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==Overview==
==Overview==
 
Vertigo is identified as 'room spinning around'. It is a type of [[dizziness]]. [[Presyncope]], [[lightheadedness]] and [[disequilibrium]] are other types of [[dizziness]] and should be ruled out. The cause of vertigo can be peripheral or central in origin. In peripheral vertigo, [[dysfunction]] is in the vestibular system
which includes the [[vestibule]] ([[utricle]] and [[saccule]]), [[semicircular canals]], and the [[vestibular nerve]]. Central [[etiologies]] of vertigo usually originates from the [[brainstem]] or [[cerebellum]]. Most common causes of vertigo to appear in primary-care are [[benign paroxysmal positional vertigo]], [[acute]] [[vestibular neuronitis]], and [[Ménière’s disease]]. Best approach to diagnose vertigo etiology is to obtain a complete history paired with a focal examination including assessment of [[cranial nerves]], [[nystagmus]], [[sensorineural hearing loss]] (Rinne or Webers test), [[otoscopic]] exam of ear canal and [[tympanic membrane]], HINTS (cover/uncover test), [[Dix-Hallpike maneuver]] and/or Hennebert’s sign. [[Acute]]/severe attacks of vertigo may subside in a day or two after brainstem compensation. Supportive therapy includes bed rest, [[antihistamine]], [[antiemetic]] ([[prochlorperazine]], [[metoclopramide]]) to relief the [[symptom]]. These drugs should not be used for a long period of time as it may delay the compensatory mechanism in the [[brainstem]] and result in the prolongation of vertigo [[symptom]].Treating the underlying cause is the definitive [[treatment]] of vertigo.


==Historical Perspective==
==Historical Perspective==
*Vertigo is derived from the [[Latin]] words ''vertigin'' and ''vertere'' which means  "a whirling or spinning movement," and "to turn", respectively.<ref>{{cite web|url=http://www.m-w.com/dictionary/vertigo |title=Definition of vertigo - Merriam-Webster Online Dictionary |accessdate=2007-09-19 |format=|work=}}</ref>
Vertigo is derived from the [[Latin]] words ''vertigin'' and ''vertere'' which means  "a whirling or spinning movement," and "to turn", respectively.


==Classification==
==Classification==
*Vertigo is classified on the basis of the location of dysfunction into:
Vertigo is typically classified into one of two categories depending on the location of the damaged vestibular pathway. These are peripheral or central vertigo. Each category has a distinct set of characteristics and associated findings. Vertigo can also occur after long flights or boat journeys where the mind gets used to turbulence, resulting in a person feeling as if they are moving up and down. This usually subsides after a few days.
**Peripheral: Lesion in the inner ear or [[vestibulocochlear nerve]].
 
**Central: Lesion in [[brainstem]] or [[cerebellum]].  
==Pathophysiology==
*It can also be classified on the basis of its time course or duration:
Disruption in the [[vestibular system]] results in vertigo. The region of disruption could be peripheral ([[labyrinth]], [[vestibular]] [[nerve]]) or central ([[brainstem]], [[cerebellum]]). [[Vestibulo-ocular reflex]] is responsible for stabilizing [[gaze]] during head movement, it is controlled by six [[neurotransmitters]], which are [[glutamate]], [[acetylcholine]], [[GABA]], [[dopamine]], [[histamine]] and [[norepinephrine]].
**Lasting a day or longer
**Lasting minutes to hours
**Lasting seconds


==Causes==
==Causes==
*Common causes of vertigo:
Common causes of vertigo are [[Ménière’s disease]], [[benign paroxysmal positional vertigo]], [[labyrinthitis]], [[vestibular neuritis]]. Life-threatening causes include [[brainstem]] [[ischemia]]/[[hemorrhage]], [[hypertension]] [[crisis]], [[drug]] [[overdose]], [[cyanide]] [[poisoning]].
**Peripheral: [[Benign paroxysmal positional vertigo]] (BPPV), [[Ménière's disease]], [[acute labyrinthitis]], [[vestibular neuritis]], [[Herpes zoster oticus]]([[Ramsay Hunt syndrome]]).
**Central: Ischemic/hemorrhagic [[stroke]] in the [[cerebellum]] or [[brainstem]], tumor in [[cerebellopontine]] angle, vestibular [[migraine]].
**Drug induced
**Psychological Vertigo


==Differentiating Vertigo from other Diseases==
==Differentiating Vertigo from other Diseases==
*Vertigo is a type of dizziness therefore it must be differentiated from other diseases that cause imbalance, [[dizziness]], and [[lightheadedness]].
Vertigo is one of the four type of [[dizziness]], therefore it must be differentiated from other forms of [[dizziness]], [[presyncope]], [[lightheadedness]] and [[disequilibrium]].


