Cefazolin
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| Image:Cefazolin.png | |
| Cefazolin
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| Systematic (IUPAC) name | |
| 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]- 8-oxo-7-([2-(tetrazol-1-yl)acetyl]amino)- 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylate | |
| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| Chemical data | |
| Formula | C14H13N8O4S3 |
| Mol. mass | 454.51 g/mol |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Metabolism | ? |
| Half life | 1.8 hours (given IV) 2 hours (given IM) |
| Excretion | Renal, unchanged |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
℞ Prescription only |
| Routes | Intravenous, intramuscular |
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Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.
The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).
Indications
Cefazolin is mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. These organisms are common on normal human skin. Resistance to cefazolin is seen in several species of bacteria.
Side effects
Side effects from cefazolin are not common. Possible side effects include:
- diarrhea
- stomach pain
- upset stomach
- vomiting
Cefazolin is marketed under the following brand names: Ancef®, Cefacidal®, Cefamezin®, Cefrina®, Elzogram®, Faxilen®, Gramaxin®, Kefazol®, Kefol®, Kefzol®, Kefzolan®, Kezolin®, Novaporin®, and Zolicef®
External links
- MedlinePlus Drug Information: Cefazolin Sodium Injection.
- Eli Lilly Cefazolin Sodium Material Safety Data Sheet.
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| Articles on Cefazolin | Most recent articles on Cefazolin • Most cited articles on Cefazolin • Review articles on Cefazolin • Articles on Cefazolin in N Eng J Med, Lancet, BMJ |
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| Evidence Based Medicine Regarding Cefazolin | Cochrane Collaboration on Cefazolin • Bandolier on Cefazolin • TRIP on Cefazolin |
| Cost Effectiveness of Cefazolin | Cost Effectiveness of Cefazolin |
| Clinical Trials Involving Cefazolin | Ongoing Trials on Cefazolin at Clinical Trials.gov • Trial results on Cefazolin • Clinical Trials on Cefazolin at Google |
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| Pharmacology Resources on Cefazolin | Dosing of Cefazolin • Drug interactions with Cefazolin • Side effects of Cefazolin • Allergic reactions to Cefazolin • Overdose information on Cefazolin • Carcinogenicity information on Cefazolin • Cefazolin in pregnancy • Pharmacokinetics of Cefazolin • |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
