Cryoprecipitate
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
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Cryoprecipitate is a blood product prepared from plasma. Each 15 mL unit contains about 100 U of factor VIII, 250* mg of fibrinogen, von Willebrand factor, factor XIII, and fibronectin.
- NOTE: - Standards state that there has to be a minimum of 150 mg of fibrinogen per bag of cryo, however most bags have around 250 mg (the number used in many calculations).
- There has to be a minimum of 80 IU of factor VIII.
Indications for giving cryoprecipitate include:
- Haemophilia- Used for emergency back up when factor concentrates are not available.
- von Willebrands's disease
- hypofibrinogenaemia (low fibrinogen levels), as can occur with massive transfusions
- bleeding from excessive anticoagulation- Plasma contains most of the coagulation factors, and is a much better choice when anticoagulation has to be quickly reversed.
- massive haemorrhage- RBCs and volume expanders are much better choices for this.
- disseminated intravascular coagulation
References
- Erber WN, Perry DJ (2006) Plasma and plasma products in the treatment of massive haemorrhage. Best Pract Res Clin Haematol 19(1):97-112. PMID 16377544
Transfusion medicine | |
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| General concepts | Apheresis (Plasmapheresis, Plateletpheresis, Leukapheresis) - Blood transfusion - Coombs test - Cross-matching - Exchange transfusion - International Society of Blood Transfusion - Intraoperative blood salvage - ISBT 128 - Transfusion reactions |
| Human blood group systems - Blood type | ABO - Chido-Rodgers - Colton - Cromer - Diego - Dombrock - Duffy - Gerbich - GIL - Hh - Ii - Indian - JMH - Kell (Xk) - Kidd - Knops - LW - Lewis - Lutheran - MNS - OK - P - Raph - Rh - Scianna - T-Tn - Xg - Yt - Other |
| Blood products | Blood donation - Blood substitutes - Cryoprecipitate - Platelets - Plasma - Red blood cells - Whole blood |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

