Suppurative thrombophlebitis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The mainstay of therapy for suppurative thrombophlebitis is antimicrobial therapy. Empiric therapy includes anti-staphylococcal antibiotics plus antibiotics with coverage against enterobacteriaceae. The benefit of pharmacologic anticoagulation is uncertain in suppurative thrombophlebitis and is not routinely recommended.
Medical Therapy
Antimicrobial Regimens
- Treatment of suppurative thrombophlebitis
- 1. Bacterial pathogens
- 1.1 Gram-positive bacilli
- 1.1.1 Staphylococcus aureus
- 1.1.1.1 Methicillin-sensitive
- Preferred regimen:
- Alternative regimen:
- 1.1.1.2 Methicillin-resistant
- Preferred regimen:
- Alternative regimen:
- 1.1.2 Coagulase-negative staphylococci
- 1.1.2.1 Methicillin-sensitive
- Preferred regimen:
- Alternative regimen:
- 1.1.2.2 Methicillin-resistant
- Preferred regimen:
- Alternative regimen:
- 1.1.3 Enterococcus faecalis & Enterococcus faecium
- 1.1.3.1 Ampicillin-sensitive
- Preferred regimen:
- Alternative regimen:
- 1.1.3.2 Ampicillin-resistant & Vancomycin-sensitive
- Preferred regimen:
- Alternative regimen:
- 1.1.3.3 Ampicillin-resistant & Vancomycin-resistant
- Preferred regimen:
- Alternative regimen:
- 1.2 Gram-negative bacilli
- 1.2.1 Escherichia coli & Klebsiella spp.
- 1.2.1.1 ESBL negative
- Preferred regimen:
- Alternative regimen:
- 1.2.1.2 ESBL negative
- Preferred regimen:
- Alternative regimen:
- 1.2.2 Enterobacter spp. & Serratia marcescens
- Preferred regimen:
- Alternative regimen:
- 1.2.3 Acinetobacter spp.
- Preferred regimen:
- Alternative regimen:
- 1.2.4 Stenotrophomonas maltophilia
- Preferred regimen:
- Alternative regimen:
- 1.2.5 Pseudomonas aeruginosa
- Preferred regimen:
- Alternative regimen:
- 1.2.6 Burkholderia cepacia
- Preferred regimen:
- Alternative regimen:
- 2. Fungal pathogens
- 2.1 Candida spp.
- Preferred regimen:
- Alternative regimen:
- 3. Uncommon pathogens
- 3.1 Corynebacterium jeikeium
- Preferred regimen:
- Alternative regimen:
- 3.2 Chryseobacterium (Flavobacterium) spp.
- Preferred regimen:
- Alternative regimen:
- 3.3 Ochrobacterium anthropi
- Preferred regimen:
- Alternative regimen:
- 3.4 Malassezia furfur
- Preferred regimen:
- Alternative regimen:
- 3.5 Mycobacterium species
- Preferred regimen:
- Alternative regimen: