Vaginal cancer epidemiology and demographics: Difference between revisions
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{{CMG}} {{ | {{CMG}} {{AE}} {{sali}} | ||
{{Vaginal cancer}} | {{Vaginal cancer}} | ||
==Overview== | ==Overview== | ||
In 2015, the incidence of vaginal cancer is approximately 2-3 per 100,000 individuals with a death number of 910. | In 2015, the incidence of [[vaginal cancer]] is approximately 2-3 per 100,000 individuals with a death number of 910. | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
* Carcinomas of the vagina are uncommon tumors comprising about 1% of the cancers that arise in the female genital system<ref name="pmid25476235">{{cite journal |vauthors=Gadducci A, Fabrini MG, Lanfredini N, Sergiampietri C |title=Squamous cell carcinoma of the vagina: natural history, treatment modalities and prognostic factors |journal=Crit. Rev. Oncol. Hematol. |volume=93 |issue=3 |pages=211–24 |date=March 2015 |pmid=25476235 |doi=10.1016/j.critrevonc.2014.09.002 |url=}}</ref>. | * [[Carcinomas]] of the [[vagina]] are uncommon tumors comprising about 1% of the [[cancers]] that arise in the [[female genital system]]<ref name="pmid25476235">{{cite journal |vauthors=Gadducci A, Fabrini MG, Lanfredini N, Sergiampietri C |title=Squamous cell carcinoma of the vagina: natural history, treatment modalities and prognostic factors |journal=Crit. Rev. Oncol. Hematol. |volume=93 |issue=3 |pages=211–24 |date=March 2015 |pmid=25476235 |doi=10.1016/j.critrevonc.2014.09.002 |url=}}</ref>. | ||
* Estimated new cases and deaths from vaginal (and other female genital) cancer in the United States in 2015<ref name="pmid25559415">{{cite journal |vauthors=Siegel RL, Miller KD, Jemal A |title=Cancer statistics, 2015 |journal=CA Cancer J Clin |volume=65 |issue=1 |pages=5–29 |date=2015 |pmid=25559415 |doi=10.3322/caac.21254 |url=}}</ref>: | * Estimated new cases and deaths from vaginal (and other female genital) cancer in the United States in 2015<ref name="pmid25559415">{{cite journal |vauthors=Siegel RL, Miller KD, Jemal A |title=Cancer statistics, 2015 |journal=CA Cancer J Clin |volume=65 |issue=1 |pages=5–29 |date=2015 |pmid=25559415 |doi=10.3322/caac.21254 |url=}}</ref>: | ||
:* New cases: 4,070. | :* New cases: 4,070. | ||
:* Deaths: 910. | :* Deaths: 910. | ||
* Estimated new cases and deaths from vaginal (and other female genital) cancer in the United States in 2008: | * Estimated new cases and deaths from [[vaginal]] (and other [[female]] [[genital]]) [[cancer]] in the United States in 2008: | ||
:* New cases: 2,210. | :* New cases: 2,210. | ||
:* Deaths: 760. | :* Deaths: 760. | ||
*1 in 100,000 women will be diagnosed with in situ or invasive vaginal cancer<ref name="pmid19384118">{{cite journal |vauthors=Shah CA, Goff BA, Lowe K, Peters WA, Li CI |title=Factors affecting risk of mortality in women with vaginal cancer |journal=Obstet Gynecol |volume=113 |issue=5 |pages=1038–45 |date=May 2009 |pmid=19384118 |pmc=2746762 |doi=10.1097/AOG.0b013e31819fe844 |url=}}</ref>. | *1 in 100,000 women will be diagnosed with in situ or invasive [[vaginal cancer]]<ref name="pmid19384118">{{cite journal |vauthors=Shah CA, Goff BA, Lowe K, Peters WA, Li CI |title=Factors affecting risk of mortality in women with vaginal cancer |journal=Obstet Gynecol |volume=113 |issue=5 |pages=1038–45 |date=May 2009 |pmid=19384118 |pmc=2746762 |doi=10.1097/AOG.0b013e31819fe844 |url=}}</ref>. | ||