==Epidemiology and Demographics==
==Epidemiology and Demographics==
*Among the patient who presents with [[dizziness]] in the primary care setting, fifty-four percent have vertigo upon investigation.
Among the patient who presents with [[dizziness]] in the primary care setting, fifty-four percent have vertigo upon investigation. [[Benign paroxysmal positional vertigo]], [[acute vestibular neuronitis]], and [[Ménière’s disease]] account for ninety-three percent of patients diagnosed with true vertigo in a primary care setting.


==Risk Factors==
==Risk Factors==
*There are no established risk factors for vertigo, as it is a symptom of an underlying disease.
There are no established risk factors for vertigo, as it is a symptom of an underlying disease. However, vertigo can be prevented in some cases by controlling risk factors for the underlying cause.
*However, vertigo can be prevented in some cases by controlling risk factors for the underlying cause.


==Screening==
==Screening==
*There is insufficient evidence to recommend routine [[screening]] for vertigo.
There is insufficient evidence to recommend routine [[screening]] for vertigo.
 
==Diagnostic Study of Choice==
There are no established criteria for the diagnosis of vertigo. The best approach to diagnose vertigo [[etiology]] is to obtain a complete history paired with a focal examination.
 
==History and Symptoms==
It is important to differentiate between other causes of [[dizziness]] before evaluating the cause of vertigo. True vertigo is described as the room spinning around the patient. Once true vertigo is established next step is to identify if the origin of [[dysfunction]] is central or peripheral. Detailed investigation of the time course of vertigo and associated signs and [[symptoms]] aid in identifying the cause of vertigo.
 
==Physical Examination==
Physical examination of patients experiencing vertigo should include assessment of cranial nerves, nystagmus, sensorineural hearing loss (Rinne or Webers test), otoscopic exam of the ear canal and tympanic membrane, HINTS (cover/uncover test), Dix-Hallpike maneuver, and/or Hennebert’s sign.
 
==Laboratory Findings==
There are no diagnostic laboratory findings associated with vertigo.


==Diagnosis==
==Electrocardiogram==
'''Diagnostic Study of Choice'''
There are no [[ECG]] findings associated with vertigo. However, an [[ECG]] should be ordered to look for cardiac causes of [[dizziness]] including [[bradycardia]], [[orthostatic hypotension]] resulting in poor [[circulation]], privided true vertigo is not established as the cause od [[dizziness]] in the [[patient]]
*There are no established criteria for the diagnosis of vertigo. Associated signs and symptoms should be identified to reach the underlying cause of vertigo.


'''History and Symptoms'''
==X-ray==
*It is important to differentiate between other causes of dizziness before evaluating for the cause of vertigo. True vertigo is described as the room spinning around the patient.
An [[x-ray]] of the [[cervical]] [[spine]] may be helpful in the diagnosis of peripheral vertigo of unknown origin. Findings on an x-ray include, extended [[cervical]] [[spine]] posture, [[degenerative]] changes in the [[cervical]] [[spine]] can cause peripheral vertigo, and/or uncovertebral arthroses.
*Once true vertigo is established next step is to identify if the origin of dysfunction is central or peripheral.  


'''Physical Examination'''
==Echocardiography or Ultrasound==
*
There are no [[echocardiography]]/[[ultrasound]] findings associated with vertigo. However, an [[echocardiography]]/[[ultrasound]] may be helpful in the [[diagnosis]] of underlying [[etiology]] of vertigo or to rule out [[cardiac]] cause of [[dizziness]] if true vertigo is not established. Use of echo-color [[Doppler]] [[ultrasound]] is helpful to look for [[plaque]] in [[extracranial]] vessels supplying [[blood]] to [[brain]] in [[patients]] with peripheral vertigo but exact cause still unidentified.


'''Laboratory Findings'''
==CT scan==
*There are no diagnostic laboratory findings associated with vertigo.
[[CT scan]] is not the first-line [[imaging]] method preferred to determine the underlying cause of central vertigo due to its low [[sensitivity]] in identifying [[ischemic]] [[stroke]] and a negative [[CT scan]] cannot completely rule out the central cause of vertigo, it still needs to be further investigated with the help of an [[MRI]].
*


'''Electrocardiogram'''
==MRI==
*There are no ECG findings associated with vertigo.
An [[MRI]] is the first-line imaging if the cause of vertigo is suspected to be central in origin. [[MRI]] is superior to a [[CT]] scan due to its ability to visualize the [[posterior fossa]].
*ECG monitoring may be indicated if the cause of dizziness is uncertain.


'''X-ray'''
==Other Imaging Findings==
*There are no [[x-ray]] findings associated with vertigo.
There are no other [[imaging]] findings associated with vertigo. However, some underlying cause may benefit from [[electronystagmography]] or [[electroencephalogram]]. Further [[imaging]] should be conducted according to the diagnostic requirements of the [[etiology]] behind the [[symptom]] of vertigo.


