Prostate cancer screening

Revision as of 13:53, 16 September 2015 by Shanshan Cen (talk | contribs)
Jump to navigation Jump to search

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Prostate cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Prostate Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Staging

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Biopsy

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Alternative Therapy

Case Studies

Case #1

Prostate cancer screening On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Prostate cancer screening

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Prostate cancer screening

CDC on Prostate cancer screening

Prostate cancer screening in the news

Blogs on Prostate cancer screening

Directions to Hospitals Treating Prostate cancer

Risk calculators and risk factors for Prostate cancer screening

Overview

According to the AUA guidline, screening for prostate cancer by PSA is recommended every 2 years among individuals age 55 to 69 years, or younger than 55 years for individuals with high risk.[1]

Screening

Prostate cancer screening is an attempt to find unsuspected cancers. Screening tests may lead to more specific follow-up tests such as a biopsy, where small cores of the prostate are removed for closer study. Prostate cancer screening options include the digital rectal exam and the prostate specific antigen (PSA) blood test. Screening for prostate cancer is controversial because it is not clear if the benefits of screening outweigh the risks of follow-up diagnostic tests and cancer treatments.

Prostate cancer is usually a slow-growing cancer, very common among older men. In fact, most prostate cancers never grow to the point where they cause symptoms, and most men with prostate cancer die of other causes before prostate cancer has an impact on their lives. The PSA screening test may detect these small cancers that would never become life threatening. Doing the PSA test in these men may lead to overdiagnosis, including additional testing and treatment. Follow-up tests, such as prostate biopsy, may cause pain, bleeding and infection. Prostate cancer treatments may cause urinary incontinence and erectile dysfunction. Therefore, it is essential that the risks and benefits of diagnostic procedures and treatment be carefully considered before PSA screening.

Several medical societies have not found sufficient evidence to support routine screening for prostate cancer - but the American Urological Association supports annual screening and digital examination for men over 50 years old - and starting earlier for 'men at high risk (those with a family history of prostate cancer or African American men)'. [2]

  • In 2002, the U.S. Preventive Services Task Force (USPSTF) concluded that the evidence was insufficient to recommend for or against routine screening for prostate cancer using PSA testing or digital rectal examination (DRE).[3] The previous 1995 USPSTF recommendation was against routine screening.
  • In 1997, American Cancer Society (ACS) guidelines began recommending that beginning at age 50 (age 45 for African-American men and men with a family history of prostate cancer, and since 2001, age 40 for men with a very strong family history of prostate cancer), PSA testing and DRE be offered annually to men who have a life-expectancy of 10 or more years (average life expectancy is 10 years or more for U.S. men under age 76)[4]along with information on the risks and benefits of screening.[5] The previous ACS recommendations since 1980 had been for routine screening for prostate cancer with DRE annually beginning at age 40, and since 1992 had been for routine screening with DRE and PSA testing annually beginning at age 50.[6]
  • The 2007 National Comprehensive Cancer Network (NCCN) guideline recommends offering a baseline PSA test and DRE at ages 40 and 45 and annual PSA testing and DRE beginning at age 50 (with annual PSA testing and DRE beginning at age 40 for African-American men, men with a family history of prostate cancer, and men with a PSA ≥ 0.6 ng/mL at age 40 or PSA > 0.6 ng/mL at age 45) through age 80, along with information on the risks and benefits of screening. Biopsy is recommended if DRE is positive or PSA ≥ 4 ng/mL, and biopsy considered if PSA > 2.5 ng/mL or PSA velocity ≥ 0.35 ng/mL/year when PSA ≤ 2.5 ng/mL.[7]
  • Some U.S. radiation oncologists and medical oncologists who specialize in treating prostate cancer recommend obtaining a baseline PSA in all men at age 35.[8] or beginning annual PSA testing in high risk men at age 35.[9]
  • The American Urological Association Patient Guide to Prostate Cancer.[10]

Since there is no general agreement that the benefits of PSA screening outweigh the harms, the consensus is that clinicians use a process of shared decision-making that includes discussing with patients the risks of prostate cancer, the potential benefits and harms of screening, and involving the patients in the decision.[11]