*Most cases of vaginal cancer are likely mediated by human papillomavirus (HPV) infection, as with cervical cancer<ref name="pmid25155250">{{cite journal |vauthors=Alemany L, Saunier M, Tinoco L, Quirós B, Alvarado-Cabrero I, Alejo M, Joura EA, Maldonado P, Klaustermeier J, Salmerón J, Bergeron C, Petry KU, Guimerà N, Clavero O, Murillo R, Clavel C, Wain V, Geraets DT, Jach R, Cross P, Carrilho C, Molina C, Shin HR, Mandys V, Nowakowski AM, Vidal A, Lombardi L, Kitchener H, Sica AR, Magaña-León C, Pawlita M, Quint W, Bravo IG, Muñoz N, de Sanjosé S, Bosch FX |title=Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples |journal=Eur. J. Cancer |volume=50 |issue=16 |pages=2846–54 |date=November 2014 |pmid=25155250 |doi=10.1016/j.ejca.2014.07.018 |url=}}</ref>. | *Most cases of [[vaginal cancer]] are likely mediated by [[human papillomavirus]] ([[HPV]]) [[infection]], as with [[cervical cancer]]<ref name="pmid25155250">{{cite journal |vauthors=Alemany L, Saunier M, Tinoco L, Quirós B, Alvarado-Cabrero I, Alejo M, Joura EA, Maldonado P, Klaustermeier J, Salmerón J, Bergeron C, Petry KU, Guimerà N, Clavero O, Murillo R, Clavel C, Wain V, Geraets DT, Jach R, Cross P, Carrilho C, Molina C, Shin HR, Mandys V, Nowakowski AM, Vidal A, Lombardi L, Kitchener H, Sica AR, Magaña-León C, Pawlita M, Quint W, Bravo IG, Muñoz N, de Sanjosé S, Bosch FX |title=Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples |journal=Eur. J. Cancer |volume=50 |issue=16 |pages=2846–54 |date=November 2014 |pmid=25155250 |doi=10.1016/j.ejca.2014.07.018 |url=}}</ref>. | ||
*Vaginal cancer has the same risk factors as cervical neoplasia: multiple lifetime sexual partners, early age at first intercourse, and being a current smoker<ref name="pmid11812085">{{cite journal |vauthors=Daling JR, Madeleine MM, Schwartz SM, Shera KA, Carter JJ, McKnight B, Porter PL, Galloway DA, McDougall JK, Tamimi H |title=A population-based study of squamous cell vaginal cancer: HPV and cofactors |journal=Gynecol. Oncol. |volume=84 |issue=2 |pages=263–70 |date=February 2002 |pmid=11812085 |doi=10.1006/gyno.2001.6502 |url=}}</ref>. | *Vaginal cancer has the same risk factors as [[cervical]] [[neoplasia]]: multiple lifetime [[sexual]] partners, early age at first [[intercourse]], and being a current smoker<ref name="pmid11812085">{{cite journal |vauthors=Daling JR, Madeleine MM, Schwartz SM, Shera KA, Carter JJ, McKnight B, Porter PL, Galloway DA, McDougall JK, Tamimi H |title=A population-based study of squamous cell vaginal cancer: HPV and cofactors |journal=Gynecol. Oncol. |volume=84 |issue=2 |pages=263–70 |date=February 2002 |pmid=11812085 |doi=10.1006/gyno.2001.6502 |url=}}</ref>. | ||
*There is evidence that some high-grade vulvar and vaginal intraepithelial neoplasia are monoclonal lesions derived from high-grade or malignant cervical disease<ref name="pmid16368943">{{cite journal |vauthors=Vinokurova S, Wentzensen N, Einenkel J, Klaes R, Ziegert C, Melsheimer P, Sartor H, Horn LC, Höckel M, von Knebel Doeberitz M |title=Clonal history of papillomavirus-induced dysplasia in the female lower genital tract |journal=J. Natl. Cancer Inst. |volume=97 |issue=24 |pages=1816–21 |date=December 2005 |pmid=16368943 |doi=10.1093/jnci/dji428 |url=}}</ref>. | *There is evidence that some high-grade [[vulvar]] and [[vaginal intraepithelial neoplasia]] are [[monoclonal]] lesions derived from high-grade or [[malignant]] [[cervical]] disease<ref name="pmid16368943">{{cite journal |vauthors=Vinokurova S, Wentzensen N, Einenkel J, Klaes R, Ziegert C, Melsheimer P, Sartor H, Horn LC, Höckel M, von Knebel Doeberitz M |title=Clonal history of papillomavirus-induced dysplasia in the female lower genital tract |journal=J. Natl. Cancer Inst. |volume=97 |issue=24 |pages=1816–21 |date=December 2005 |pmid=16368943 |doi=10.1093/jnci/dji428 |url=}}</ref>. | ||
==References== | ==References== | ||
Latest revision as of 12:25, 6 February 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Syed Musadiq Ali M.B.B.S.[2]
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Overview
In 2015, the incidence of vaginal cancer is approximately 2-3 per 100,000 individuals with a death number of 910.
