Papillary thyroid cancer biopsy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

On biopsy, papillary thyroid cancer is characterized by trabecular, solid, follicular tumor cells that invade tumor capsule or surrounding vascular structures.

Key Biopsy Findings in Follicular Thyroid Cancer

  • Characteristic Orphan Annie eye nuclear inclusions (nuclei with uniform staining, which appear empty)[1] and psammoma bodies on light microscopy. The former is useful in identifying the follicular variant of papillary thyroid carcinomas.[2]
  • Histologically papillary carcinoma demonstrates 'delicate stalks of epithelial cells' which account for its name.

Reference

  1. "Papillary Carcinoma of Thyroid (Hi Pow)". University of Connecticut Health Center. Retrieved 2008-09-14.
  2. Yang GC, Liebeskind D, Messina AV (2001). "Ultrasound-guided fine-needle aspiration of the thyroid assessed by Ultrafast Papanicolaou stain: data from 1135 biopsies with a two- to six-year follow-up". Thyroid. 11 (6): 581–89. doi:10.1089/105072501750302895. PMID 11442006.

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