However, because PSA screening is widespread in the United States, following the recommendations of major scientific and medical organizations to use shared decision-making is legally perilous in some U.S. states.[12] In 2003, a Virginia jury found a family practice residency program guilty of malpractice and liable for $1 million for following national guidelines and using shared decision-making, thereby allowing a patient (subsequently found to have a high PSA and incurable advanced prostate cancer) to decline a screening PSA test, instead of routinely ordering without discussion PSA tests in all men ≥ 50 years of age as four local physicians testified was their practice, and was accepted by the jury as the local standard of care.[13]

An estimated 20 million PSA tests are done per year in North America and possibly 20 million more outside of North America.[14]

  • In 2000, 34.1% of all U.S. men age ≥ 50 had a screening PSA test within the past year and 56.8% reported ever having a PSA test.[11]
  • In 2000, 33.6% of all U.S. men age 50–64 and 51.3% of men age ≥ 65 had a PSA test within the past year.[15]
  • In 2005, 33.5% of all U.S. men age 50–64 had a PSA test in the past year.
    • 37.5% of men with private health insurance, 20.8% of men with Medicaid insurance, 14.0% of currently uninsured men, and 11.5% of men uninsured for > 12 months.[16]
  • In 2000–2001, 34.1% of all Canadian men age ≥ 50 had a screening PSA test within the past year and 47.5% reported ever having a screening PSA test.[17]
  • Canadian men in Ontario were most likely to have had a PSA test within the past year and men in Alberta were least likely to have had a PSA test with the past year or ever.[18]

Screening Methods

Digital Rectal Examination

Digital rectal examination (DRE) is a procedure where the examiner inserts a gloved, lubricated finger into the rectum to check the size, shape, and texture of the prostate. Areas which are irregular, hard or lumpy need further evaluation, since they may contain cancer. Although the DRE only evaluates the back of the prostate, 85% of prostate cancers arise in this part of the prostate. Prostate cancer which can be felt on DRE is generally more advanced.[19] The use of DRE has never been shown to prevent prostate cancer deaths when used as the only screening test.[20]

Prostate Specific Antigen

Main article: Prostate specific antigen

The PSA test measures the blood level of prostate-specific antigen, an enzyme produced by the prostate. Specifically, PSA is a serine protease similar to kallikrein. Its normal function is to liquify gelatinous semen after ejaculation, allowing spermatozoa to more easily navigate through the uterine cervix.

The risk of prostate cancer increases with increasing PSA levels.[21] 4 ng/mL was chosen arbitrarily as a decision level for biopsies in the clinical trial upon which the FDA in 1994 based adding prostate cancer detection in men age 50 and over as an approved indication for the first commercially available PSA test.[22] 4 ng/mL was used as the biopsy decision level in the PLCO trial, 3 ng/mL was used in the ERSPC and ProtecT trials, and 2.5 ng/mL is used in the 2007 NCCN guideline.

PSA levels can change for many reasons other than cancer. Two common causes of high PSA levels are enlargement of the prostate (benign prostatic hypertrophy (BPH)) and infection in the prostate (prostatitis). It can also be raised for 24 hours after ejaculation and several days after catheterization. PSA levels are lowered in men who use medications used to treat BPH or baldness. These medications, finasteride (marketed as Proscar or Propecia) and dutasteride (marketed as Avodart), may decrease the PSA levels by 50% or more.

Several other ways of evaluating the PSA have been developed to avoid the shortcomings of simple PSA screening. The use of age-specific reference ranges improves the sensitivity and specificity of the test. The rate of rise of the PSA over time, called the PSA velocity, has been used to evaluate men with PSA levels between 4 and 10 ng/ml, but it has not proven to be an effective screening test.[23] Comparing the PSA level with the size of the prostate, as measured by ultrasound or magnetic resonance imaging, has also been studied. This comparison, called PSA density, is both costly and has not proven to be an effective screening test.[24] PSA in the blood may either be free or bound to other proteins. Measuring the amount of PSA which is free or bound may provide additional screening information, but questions regarding the usefulness of these measurements limit their widespread use.[25][26]

Interpreting the results of Screening Tests

Two clinical prediction rules help predict the probability of cancer based on the the level of the prostate-specific antigen and other clinical findings.[27][28]

Evidence for Efficacy

Randomized Controlled Trials

One randomized controlled trial found significant reduction in death from screening.[29] However, the intention to treat analysis showed no benefit.

