Ankylosing spondylitis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Patients that possess the HLA-B27 variant are at the highest risk for developing ankylosing spondylitis.

Risk Factors

Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the HLA-B27 variant are at highest risk of developing the disorder. HLA-B27, demonstrated in a blood test, is occasionally used as a diagnostic, but does not distinguish AS from other diseases and is therefore not of real diagnostic value. Over 95% of people with AS are HLA-B27 positive, although this ratio varies from population to population (only 50% of African American patients with AS possess HLA-B27, and it is close to 80% among AS patients from Mediterranean countries).

Researches demonstrate the following factors may be associated with this disease.

  • Recent data demonstrate gene ARTS1 and IL23R are associated with ankylosing spondylitis.
  • Gender: Male
  • Age: 10~40 years old.

References


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