Secondary amyloidosis differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Secondary amyloidosis needs to be differentiated from other conditions causing nephrotic syndrome, hepatosplenomegaly, and peripheral neuropathy.

Differentiating Amyloidosis from other Diseases

Secondary amyloidosis needs to be differentiated from other conditions causing nephrotic syndrome, hepatosplenomegaly, and peripheral neuropathy.




	SIADH^[1]	Small-cell lung cancer, mesothelioma, breast, prostate, adrenal, urethral, thymoma, lymphoma, GI, CNS, and Ewing sarcoma
	Ectopic ACTH secretion^[2]	Small-cell lung cancer, carcinoid tumor, thymoma, medullary carcinoma of the thyroid and other cancers
	Tumor induced osteomalacia^[3]	Metastatic breast cancer
	Hypoglycemia^[4]	GI cancers, mesothelioma, lung, real cancer, and sarcomas
Musculocutaneous	Dermatomyositis^[5]	Breast, ovarian, lung, and prostate cancer
	Leser-Trélat sign^[6]	Gastrointestinal adenocarcinomas (gastric, colon, rectal), breast cancer, lymphoproliferative disorders/lymphoma, and melanoma.
	Acanthosis nigricans^[5]	Gastric adenocarcinoma, endometrial cancer.
	Necrolytic migratory erythema^[7]	Glucagonoma
	Sweet's syndrome^[8]	Acute myelogenous leukemia, myeloproliferative disorders, lymphoproliferative disorders, myelodysplastic syndrome, and carcinoma
	Pyoderma gangrenosum^[9]	Rectal Adenocarcinoma, myeloproliferative disorders, colon cancer
Neurological^[10]	Paraneoplastic cerebellar degeneration^[11]

		Lung cancer


	Encephalitis	Teratoma
	Polymyositis
	Autonomic neuropathy^[12]	Carcinomas,small cell lung cancer, thymoma
	Lambert-Eaton myasthenic syndrome (LEMS)	Small-cell lung cancer, prostate cancer, lymphomas, adenocarcinomas
	Myasthenia gravis	Thymoma

References

↑ Raftopoulos, Harry (2007). "Diagnosis and management of hyponatremia in cancer patients". Supportive Care in Cancer. 15 (12): 1341–1347. doi:10.1007/s00520-007-0309-9. ISSN 0941-4355.
↑ Barbosa, Sandrine Laboureau-Soares; Rodien, Patrice; Leboulleux, Sophie; Niccoli-Sire, Patricia; Kraimps, Jean-Louis; Caron, Philippe; Archambeaud-Mouveroux, Françoise; Conte-Devolx, Bernard; Rohmer, Vincent (2005). "Ectopic Adrenocorticotropic Hormone-Syndrome in Medullary Carcinoma of the Thyroid: A Retrospective Analysis and Review of the Literature". Thyroid. 15 (6): 618–623. doi:10.1089/thy.2005.15.618. ISSN 1050-7256.
↑ Florenzano, Pablo; Gafni, Rachel I.; Collins, Michael T. (2017). "Tumor-induced osteomalacia". Bone Reports. 7: 90–97. doi:10.1016/j.bonr.2017.09.002. ISSN 2352-1872.
↑ Nauck, Michael A.; Reinecke, Manfred; Perren, Aurel; Frystyk, Jan; Berishvili, Giorgi; Zwimpfer, Cornelia; Figge, Anja M.; Flyvbjerg, Allan; Lankisch, Paul G.; Blum, Werner F.; Klöppel, Günter; Schmiegel, Wolff; Zapf, Jürgen (2007). "Hypoglycemia due to Paraneoplastic Secretion of Insulin-Like Growth Factor-I in a Patient with Metastasizing Large-Cell Carcinoma of the Lung". The Journal of Clinical Endocrinology & Metabolism. 92 (5): 1600–1605. doi:10.1210/jc.2006-2573. ISSN 0021-972X.
↑ ^5.0 ^5.1 Thiers, B. H.; Sahn, R. E.; Callen, J. P. (2009). "Cutaneous Manifestations of Internal Malignancy". CA: A Cancer Journal for Clinicians. 59 (2): 73–98. doi:10.3322/caac.20005. ISSN 0007-9235.
↑ Gaduputi, Vinaya; Chandrala, Chaitanya; Tariq, Hassan; Kanneganti, Kalyan (2014). "Sign of Leser-Trélat Associated with Esophageal Squamous Cell Cancer". Case Reports in Oncological Medicine. 2014: 1–3. doi:10.1155/2014/825929. ISSN 2090-6706.
↑ Tremblay, Catherine; Marcil, Isabelle (2017). "Necrolytic Migratory Erythema: A Forgotten Paraneoplastic Condition". Journal of Cutaneous Medicine and Surgery. 21 (6): 559–561. doi:10.1177/1203475417719051. ISSN 1203-4754.
↑ Cohen, Philip R.; Kurzrock, Razelle (1987). "Sweet's syndrome and malignancy". The American Journal of Medicine. 82 (6): 1220–1226. doi:10.1016/0002-9343(87)90229-4. ISSN 0002-9343.
↑ You, Hye Rin; Ju, Jae-Kyun; Yun, Sook Jung; Lee, Jee-Bum; Kim, Seong-Jin; Won, Young Ho; Lee, Seung-Chul (2018). "Paraneoplastic Pyoderma Gangrenosum Associated with Rectal Adenocarcinoma". Annals of Dermatology. 30 (1): 79. doi:10.5021/ad.2018.30.1.79. ISSN 1013-9087.
↑ Pelosof, Lorraine C.; Gerber, David E. (2010). "Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment". Mayo Clinic Proceedings. 85 (9): 838–854. doi:10.4065/mcp.2010.0099. ISSN 0025-6196.
↑ Abdulaziz, Ammar Taha Abdullah; Yu, Xiao Qing; Zhang, Le; Jiang, Xin Yue; Zhou, Dong; Li, Jin Mei (2018). "Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism". Medicine. 97 (24): e10717. doi:10.1097/MD.0000000000010717. ISSN 0025-7974.
↑ "Paraneoplastic autonomic neuropathy: a case report | GM".

