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==Overview==
==Overview==
The exact pathogenesis of [disease name] is not fully understood.
The exact [[pathogenesis]] of [[personality disorder]] is not fully understood. Personality disorders are related to multifactorial causes. Throughout time, a multitude of theories has been developed to explain the origin of these [[disorders]]. However still, the [[pathophysiology]] of PDs remains enigmatic. The [[five-factor model]] of personality was developed in the 1980s and 1990s, which demonstrated that it comprises five distinct traits. PDs are primarily the result of positive [[correlation]] with [[Neuroticism]] and negative association with [[Agreeableness]]. [[Extraversion]] is associated in both ways. It is a well-known fact that [[personality]] develops during [[childhood]] and [[interpersonal]] experiences and social interactions play a significant role in the development of PDs. Parental [[maltreatment]], [[stress]], and traumatic life events influence the personality adversely. In addition, [[genetic]] and [[prenatal]] factors also constitute a major role. [[Genetic]] factors with [[mutations]] in genes involving [[dopamine]] and [[serotonin]] pathways such as DRD2, [[COMT]], DTNBP1, DAAO, 5-[[HTTLPR]], [[MAOA]], DRD3,[[TPH1]] and [[TPH2|TPH2.]] [[Perinatal]] injuries like [[trauma]], infections like [[encephalitis]], and [[hemorrhage]] may also be contributing factors. Genetic factors interact with environmental stresses to result in PDs. Various parental behavior like excessive [[Attachment (psychology)|attachment]], parental insensitivity or [[emotional]] neglect, physical and sexual [[abuse]], and [[substance use disorders]] causes an essential impact on PDs development. Social bullying, racial [[discrimination]], frequent dislocations during childhood, and lack of [[peer support]] are other [[risk factors]].
 
OR
 
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
 
OR
 
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
 
OR
 
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
 
OR
 
 
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
 
OR
 
The progression to [disease name] usually involves the [molecular pathway].
 
OR
 
The pathophysiology of [disease/malignancy] depends on the histological subtype.


==Pathophysiology==
==Pathophysiology==
===Physiology===
===Physiology===
The personality development is a dynamic process that starts early in life and continue to evolve and change when subjected to environmental factors and consequential events. It results in establishing an organised pattern of behaviours and attitudes which are unique to every individual.
The [[personality development]] is a dynamic process that starts early in life and continue to evolve and change when subjected to environmental factors and consequential events. It results in establishing an organized pattern of behaviors and attitudes which are unique to every individual.