A secondary analysis of a randomized controlled trial suggests screening for prostate cancer every 4 years is adequate. The screening comprises a PSA blood test, a digital rectal exam, and a transrectal ultrasound. "Very few, if any, aggressive prostate cancers escape (this) screening."[30]

When all available trials are meta-analyzed, mortality from prostate cancer may be reduced among patients with sufficient duration of screening (see Forest plot) .[31]

Decision Analyses

In the absence of well done randomized controlled trials, a decision analysis can estimate the benefit of screening. [32][33] One analysis found that approximately 303 men would number need to be screened with a "strategy of PSA testing at ages 40 and 45 years followed by biennial testing beginning at age 50" to prevent one death from prostate cancer.[33]

Clinical Practice Guidelines

Clinical practice guidelines for prostate cancer screening are controversial because the benefits of screening may not outweigh the risks of follow-up diagnostic tests and cancer treatments:

"the evidence is insufficient to recommend for or against routine screening for prostate cancer using prostate-specific antigen (PSA) testing or digital rectal examination (DRE). This is a grade I recommendation"
"The PSA test and the DRE should be offered annually beginning at age 50 to men who have a life expectancy of at least 10 years. Men at high risk should begin testing at age 45. Information should be provided to patients about benefits and limitations of testing."

The ACS recommends that individual men discuss the potential benefits and risks of testing with their doctors in order to make an informed decision on whether or not to be tested. Screening should be offered annually to African-American men and those with a family history of prostate cancer upon reaching 45 years. Other racial and ethnic groups, such as Asian- and Hispanic-Americans have a lower risk of prostate cancer, and may not benefit from screening. Screening is likely not useful for men over age 70 or with other significant medical problems and a life expectancy of fewer than 10 years.


