQ, Wang YF; et al. (2010). "Association between FokI polymorphism in vitamin D receptor gene and susceptibility to spinal tuberculosis in Chinese Han population". Arch Med Res. 41 (1): 46–9. doi:10.1016/j.arcmed.2009.12.004. PMID 20430254.
  11. Panwar A, Garg RK, Malhotra HS, Jain A, Singh AK, Prakash S; et al. (2016). "25-Hydroxy Vitamin D, Vitamin D Receptor and Toll-like Receptor 2 Polymorphisms in Spinal Tuberculosis: A Case-Control Study". Medicine (Baltimore). 95 (17): e3418. doi:10.1097/MD.0000000000003418. PMC 4998689. PMID 27124026.

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