The theories to explain personality development has been presented throughout time. [[Freud's Psychoanalytic Theory]] was the pioneer. As discussed in historical perspectives, it is based on ideas of the [[id]], the [[ego]] and the [[superego]]. The interaction and conflict among these is responsible for the creating the personality in an individual. He also proposed five stages of [[psychosexual]] development. Following it, [[new-Freudians]] (followers of Feud) elaborated the concept of Feud to formulate many new theories. However, the major problem was lack of ways to test the theories on wide variety of patients due to differences in dealings by different individuals and due to vague predictions made by it regarding [[defence mechanisms]]. Thus, it fails to pass [[empiricism]]. The [[five-factor theory/model]] is a remarkable widely-accepted model of personality development. It suggests personality constitutes of five traits; [[Conscientiousness]], [[Agreeableness]], [[Neuroticism]], [[Openness to Experience]], and [[Extraversion]]. Each personality trait is a spectrum and an individual can fall anywhere on this scale. The other trait theories just utilised binary values instead of a continuum. Each trait is influenced by genetic and environmental factors. The biological theories explain this as well.
The theories to explain [[personality]] development has been presented throughout time. [[Freud's Psychoanalytic Theory]] was the pioneer. As discussed in historical perspectives, it is based on ideas of the [[id]], the [[ego]] and the [[superego]].<ref name="pmid21694972">{{cite journal| author=De Sousa A| title=Freudian theory and consciousness: a conceptual analysis**. | journal=Mens Sana Monogr | year= 2011 | volume= 9 | issue= 1 | pages= 210-7 | pmid=21694972 | doi=10.4103/0973-1229.77437 | pmc=3115290 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21694972  }} </ref> The interaction and conflict among these is responsible for the creating the personality in an individual. He also proposed five stages of [[psychosexual]] [[development]]. Following it, [[new-Freudians]] (followers of Feud) elaborated the concept of Feud to formulate many new theories. However, the major problem was lack of ways to test the theories on wide variety of patients due to differences in dealings by different individuals and due to vague predictions made by it regarding [[defence mechanisms|defense mechanisms]]. Thus, it fails to pass [[empiricism]]. The [[five-factor theory/model]] is a remarkable widely-accepted model of personality development. It suggests [[personality]] constitutes of five traits; [[Conscientiousness]], [[Agreeableness]], [[Neuroticism]], [[Openness to Experience]], and [[Extraversion]]. <ref name="pmid31496109">{{cite journal| author=Widiger TA, Crego C| title=The Five Factor Model of personality structure: an update. | journal=World Psychiatry | year= 2019 | volume= 18 | issue= 3 | pages= 271-272 | pmid=31496109 | doi=10.1002/wps.20658 | pmc=6732674 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31496109  }} </ref> Each personality trait is a [[spectrum]] and an individual can fall anywhere on this scale. The other trait theories just utilized binary values instead of a continuum. Each trait is influenced by [[genetic]] and environmental factors. The [[biological]] theories explain this as well.


===Pathogenesis===
===Pathogenesis===
Throughout time, a multitude of theories has been developed to explain the origin of these disorders. However still, the [[pathophysiology]] of PDs remains enigmatic. The [[five-factor model]] of personality was developed in the 1980s and 1990s, which demonstrated that it comprises five distinct traits. These include [[extraversion]], [[Neuroticism]], openness to experience/intellect, [[Agreeableness]], and [[conscientiousness]]. A meta-analysis conducted by [[Saulsman]] and [[Page]] in 2004 reveals the association of personality disorders with the five-trait model. It concludes that [[extraversion]] is positively associated with disorders characterizing assertiveness or gregariousness like [[Histrionic]] and [[Narcissist]]. [[Neuroticism]] is positively associated with disorders causing emotional distress like [[Paranoid]], [[Schizotypal]], [[Borderline]], [[Dependent]], and [[Avoidant]]. [[Agreeableness]] is negatively associated with disorders characterized by interpersonal difficulties like [[Paranoid]], [[Schizotypal]], [[Antisocial]], [[Borderline]], and [[Narcissist]]. Those disorders which are distinguished by orderliness are positively associated with [[conscientiousness]], like [[Obsessive-compulsive disorder]]. [[Schizoid]] is negatively associated with [[extraversion]]. Hence, PDs are primarily the result of positive correlation with [[Neuroticism]] and negative association with [[Agreeableness]]. [[Extraversion]] is associated in both ways <ref name="pmid14729423">{{cite journal| author=Saulsman LM, Page AC| title=The five-factor model and personality disorder empirical literature: A meta-analytic review. | journal=Clin Psychol Rev | year= 2004 | volume= 23 | issue= 8 | pages= 1055-85 | pmid=14729423 | doi=10.1016/j.cpr.2002.09.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14729423  }} </ref>. This remains the most widely accepted explanation for development of personality disorder. Other theories are as follows:
Throughout time, a multitude of theories has been developed to explain the origin of these disorders. However still, the [[pathophysiology]] of PDs remains enigmatic. The [[five-factor model]] of personality was developed in the 1980s and 1990s, which demonstrated that it comprises five distinct traits. These include [[extraversion]], [[Neuroticism]], openness to experience/intellect, [[Agreeableness]], and [[conscientiousness]]. A meta-analysis conducted by [[Saulsman]] and [[Page]] in 2004 reveals the association of personality disorders with the five-trait model. It concludes that [[extraversion]] is positively associated with disorders characterizing assertiveness or gregariousness like [[Histrionic]] and [[Narcissist]]. [[Neuroticism]] is positively associated with disorders causing [[emotional]] distress like [[Paranoid]], [[Schizotypal]], [[Borderline]], [[Dependent]], and [[Avoidant]]. [[Agreeableness]] is negatively associated with disorders characterized by [[interpersonal]] difficulties like [[Paranoid]], [[Schizotypal]], [[Antisocial]], [[Borderline]], and [[Narcissist]]. Those disorders which are distinguished by orderliness are positively associated with [[conscientiousness]], like [[Obsessive-compulsive disorder]]. [[Schizoid]] is negatively associated with [[extraversion]]. Hence, PDs are primarily the result of positive correlation with [[Neuroticism]] and negative association with [[Agreeableness]]. [[Extraversion]] is associated in both ways <ref name="pmid14729423">{{cite journal| author=Saulsman LM, Page AC| title=The five-factor model and personality disorder empirical literature: A meta-analytic review. | journal=Clin Psychol Rev | year= 2004 | volume= 23 | issue= 8 | pages= 1055-85 | pmid=14729423 | doi=10.1016/j.cpr.2002.09.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14729423  }} </ref>. This remains the most widely accepted explanation for development of personality disorder. Other theories are as follows:


