Eye development

Jump to navigation Jump to search
Transverse section showing the lens and the optic cup.

WikiDoc Resources for Eye development

Articles

Most recent articles on Eye development

Most cited articles on Eye development

Review articles on Eye development

Articles on Eye development in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Eye development

Images of Eye development

Photos of Eye development

Podcasts & MP3s on Eye development

Videos on Eye development

Evidence Based Medicine

Cochrane Collaboration on Eye development

Bandolier on Eye development

TRIP on Eye development

Clinical Trials

Ongoing Trials on Eye development at Clinical Trials.gov

Trial results on Eye development

Clinical Trials on Eye development at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Eye development

NICE Guidance on Eye development

NHS PRODIGY Guidance

FDA on Eye development

CDC on Eye development

Books

Books on Eye development

News

Eye development in the news

Be alerted to news on Eye development

News trends on Eye development

Commentary

Blogs on Eye development

Definitions

Definitions of Eye development

Patient Resources / Community

Patient resources on Eye development

Discussion groups on Eye development

Patient Handouts on Eye development

Directions to Hospitals Treating Eye development

Risk calculators and risk factors for Eye development

Healthcare Provider Resources

Symptoms of Eye development

Causes & Risk Factors for Eye development

Diagnostic studies for Eye development

Treatment of Eye development

Continuing Medical Education (CME)

CME Programs on Eye development

International

Eye development en Espanol

Eye development en Francais

Business

Eye development in the Marketplace

Patents on Eye development

Experimental / Informatics

List of terms related to Eye development


Overview

The eye develops from the neural tube, the epidermis, and the periocular mesenchyme, which receives contributions from both the neural crest and mesoderm lineages.

Sequential inductions

This development is an example of sequential inductions where the organ is formed from three different tissues.

First, there is an outpocketing of the neural tube called optic vesicles. The optic vesicles come into contact with the epidermis and induce the epidermis. The epidermis thickens to form the lens placode.

The lens differientiates and invaginates until it pinches off from the epidermis. The lens acts as an inducer back to the optic vesicle to transform it into the optic cup and back to the epidermis to transform it into the cornea.

The optic cup then delaminates into two layers: The neural retina and the retinal pigment epithelium.

The periocular mesenchyme migrates in during the formation of the optic cup and is critical for the induction of the retinal pigment epithelium and the optic nerve. The mesenchyme contributes to the cornea, iris , ciliary body, sclera and blood vessels of the eye.

Responsivity of head epidermis

Only the epidermis in the head is competent to respond to the signal from the optic vesicles. Both the optic vesicle and the head epidermis are required for eye development. The competence of the head epidermis to respond to the optic vesicle signals comes from the expression of Pax6 in the epidermis. Pax6 is necessary and sufficient for eye induction. This competenece is acquired gradually during gastrulation and neurulation from interactions with the endoderm, mesoderm, and neural plate.

Regulation and inhibition

Sonic hedgehog reduces the expression of Pax6. When Shh is inhibited during development, the domain of expression for Pax6 is expanded and the eyes fail to separate causing cyclopia. Overexpression of Shh causes a loss of eye structures.

Template:Developmental biology Template:Development of nervous system


Template:WH

Template:WS