Bacteroides
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Overview
| Bacteroides | ||||||||||||
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 Bacteroides spp. anaerobically cultured in blood agar medium.
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B. acidifaciens |
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Bacteroides is a genus of Gram-negative, rod-shaped bacteria. Bacteroides species are non-endospore-forming, anaerobes, and may either be motile or non-motile, depending on the species.[1] The DNA base composition is 40-48% GC. Unusual in bacterial organisms, Bacteroides membranes contain sphingolipids. They also contain meso-diaminopimelic acid in their peptidoglycan layer.
Bacteroides are normally commensal, making up the most substantial portion of the mammalian gastrointestinal flora,[2] where they play a fundamental role in processing of complex molecules to simpler ones in the host intestine. As many as 1010-1011 cells per gram of human feces have been reported.[3] They can use simple sugars when available, but the main source of energy is polysaccharides from plant sources.
Pathogenesis
Bacteroides species also benefit their host by excluding potential pathogens from colonizing the gut. Some species (B. fragilis, for example) are opportunistic human pathogens, causing infections of the peritoneal cavity, gastrointestinal surgery, and appendicitis via abscess formation, inhibiting phagocytosis, and inactivating beta-lactam antibiotics.[4] Although Bacteroides species are anaerobic, they are aerotolerant and thus can survive in the abdominal cavity.
Bacteroides are generally resistant to a wide variety of antibiotics — beta-lactams, aminoglycosides, and recently many species have acquired resistance to erythromycin and tetracycline. This high level of antibiotic resistance has prompted concerns that Bacteroides species may become a reservoir for resistance in other, more highly pathogenic bacterial strains.[5]
B. fragilis
Bacteroides fragilis is an obligate anaerobe of the gut. It is involved in 90% of anaerobic peritoneal infections. B. fragilis is generally susceptible to metronidazole, carbapenems, and beta-lactam/beta-lactamase inhibitor combinations (e.g., Unasyn, Zosyn). The bacteria has inherent high-level resistance to penicillin. Clindamycin is no longer recommended as the first-line agent for B. fragilis due to emerging high-level resistance (>30% in some reports).[6]
References
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- ↑ Madigan M, Martinko J (editors). (2005). Brock Biology of Microorganisms, 11th ed., Prentice Hall. ISBN 0-13-144329-1.
- ↑ Dorland WAN (editor) (2003). Dorland's Illustrated Medical Dictionary, 30th, W.B. Saunders. ISBN 0-7216-0146-4.
- ↑ Finegold SM, Sutter VL, Mathisen GE (1983). Normal indigenous intestinal flora (pp. 3-31) in Human intestinal microflora in health and disease.. Academic Press. ISBN 0-12-341280-3.
- ↑ Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology, 4th ed., McGraw Hill. ISBN 0-8385-8529-9.
- ↑ Salyers AA, Gupta A, Wang Y (2004). "Human intestinal bacteria as reservoirs for antibiotic resistance genes". Trends Microbiol 12 (9): 412-6. ISSN 0966-842X. PMID 15337162.
- ↑ Mandell GL, Bennett JE, Dolin R (2004). Principles and Practice of Infectious Diseases, 6th ed., Churchill Livingstone. ISBN 0443066434.
See also
External links
- Bacteroides references in Baron's Medical Microbiology (online at the NCBI bookshelf).
- Bacteriodes in detail.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