Epidemiology and Demographics
- Carcinomas of the vagina are uncommon tumors comprising about 1% of the cancers that arise in the female genital system[1].
- Estimated new cases and deaths from vaginal (and other female genital) cancer in the United States in 2015[2]:
- New cases: 4,070.
- Deaths: 910.
- Estimated new cases and deaths from vaginal (and other female genital) cancer in the United States in 2008:
- New cases: 2,210.
- Deaths: 760.
- 1 in 100,000 women will be diagnosed with in situ or invasive vaginal cancer[3].
- Most cases of vaginal cancer are likely mediated by human papillomavirus (HPV) infection, as with cervical cancer[4].
- Vaginal cancer has the same risk factors as cervical neoplasia: multiple lifetime sexual partners, early age at first intercourse, and being a current smoker[5].
- There is evidence that some high-grade vulvar and vaginal intraepithelial neoplasia are monoclonal lesions derived from high-grade or malignant cervical disease[6].
References
- ↑ Gadducci A, Fabrini MG, Lanfredini N, Sergiampietri C (March 2015). "Squamous cell carcinoma of the vagina: natural history, treatment modalities and prognostic factors". Crit. Rev. Oncol. Hematol. 93 (3): 211–24. doi:10.1016/j.critrevonc.2014.09.002. PMID 25476235.
- ↑ Siegel RL, Miller KD, Jemal A (2015). "Cancer statistics, 2015". CA Cancer J Clin. 65 (1): 5–29. doi:10.3322/caac.21254. PMID 25559415.
- ↑ Shah CA, Goff BA, Lowe K, Peters WA, Li CI (May 2009). "Factors affecting risk of mortality in women with vaginal cancer". Obstet Gynecol. 113 (5): 1038–45. doi:10.1097/AOG.0b013e31819fe844. PMC 2746762. PMID 19384118.
- ↑ Alemany L, Saunier M, Tinoco L, Quirós B, Alvarado-Cabrero I, Alejo M, Joura EA, Maldonado P, Klaustermeier J, Salmerón J, Bergeron C, Petry KU, Guimerà N, Clavero O, Murillo R, Clavel C, Wain V, Geraets DT, Jach R, Cross P, Carrilho C, Molina C, Shin HR, Mandys V, Nowakowski AM, Vidal A, Lombardi L, Kitchener H, Sica AR, Magaña-León C, Pawlita M, Quint W, Bravo IG, Muñoz N, de Sanjosé S, Bosch FX (November 2014). "Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples". Eur. J. Cancer. 50 (16): 2846–54. doi:10.1016/j.ejca.2014.07.018. PMID 25155250.
- ↑ Daling JR, Madeleine MM, Schwartz SM, Shera KA, Carter JJ, McKnight B, Porter PL, Galloway DA, McDougall JK, Tamimi H (February 2002). "A population-based study of squamous cell vaginal cancer: HPV and cofactors". Gynecol. Oncol. 84 (2): 263–70. doi:10.1006/gyno.2001.6502. PMID 11812085.
- ↑ Vinokurova S, Wentzensen N, Einenkel J, Klaes R, Ziegert C, Melsheimer P, Sartor H, Horn LC, Höckel M, von Knebel Doeberitz M (December 2005). "Clonal history of papillomavirus-induced dysplasia in the female lower genital tract". J. Natl. Cancer Inst. 97 (24): 1816–21. doi:10.1093/jnci/dji428. PMID 16368943.