'''Echocardiography or Ultrasound'''
==Other Diagnostic Studies==
*There are no [[echocardiography]]/[[ultrasound]] findings associated with vertigo.
There are no other [[Diagnosis|diagnostic studies]] associated with vertigo. However, the causes of vertigo should be evaluated further according to its [[diagnostic]] [[protocol]].


'''CT scan'''
==Medical Therapy==
*[[CT]] scan is not the first-line imaging preferred to determine the underlying cause of central vertigo.
[[Acute]]/severe attacks of vertigo may subside in a day or two after brainstem compensation. Supportive therapy includes bed rest, [[antihistamine]], [[antiemetic]] ([[prochlorperazine]], [[metoclopramide]]) to relief the [[symptom]]. [[Antihistamine]] ([[meclizine]],[[betahistine]],[[dimenhydrinate]]), [[antiemetic]], [[anticholinergic]] ([[scopolamine]]) and [[benzodiazepines]] ([[diazepam]],[[lorazepam]]) are the common medications used to treat vertigo as a [[symptom]]. These drugs should not be used for a long period of time as it may delay the compensatory mechanism in the [[brainstem]] and result in the prolongation of vertigo [[symptom]]. Some patients may be a candidate for [[vestibular]] [[rehabilitation]]. Treating the underlying cause is the definitive treatment of vertigo.


'''MRI'''
==Surgery==
*An [[MRI]] is the first-line imaging if the cause of vertigo is suspected to be central in origin.
For the majority of underlying causes of vertigo, the mainstay of treatment is medical therapy. Surgery is usually reserved for patients with either [[tumor]]-associated vertigo, [[cholesteatoma]], and/or when it does not respond to multiple medical therapies.


'''Other Imaging Findings'''
==Primary Prevention==
There are no established measures for the [[primary prevention]] of vertigo, as it occurs as a [[symptom]] of underlying [[pathology]]. In some diseases controlling risk factors or triggering, factors can prevent the disease hence preventing the symptoms.


'''Other Diagnostic Studies'''
==Secondary Prevention==
Effective measures for the [[secondary prevention]] of vertigo include optimal treatment of the underlying [[etiology]].


==References==
==References==
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[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Otolaryngology]]
[[Category:Otolaryngology]]
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Latest revision as of 20:10, 22 January 2021

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Overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zehra Malik, M.B.B.S[2]

Overview

Vertigo is identified as 'room spinning around'. It is a type of dizziness. Presyncope, lightheadedness and disequilibrium are other types of dizziness and should be ruled out. The cause of vertigo can be peripheral or central in origin. In peripheral vertigo, dysfunction is in the vestibular system which includes the vestibule (utricle and saccule), semicircular canals, and the vestibular nerve. Central etiologies of vertigo usually originates from the brainstem or cerebellum. Most common causes of vertigo to appear in primary-care are benign paroxysmal positional vertigo, acute vestibular neuronitis, and Ménière’s disease. Best approach to diagnose vertigo etiology is to obtain a complete history paired with a focal examination including assessment of cranial nerves, nystagmus, sensorineural hearing loss (Rinne or Webers test), otoscopic exam of ear canal and tympanic membrane, HINTS (cover/uncover test), Dix-Hallpike maneuver and/or Hennebert’s sign. Acute/severe attacks of vertigo may subside in a day or two after brainstem compensation. Supportive therapy includes bed rest, antihistamine, antiemetic (prochlorperazine, metoclopramide) to relief the symptom. These drugs should not be used for a long period of time as it may delay the compensatory mechanism in the brainstem and result in the prolongation of vertigo symptom.Treating the underlying cause is the definitive treatment of vertigo.

Historical Perspective

Vertigo is derived from the Latin words vertigin and vertere which means "a whirling or spinning movement," and "to turn", respectively.

Classification

Vertigo is typically classified into one of two categories depending on the location of the damaged vestibular pathway. These are peripheral or central vertigo. Each category has a distinct set of characteristics and associated findings. Vertigo can also occur after long flights or boat journeys where the mind gets used to turbulence, resulting in a person feeling as if they are moving up and down. This usually subsides after a few days.

Pathophysiology

Disruption in the vestibular system results in vertigo. The region of disruption could be peripheral (labyrinth, vestibular nerve) or central (brainstem, cerebellum). Vestibulo-ocular reflex is responsible for stabilizing gaze during head movement, it is controlled by six neurotransmitters, which are glutamate, acetylcholine, GABA, dopamine, histamine and norepinephrine.