References

  1. ↑ Carter HB (2013). "American Urological Association (AUA) guideline on prostate cancer detection: process and rationale". BJU Int. 112 (5): 543–7. doi:10.1111/bju.12318. PMID 23924423.
  2. ↑ Early Detection of Prostate Cancer, American Urological Association, Washington, D.C., revised: October 2008.Accessed: 12-01-2008
  3. ↑ US Preventive Services Task Force (2002). "Screening for Prostate Cancer". Agency for Healthcare Research and Quality. Unknown parameter |month= ignored (help) USPSTF (2002). "Screening for prostate cancer: recommendation and rationale" (PDF). Ann Intern Med. 137 (11): 915–6. PMID 12458992. Unknown parameter |month= ignored (help)
    Harris R, Lohr KN (2002). "Screening for prostate cancer: an update of the evidence for the U.S. Preventive Services Task Force" (PDF). Ann Intern Med. 137 (11): 917–29. PMID 12458993. Unknown parameter |month= ignored (help)
  4. ↑ Arias E (2006). "United States Life Tables, 2003" (PDF). Natl Vital Stat Rep. 54 (14): 1–40. PMID 16681183. Unknown parameter |month= ignored (help)
  5. ↑ von Eschenbach A, Ho R, Murphy GP, Cunningham M, Lins N (1997). "American Cancer Society guideline for the early detection of prostate cancer: update 1997" (PDF). CA Cancer J Clin. 47 (5): 261–4. doi:10.3322/canjclin.47.5.261. PMID 9314820. Unknown parameter |month= ignored (help)ACS (2007). "Prostate Cancer: Early Detection". Retrieved 2007-11-19. Unknown parameter |month= ignored (help)
    Smith RA, Cokkinides V, Eyre HJ (2007). "Cancer screening in the United States, 2007: a review of current guidelines, practices, and prospects" (PDF). CA Cancer J Clin. 57 (2): 90–104. PMID 17392386. Unknown parameter |month= ignored (help)
    Smith RA, Cokkinides V, Eyre HJ (2006). "American Cancer Society guidelines for the early detection of cancer, 2006" (PDF). CA Cancer J Clin. 56 (1): 11–25. PMID 16449183. Unknown parameter |month= ignored (help)
  6. ↑ ACS (2007). "Chronological History of ACS Recommendations on Early Detection of Cancer". Unknown parameter |month= ignored (help)
  7. ↑ NCCN (2007). "Prostate Cancer Early Detection V.2.2007" (PDF). NCCN Clinical Practice Guidelines in Oncology. Unknown parameter |month= ignored (help)
  8. ↑ "Study suggests value of regular PSA tests for tracking prostate cancer". Dana-Farber Cancer Institute. 2004. Unknown parameter |month= ignored (help) Kladko B (2005). "Prostate cancer test gets another look". The Boston Globe. Unknown parameter |month= ignored (help)
  9. ↑ Strum SB, Pogliano D (2005). "What every doctor who treats male patients should know" (PDF). PCRI Insights. 8 (2): 4–5. Unknown parameter |month= ignored (help)
  10. ↑ American Urological Association (AUA) (2008). "Prostate Cancer Patient Guide" (PDF). AUA Patient Guidelines.
  11. ↑ 11.0 11.1 Ross LE, Coates RJ, Breen N, Uhler RJ, Potosky AL, Blackman D (2004). "Prostate-specific antigen test use reported in the 2000 National Health Interview Survey". Prev Med. 38 (6): 732–44. doi:10.1016/j.ypmed.2004.01.005. PMID 15193893.
  12. ↑ Lewis MH, Gohagan JK, Merenstein DJ (2007). "The locality rule and the physician's dilemma: local medical practices vs the national standard of care". JAMA. 297 (23): 2633–7. doi:10.1001/jama.297.23.2633. PMID 17579232.
  13. ↑ Merenstein D (2004). "Winners and losers". JAMA. 291 (1): 15–6. doi:10.1001/jama.291.1.15. PMID 14709561.
  14. ↑ De Angelis G, Rittenhouse HG, Mikolajczyk SD, Blair Shamel L, Semjonow A (2007). "Twenty years of PSA: from prostate antigen to tumor marker". Rev Urol. 9 (3): 113–23. PMID 17934568.
  15. ↑ Swan J, Breen N, Coates RJ, Rimer BK, Lee NC (2003). "Progress in cancer screening practices in the United States: results from the 2000 National Health Interview Survey". Cancer. 97 (6): 1528–40. doi:10.1002/cncr.11208. PMID 12627518.
  16. ↑ Ward E, Halpern M, Schrag N, Cokkinides V, DeSantis C, Bandi P, Siegel R, Stewart A, Jemal A (2008). "Association of insurance with cancer care utilization and outcomes" (PDF). CA Cancer J Clin. 58 (1): 9–31. doi:10.3322/CA.2007.0011. PMID 18096863. Unknown parameter |month= ignored (help)
  17. ↑ Beaulac JA, Fry RN, Onysko J (2006). "Lifetime and recent prostate specific antigen (PSA) screening of men for prostate cancer in Canada". Can J Public Health. 97 (3): 171–6. PMID 16827400.
  18. ↑ Gibbons L, Waters C (2003). "Prostate cancer--testing, incidence, surgery and mortality" (PDF). Health Rep. 14 (3): 9–20. PMID 12816012. Unknown parameter |month= ignored (help)
  19. ↑ Chodak, GW (1989). "Assessment of screening for prostate cancer using the digital rectal examination". J Urol. 141 (5): 1136–8. PMID 2709500. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)
  20. ↑ Krahn, MD (1994). "Screening for prostate cancer.. A decision analytic view". JAMA. 272 (10): 773–80. doi:10.1001/jama.272.10.773. PMID 7521400. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)
  21. ↑ Catalona WJ (2007). "How I manage a patient with a newly elevated PSA" (PDF). 2007 CDC Cancer Conference. Unknown parameter |month= ignored (help)
