Complement component 4

complement component 4A (Rodgers blood group)
Identifiers
Symbol	C4A
Entrez	720
HUGO	1323
OMIM	120810
RefSeq	NM_007293
UniProt	P0C0L4
Other data
Locus	Chr. 6 p21.3

Classical pathway. (Some labels are in Polish.)

complement component 4B (Childo blood group)
Identifiers
Symbol	C4B
Entrez	721
HUGO	1324
OMIM	120820
RefSeq	NM_000592
UniProt	P0C0L5
Other data
Locus	Chr. 6 p21.3

WikiDoc Resources for Complement component 4
Articles
Most recent articles on Complement component 4 Most cited articles on Complement component 4 Review articles on Complement component 4 Articles on Complement component 4 in N Eng J Med, Lancet, BMJ
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Evidence Based Medicine
Cochrane Collaboration on Complement component 4 Bandolier on Complement component 4 TRIP on Complement component 4
Clinical Trials
Ongoing Trials on Complement component 4 at Clinical Trials.gov Trial results on Complement component 4 Clinical Trials on Complement component 4 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Complement component 4 NICE Guidance on Complement component 4 NHS PRODIGY Guidance FDA on Complement component 4 CDC on Complement component 4
Books
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News
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Commentary
Blogs on Complement component 4
Definitions
Definitions of Complement component 4
Patient Resources / Community
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Healthcare Provider Resources
Symptoms of Complement component 4 Causes & Risk Factors for Complement component 4 Diagnostic studies for Complement component 4 Treatment of Complement component 4
Continuing Medical Education (CME)
CME Programs on Complement component 4
International
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Experimental / Informatics
List of terms related to Complement component 4

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Complement component 4 is a protein involved in the complement system.

It is cleaved into proteins 4a and 4b.

• C4a is an anaphylatoxin.
• C4b forms part of C3-convertase, in conjunction with 2a:
• C4b can bind CR1.

Clinical significance

It is responsible for the Chido Rodgers blood group system.

C4d has been identified as a biomarker for systemic lupus erythematosus.