Acinic cell carcinoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Swathi Venkatesan, M.B.B.S.[2]

  • Godwin et al. first referred Acinic Cell Carcinoma almost 50 years prior. [1]
  • The “acinar” term is derived from Latin term “acinus”, which means a cluster of and looks like grapes branch.
  • The histological appearance is quite similar to secretory parenchymatous cells. [2]
  • Before discovering this disease, clinically Acinic Cell Carcinoma was unrecognized.
  • At the time after recognizing the disease, it thought to be the nature of the tumor is benign.
  • Afterward, it has been detected that the recurrence tendency of the tumor showed the possibility of the malignant nature of the tumor.
  • Later WHO (World Health Organization) re-classified as a “malignant carcinoma” with low-grade behavior (2, 3).

References

  1. Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS (2009). "Acinic cell carcinoma of the salivary glands: a literature review". Hematol Oncol Stem Cell Ther. 2 (1): 259–64. PMID 20063555.
  2. "Acinic cell carcinoma of the salivary glands: A literature review - ScienceDirect".

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