GTP cyclohydrolase I

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GTP cyclohydrolase 1
Identifiers
Symbol GCH1
Alt. Symbols GCH, DYT5
Entrez 2643
HUGO 4193
OMIM 600225
RefSeq NM_000161
UniProt P30793
Other data
EC number 3.5.4.16
Locus Chr. 14 q22.1-22.2

GTP cyclohydrolase I (GTP 7,8-8,9-dihydrolase, EC 3.5.4.16) is an enzyme that is part of the folate and biopterin biosynthesis pathways. It is responsible for the hydrolysis of guanosine triphosphate (GTP) to form 7,8-dihydroneopterin 3'-triphosphate.

File:GTP-cyclohydrolase-reaction.png
The reaction performed by GTP cyclohydrolase I. The important carbons relative to the transformation are numbered for reference.

References

External links

de:GTP cyclohydrolase I

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