Adult bronchiolitis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Other diagnostic studies for adult bronchiolitis include lung biopsy, which rules out other causes of dyspnea and can confirm bronchiolitis obliterans syndrome, and histopathology, which demonstrates abnormalities in the walls of membranous or respiratory bronchioles, tubular narrowing or total obliteration of the lumen, concentric T lymphocyte infiltration, smooth muscle hypertrophy in the small airways, bronchiolectasia with mucus plugging, and fibrosis and scarring.

Other Diagnostic Studies

  • Other diagnostic studies for adult bronchiolitis include:[1][2][3]
    • Lung biopsy, which is particularly helpful in ruling out other causes of dyspnea and can confirm bronchiolitis obliterans syndrome.
    • Histopathology, which demonstrates:
      • Abnormalities in the walls of membranous or respiratory bronchioles
      • Tubular narrowing or total obliteration of the lumen
      • Concentric T lymphocyte infiltration
      • Smooth muscle hypertrophy in the small airways
      • Bronchiolectasia with mucus plugging
      • Fibrosis
      • Scarring
Source:commons.wikimedia.org, shows a terminal bronchiole completely occupied by macrophages and tobacco pigments. By Yale Rosen from USA - Respiratory bronchiolitisUploaded by CFCF, CC BY-SA 2.0, https://commons.wikimedia.org/w/index.php?curid=31127983


References

  1. Couture C, Colby TV (October 2003). "Histopathology of bronchiolar disorders". Semin Respir Crit Care Med. 24 (5): 489–98. doi:10.1055/s-2004-815600. PMID 16088569.
  2. Myong NH, Shin DH, Lee KY (April 2001). "A clinicopathologic study on three cases of constrictive bronchiolitis". J. Korean Med. Sci. 16 (2): 150–4. doi:10.3346/jkms.2001.16.2.150. PMC 3054720. PMID 11306739.
  3. Chamberlain D, Maurer J, Chaparro C, Idolor L (1994). "Evaluation of transbronchial lung biopsy specimens in the diagnosis of bronchiolitis obliterans after lung transplantation". J. Heart Lung Transplant. 13 (6): 963–71. PMID 7865530.

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