  22. ↑ Kolota G (2004). "It was medical gospel, but it wasn't true". The New York Times: 4.7. Unknown parameter |month= ignored (help)
    Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, Minasian LM, Ford LG, Lippman SM, Crawford ED, Crowley JJ, Coltman CA Jr (2004). "Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter". N Engl J Med. 350 (22): 2239–46. PMID 15163773. Unknown parameter |month= ignored (help)
    Carter HB (2004). "Prostate cancers in men with low PSA levels--must we find them?". N Engl J Med. 350 (22): 2292–4. doi:10.1056/NEJMe048003. PMID 15163780. Unknown parameter |month= ignored (help)
    Catalona WJ, Richie JP, Ahmann FR, Hudson MA, Scardino PT, Flanigan RC, deKernion JB, Ratliff TL, Kavoussi LR, Dalkin BL; et al. (1994). "Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men". J Urol. 151 (5): 1283–90. PMID 7512659. Unknown parameter |month= ignored (help)
    FDA (1994). "FDA approves test for prostate cancer". Unknown parameter |month= ignored (help)
  23. ↑ Roobol, MJ (2004). "Prostate-specific antigen velocity at low prostate-specific antigen levels as screening tool for prostate cancer: results of second screening round of ERSPC (ROTTERDAM)". Urology. 63 (2): 309–13, discussion 313–5. doi:10.1016/j.urology.2003.09.083. PMID 14972478. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)
  24. ↑ Catalona, WJ (1994). "Comparison of prostate specific antigen concentration versus prostate specific antigen density in the early detection of prostate cancer: receiver operating characteristic curves". J Urol. 152 (6 Pt 1): 2031–6. PMID 7525994. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)
  25. ↑ Hoffman, RM (2000). "Using the free-to-total prostate-specific antigen ratio to detect prostate cancer in men with nonspecific elevations of prostate-specific antigen levels". J Gen Intern Med. 15 (10): 739–48. doi:10.1046/j.1525-1497.2000.90907.x. PMID 11089718. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)
  26. ↑ Partin, AW (2003). "Complexed prostate specific antigen improves specificity for prostate cancer detection: results of a prospective multicenter clinical trial". J Urol. 170 (5): 1787–91. doi:10.1097/01.ju.0000092695.55705.dd. PMID 14532777. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)
  27. ↑ Nam RK, Toi A, Klotz LH; et al. (2007). "Assessing individual risk for prostate cancer". J. Clin. Oncol. 25 (24): 3582–8. doi:10.1200/JCO.2007.10.6450. PMID 17704405.
  28. ↑ Thompson IM, Ankerst DP, Chi C; et al. (2006). "Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial". J. Natl. Cancer Inst. 98 (8): 529–34. doi:10.1093/jnci/djj131. PMID 16622122. Online calculator
  29. ↑ Labrie F, Candas B, Dupont A; et al. (1999). "Screening decreases prostate cancer death: first analysis of the 1988 Quebec prospective randomized controlled trial". Prostate. 38 (2): 83–91. PMID 9973093.
  30. ↑ Schröder F, Raaijmakers R, Postma R, van der Kwast T, Roobol M (2005). "4-year prostate specific antigen progression and diagnosis of prostate cancer in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam". J Urol. 174 (2): 489–94, discussion 493-4. PMID 16006878.
  31. ↑ Prostate cancer screening with prostate specific antigen: a living systematic review. GitHub. Available at http://openmetaanalysis.github.io/Prostate-cancer-screening-with-prostate-specific-antigen/. Accessed June 14, 2015
  32. ↑ Krahn MD, Mahoney JE, Eckman MH, Trachtenberg J, Pauker SG, Detsky AS (1994). "Screening for prostate cancer. A decision analytic view". JAMA. 272 (10): 773–80. PMID 7521400.
  33. ↑ 33.0 33.1 Ross KS, Carter HB, Pearson JD, Guess HA (2000). "Comparative efficiency of prostate-specific antigen screening strategies for prostate cancer detection". JAMA. 284 (11): 1399–405. PMID 10989402.
  34. ↑ U.S. Preventive Services Task Force (2002). "Screening for prostate cancer: recommendation and rationale". Ann. Intern. Med. 137 (11): 915–6. PMID 12458992.
  35. ↑ Harris R, Lohr KN (2002). "Screening for prostate cancer: an update of the evidence for the U.S. Preventive Services Task Force". Ann. Intern. Med. 137 (11): 917–29. PMID 12458993.
  36. ↑ U.S. Preventive Services Task Force (December 2002)). "Screening for Prostate Cancer". Retrieved 2006-09-14. Check date values in: |date= (help)
  37. ↑ Smith RA, von Eschenbach AC, Wender R; et al. (2001). "American Cancer Society guidelines for the early detection of cancer: update of early detection guidelines for prostate, colorectal, and endometrial cancers. Also: update 2001--testing for early lung cancer detection". CA: a cancer journal for clinicians. 51 (1): 38–75, quiz 77-80. PMID 11577479.
  38. ↑ National Guideline Clearinghouse. "Recommendations from the American Cancer Society Workshop on Early Prostate Cancer Detection". Retrieved 2006-09-14.
  39. ↑ American Cancer Society. "What the American Cancer Society Recommends". Retrieved 2007-01-16.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Prostate_cancer_screening&oldid=1156940"