Syphilis history and symptoms

Revision as of 02:58, 5 November 2016 by Aysha Aslam (talk | contribs)
Jump to navigation Jump to search

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]Nate Michalak, B.A.

Sexually transmitted diseases Main Page

Syphilis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Syphilis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Primary and Secondary Syphilis
Latent Syphilis
Tertiary Syphilis
Neurosyphilis
HIV-Infected Patients
Pregnancy
Management of Sexual Partners

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Syphilis history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Syphilis history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Syphilis history and symptoms

CDC on Syphilis history and symptoms

Syphilis history and symptoms in the news

Blogs on Syphilis history and symptoms

Directions to Hospitals Treating Syphilis

Risk calculators and risk factors for Syphilis history and symptoms

Overview

The history and symptoms of syphilis depends on stage of disease. The hallmark of syphilis infection is painless chancre. A positive history of painless chancre on genitalia, and presence of risk factors such as unprotected sex, multiple sexual partners, residence in highly prevalent area and previous history of sexually transmitted infections may be suggestive of syphilis infection. The most common symptoms of syphilis infection include painless chancre which progresses to ulcer with regional lymphadenopathy in primary syphilis. Secondary syphilis is characterized by rash and constitutional symptoms. Syphilis infection in tertiary syphilis can involve any organ system, hence named the "Great Imitator".[1][2][3]

History and symptoms

The history and symptoms of syphilis according to the stage of disease are described below:[1][2][3]

Stage of syphilis History and symptoms
Primary syphilis
  • History of risk factors (MSM, unprotected sex, multiple sex partners)
  • Onset within 3 weeks of contact
  • Heals spontaneously within 4-6 weeks; however, regional lymphadenopathy may persist for longer periods
Secondary syphilis
  • Develops 6-8 weeks after the appearance of primary chancre
  • Generalized systemic symptoms such as malaise, fatigue, headache and fever may be present
  • Skin eruptions may be subtle and asymptomatic
  • Classic:
  • Non-pruritic bilateral symmetrical mucocutaneous rash
  • Non-tender regional lymphadenopathy
  • Condylomata lata
  • Patchy alopecia
Latent syphilis
  • Previous history of chancre or rash
  • Asymptomatic
Tertiary syphilis Clinical manifestation of this stage depends on organ system involved:

Neurosyphilis

Cardiovascular syphilis

Gummatous lesions

  • Presents with any organ system involved.
  • Nodular papular lesions in case of cutaneous gumma.

References

  1. 1.0 1.1 Singh AE, Romanowski B (1999). "Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features". Clin Microbiol Rev. 12 (2): 187–209. PMC 88914. PMID 10194456.
  2. 2.0 2.1 Carlson JA, Dabiri G, Cribier B, Sell S (2011). "The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity". Am J Dermatopathol. 33 (5): 433–60. doi:10.1097/DAD.0b013e3181e8b587. PMC 3690623. PMID 21694502.
  3. 3.0 3.1 Wöhrl S, Geusau A (2007). "Clinical update: syphilis in adults". Lancet. 369 (9577): 1912–4. doi:10.1016/S0140-6736(07)60895-2. PMID 17560432.


Template:WikiDoc Sources