Causes

Common causes of vertigo are Ménière’s disease, benign paroxysmal positional vertigo, labyrinthitis, vestibular neuritis. Life-threatening causes include brainstem ischemia/hemorrhage, hypertension crisis, drug overdose, cyanide poisoning.

Differentiating Vertigo from other Diseases

Vertigo is one of the four type of dizziness, therefore it must be differentiated from other forms of dizziness, presyncope, lightheadedness and disequilibrium.

Epidemiology and Demographics

Among the patient who presents with dizziness in the primary care setting, fifty-four percent have vertigo upon investigation. Benign paroxysmal positional vertigo, acute vestibular neuronitis, and Ménière’s disease account for ninety-three percent of patients diagnosed with true vertigo in a primary care setting.

Risk Factors

There are no established risk factors for vertigo, as it is a symptom of an underlying disease. However, vertigo can be prevented in some cases by controlling risk factors for the underlying cause.

Screening

There is insufficient evidence to recommend routine screening for vertigo.

Diagnostic Study of Choice

There are no established criteria for the diagnosis of vertigo. The best approach to diagnose vertigo etiology is to obtain a complete history paired with a focal examination.

History and Symptoms

It is important to differentiate between other causes of dizziness before evaluating the cause of vertigo. True vertigo is described as the room spinning around the patient. Once true vertigo is established next step is to identify if the origin of dysfunction is central or peripheral. Detailed investigation of the time course of vertigo and associated signs and symptoms aid in identifying the cause of vertigo.

Physical Examination

Physical examination of patients experiencing vertigo should include assessment of cranial nerves, nystagmus, sensorineural hearing loss (Rinne or Webers test), otoscopic exam of the ear canal and tympanic membrane, HINTS (cover/uncover test), Dix-Hallpike maneuver, and/or Hennebert’s sign.

Laboratory Findings

There are no diagnostic laboratory findings associated with vertigo.

Electrocardiogram

There are no ECG findings associated with vertigo. However, an ECG should be ordered to look for cardiac causes of dizziness including bradycardia, orthostatic hypotension resulting in poor circulation, privided true vertigo is not established as the cause od dizziness in the patient

X-ray

An x-ray of the cervical spine may be helpful in the diagnosis of peripheral vertigo of unknown origin. Findings on an x-ray include, extended cervical spine posture, degenerative changes in the cervical spine can cause peripheral vertigo, and/or uncovertebral arthroses.

Echocardiography or Ultrasound

There are no echocardiography/ultrasound findings associated with vertigo. However, an echocardiography/ultrasound may be helpful in the diagnosis of underlying etiology of vertigo or to rule out cardiac cause of dizziness if true vertigo is not established. Use of echo-color Doppler ultrasound is helpful to look for plaque in extracranial vessels supplying blood to brain in patients with peripheral vertigo but exact cause still unidentified.

CT scan

CT scan is not the first-line imaging method preferred to determine the underlying cause of central vertigo due to its low sensitivity in identifying ischemic stroke and a negative CT scan cannot completely rule out the central cause of vertigo, it still needs to be further investigated with the help of an MRI.

MRI

An MRI is the first-line imaging if the cause of vertigo is suspected to be central in origin. MRI is superior to a CT scan due to its ability to visualize the posterior fossa.

Other Imaging Findings

There are no other imaging findings associated with vertigo. However, some underlying cause may benefit from electronystagmography or electroencephalogram. Further imaging should be conducted according to the diagnostic requirements of the etiology behind the symptom of vertigo.

Other Diagnostic Studies

There are no other diagnostic studies associated with vertigo. However, the causes of vertigo should be evaluated further according to its diagnostic protocol.

Medical Therapy

Acute/severe attacks of vertigo may subside in a day or two after brainstem compensation. Supportive therapy includes bed rest, antihistamine, antiemetic (prochlorperazine, metoclopramide) to relief the symptom. Antihistamine (meclizine,betahistine,dimenhydrinate), antiemetic, anticholinergic (scopolamine) and benzodiazepines (diazepam,lorazepam) are the common medications used to treat vertigo as a symptom. These drugs should not be used for a long period of time as it may delay the compensatory mechanism in the brainstem and result in the prolongation of vertigo symptom. Some patients may be a candidate for vestibular rehabilitation. Treating the underlying cause is the definitive treatment of vertigo.

Surgery

For the majority of underlying causes of vertigo, the mainstay of treatment is medical therapy. Surgery is usually reserved for patients with either tumor-associated vertigo, cholesteatoma, and/or when it does not respond to multiple medical therapies.

Primary Prevention

There are no established measures for the primary prevention of vertigo, as it occurs as a symptom of underlying pathology. In some diseases controlling risk factors or triggering, factors can prevent the disease hence preventing the symptoms.

Secondary Prevention

Effective measures for the secondary prevention of vertigo include optimal treatment of the underlying etiology.

References