Acute promyelocytic leukemia other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]

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Overview

Other diagnostic studies

  • Lumber puncture: Assessment of the cerebrospinal fluid (CSF) can be done via lumbar puncture. This diagnostic study is especially useful for patients with acute promyelocytic leukemia who have neurologic deficits. The cell count from the cerebrospinal fluid will show malignant myeloid cells (typically greater than 2 cells per microliter of cerebrospinal fluid). Treatment of cerebrospinal fluid involvement includes methotrexate, hydrocortisone, and cytarabine.[1]

References

  1. Montesinos P, Díaz-Mediavilla J, Debén G, Prates V, Tormo M, Rubio V; et al. (2009). "Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy without intrathecal prophylaxis.". Haematologica. 94 (9): 1242–9. PMC 2738716Freely accessible. PMID 19608685. doi:10.3324/haematol.2009.007872. 

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