Papillary thyroid cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Ammu Susheela, M.D. [3]

Overview

Papillary thyroid cancer may be classified according to histological subtypes. The most common subtypes include conventional, follicular and tall cell form.

Classification

  • WHO classification of papillary thyroid cancer is as follows:[1]
    • Papillary microcarcinoma (<1 cm)
    • Encapsulated
    • Follicular
    • Diffuse sclerosing
    • Tall cell
    • Columnar cell
    • Cribriform-morular APC
    • Hobnail (micropapillary/discohesive)
    • Fibromatosis/ Fasciitis-like stroma
    • Solid/Trabecular
    • Oncocytic
    • Spindle cell
    • Clear cell
    • Warthin-like
  • Another classification system for papillary thyroid cancer is:[2]
    • Conventional
    • Follicular variant
    • Papillary microcarcinoma
    • Tall cell
    • Oncocytic
    • Columnar cell
    • Diffuse sclerosing
    • Solid
    • Clear cell
    • Cribriform morular
    • Macrofollicular
    • PTC with prominent hobnail features
    • PTC with fasciitis-like stroma
    • Combined papillary and medullary carcinoma
    • PTC with dedifferentiation to anaplastic carcinoma
  • The most common subtypes are:
    • Conventional
    • Follicular
    • Tall cell

Reference

  1. Kakudo, Kennichi; Bychkov, Andrey; Bai, Yanhua; Li, Yaqiong; Liu, Zhiyan; Jung, Chan Kwon (2018). "The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives". Pathology International. doi:10.1111/pin.12737. ISSN 1320-5463.
  2. Lloyd, Ricardo V.; Buehler, Darya; Khanafshar, Elham (2011). "Papillary Thyroid Carcinoma Variants". Head and Neck Pathology. 5 (1): 51–56. doi:10.1007/s12105-010-0236-9. ISSN 1936-055X.

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