Acute promyelocytic leukemia history and symptoms

Jump to: navigation, search

Acute promyelocytic leukemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Acute promyelocytic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Other Imaging Studies

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary PreventionSurgery

Secondary PreventionSurgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Acute promyelocytic leukemia history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Acute promyelocytic leukemia history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Acute promyelocytic leukemia history and symptoms

CDC on Acute promyelocytic leukemia history and symptoms

Acute promyelocytic leukemia history and symptoms in the news

Blogs on Acute promyelocytic leukemia history and symptoms

Directions to Hospitals Treating Acute promyelocytic leukemia

Risk calculators and risk factors for Acute promyelocytic leukemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2], Sogand Goudarzi, MD; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

Signs and symptoms of acute promyelocytic leukemia are similar to other forms of leukemia, but bleeding and hemorrhagic events are more specific for acute promyelocytic leukemia since these patients are more likely to present with disseminated intravascular coagulation (coagulopathy).

Symptoms

Patients with acute promyelocytic leukemia present with a variety of symptoms. The symptoms are related to decreased production of normal red blood cells, white blood cells, and platelets.[1]

Patients with acute promyelocytic leukemia have an excess number of blasts in the bone marrow, and this results in myelophthisis, or crowding out of the normal hematopoietic cells, which accounts for the symptoms.[2][3]

References

  1. Hu R, Wu Y, Jiang X, Zhang W, Xu L (2011). "Clinical symptoms and chemotherapy completion in elderly patients with newly diagnosed acute leukemia: a retrospective comparison study with a younger cohort". BMC Cancer. 11: 224. doi:10.1186/1471-2407-11-224. PMC 3130702. PMID 21645417.
  2. Efficace, Fabio; Breccia, Massimo; Avvisati, Giuseppe; Cottone, Francesco; Intermesoli, Tamara; Borlenghi, Erika; Carluccio, Paola; Rodeghiero, Francesco; Fabbiano, Francesco; Luppi, Mario; Romani, Claudio; Sborgia, Marco; D’Ardia, Stefano; Nobile, Francesco; Cantore, Nicola; Crugnola, Monica; Nadali, Gianpaolo; Vignetti, Marco; Amadori, Sergio; Lo Coco, Francesco (2018). "Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia". Leukemia. doi:10.1038/s41375-018-0325-4. ISSN 0887-6924.
  3. Nebgen DR, Rhodes HE, Hartman C, Munsell MF, Lu KH (August 2016). "Abnormal Uterine Bleeding as the Presenting Symptom of Hematologic Cancer". Obstet Gynecol. 128 (2): 357–63. doi:10.1097/AOG.0000000000001529. PMC 4961605. PMID 27400009.

Linked-in.jpg