Acinic cell carcinoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

There is very little approved information about acinic cell carcinoma risk factors but Familial predisposition Previous radiation exposure may play an important role.

Risk Factors

Common risk factors in the development of acinic cell carcinoma include:

Common Risk Factors

  • Common risk factors in the development of acinic cell carcinoma may be occupational, environmental, genetic[1][2][3].
  • Common risk factors in the development of acinic cell carcinoma include:
    • Familial predisposition
    • Previous radiation exposure
    • Cowden syndrome
    • Acinic breast cancer may develop in a BRCA1 mutation carrier
    • There were no cases among long-term atomic bomb survivors

References

  1. Saku T, Hayashi Y, Takahara O, Matsuura H, Tokunaga M, Tokunaga M; et al. (1997). "Salivary gland tumors among atomic bomb survivors, 1950-1987". Cancer. 79 (8): 1465–75. PMID 9118025.
  2. Depowski PL, Setzen G, Chui A, Koltai PJ, Dollar J, Ross JS (1999). "Familial occurrence of acinic cell carcinoma of the parotid gland". Arch Pathol Lab Med. 123 (11): 1118–20. doi:10.1043/0003-9985(1999)123<1118:FOOACC>2.0.CO;2. PMID 10539921.
  3. Villeneuve, Hugo; Tremblay, Steve; Galiatsatos, Polymnia; Hamel, Nancy; Guertin, Louis; Morency, Renald; Tischkowitz, Marc (2011). "Acinic cell carcinoma of the retromolar trigone region: expanding the tumor phenotype in Cowden syndrome?". Familial Cancer. 10 (4): 691–694. doi:10.1007/s10689-011-9472-8. ISSN 1389-9600.

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