[Raftopoulos2007-1] Raftopoulos, Harry (2007). "Diagnosis and management of hyponatremia in cancer patients". Supportive Care in Cancer. 15 (12): 1341–1347. doi:10.1007/s00520-007-0309-9. ISSN 0941-4355.

[BarbosaRodien2005-2] Barbosa, Sandrine Laboureau-Soares; Rodien, Patrice; Leboulleux, Sophie; Niccoli-Sire, Patricia; Kraimps, Jean-Louis; Caron, Philippe; Archambeaud-Mouveroux, Françoise; Conte-Devolx, Bernard; Rohmer, Vincent (2005). "Ectopic Adrenocorticotropic Hormone-Syndrome in Medullary Carcinoma of the Thyroid: A Retrospective Analysis and Review of the Literature". Thyroid. 15 (6): 618–623. doi:10.1089/thy.2005.15.618. ISSN 1050-7256.

[FlorenzanoGafni2017-3] Florenzano, Pablo; Gafni, Rachel I.; Collins, Michael T. (2017). "Tumor-induced osteomalacia". Bone Reports. 7: 90–97. doi:10.1016/j.bonr.2017.09.002. ISSN 2352-1872.

[NauckReinecke2007-4] Nauck, Michael A.; Reinecke, Manfred; Perren, Aurel; Frystyk, Jan; Berishvili, Giorgi; Zwimpfer, Cornelia; Figge, Anja M.; Flyvbjerg, Allan; Lankisch, Paul G.; Blum, Werner F.; Klöppel, Günter; Schmiegel, Wolff; Zapf, Jürgen (2007). "Hypoglycemia due to Paraneoplastic Secretion of Insulin-Like Growth Factor-I in a Patient with Metastasizing Large-Cell Carcinoma of the Lung". The Journal of Clinical Endocrinology & Metabolism. 92 (5): 1600–1605. doi:10.1210/jc.2006-2573. ISSN 0021-972X.

[ThiersSahn2009-5] 5.0 ^5.1 Thiers, B. H.; Sahn, R. E.; Callen, J. P. (2009). "Cutaneous Manifestations of Internal Malignancy". CA: A Cancer Journal for Clinicians. 59 (2): 73–98. doi:10.3322/caac.20005. ISSN 0007-9235.

[GaduputiChandrala2014-6] Gaduputi, Vinaya; Chandrala, Chaitanya; Tariq, Hassan; Kanneganti, Kalyan (2014). "Sign of Leser-Trélat Associated with Esophageal Squamous Cell Cancer". Case Reports in Oncological Medicine. 2014: 1–3. doi:10.1155/2014/825929. ISSN 2090-6706.

[TremblayMarcil2017-7] Tremblay, Catherine; Marcil, Isabelle (2017). "Necrolytic Migratory Erythema: A Forgotten Paraneoplastic Condition". Journal of Cutaneous Medicine and Surgery. 21 (6): 559–561. doi:10.1177/1203475417719051. ISSN 1203-4754.

[CohenKurzrock1987-8] Cohen, Philip R.; Kurzrock, Razelle (1987). "Sweet's syndrome and malignancy". The American Journal of Medicine. 82 (6): 1220–1226. doi:10.1016/0002-9343(87)90229-4. ISSN 0002-9343.

[YouJu2018-9] You, Hye Rin; Ju, Jae-Kyun; Yun, Sook Jung; Lee, Jee-Bum; Kim, Seong-Jin; Won, Young Ho; Lee, Seung-Chul (2018). "Paraneoplastic Pyoderma Gangrenosum Associated with Rectal Adenocarcinoma". Annals of Dermatology. 30 (1): 79. doi:10.5021/ad.2018.30.1.79. ISSN 1013-9087.

[PelosofGerber2010-10] Pelosof, Lorraine C.; Gerber, David E. (2010). "Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment". Mayo Clinic Proceedings. 85 (9): 838–854. doi:10.4065/mcp.2010.0099. ISSN 0025-6196.

[AbdulazizYu2018-11] Abdulaziz, Ammar Taha Abdullah; Yu, Xiao Qing; Zhang, Le; Jiang, Xin Yue; Zhou, Dong; Li, Jin Mei (2018). "Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism". Medicine. 97 (24): e10717. doi:10.1097/MD.0000000000010717. ISSN 0025-7974.

[urlParaneoplastic_autonomic_neuropathy:_a_case_report_|_GM-12] "Paraneoplastic autonomic neuropathy: a case report | GM".

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Secondary amyloidosis differential diagnosis

Overview

Differentiating Amyloidosis from other Diseases

References

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