====Object Relations Theory of Personality Disorders====
====Object Relations Theory of Personality Disorders====
[[Melanie Klein]] describes that during infant stage of life, each individual develops "internal representations" of self and others. This later results in formulating "self concept" and internal images of other people (objects). This is, in turn, responsible for "[[affects]]", which are feelings experienced in presence of others similar to ones previous "representations." The object relations refer to the internal representation of relationship of self and object and these form the building blocks for organising a person inner personality.  
[[Melanie Klein]] describes that during [[infant]] stage of life, each individual develops "[[internal]] representations" of self and others. This later results in formulating "[[Self-concept|self concept]]" and internal images of other people (objects). This is, in turn, responsible for "[[affects]]", which are [[feelings]] experienced in presence of others similar to ones previous "representations." The object relations refer to the internal representation of relationship of self and object and these form the building blocks for organizing a person inner personality. <ref name="pmid33790822">{{cite journal| author=Svrakic DM, Zorumski CF| title=Neuroscience of Object Relations in Health and Disorder: A Proposal for an Integrative Model. | journal=Front Psychol | year= 2021 | volume= 12 | issue=  | pages= 583743 | pmid=33790822 | doi=10.3389/fpsyg.2021.583743 | pmc=8005655 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33790822  }} </ref>


====Attachment Theory of Personality Disorder====
====Attachment Theory of Personality Disorder====
[[John Bowlby]] describes the person's characteristic ways of relating in close relationships. It endorses that every individual develops internal representations of relationships throughout their correspondence with early caretakers. The affective bond between infant and caregiver is responsible for developing [[interpersonal]] attitudes and relations. The adaptive attachment of a child with caregiver predicts the [[intrapsychic]] conflicts that an individual may experience later in life. This early attachment relations mold an individual to maintain an equilibrium between self regulation and stress regulation.
[[John Bowlby]] describes the person's characteristic ways of relating in close relationships. It endorses that every individual develops [[internal]] representations of relationships throughout their correspondence with early caretakers. The [[affective]] bond between infant and caregiver is responsible for developing [[interpersonal]] attitudes and relations. The adaptive attachment of a child with caregiver predicts the [[intrapsychic]] conflicts that an individual may experience later in life. This early [[Attachment (psychology)|attachment]] relations mold an individual to maintain an [[equilibrium]] between self regulation and [[Stress (medicine)|stress]] regulation. <ref name="urlAttachment Theory: Social, Developmental, and Clinical Perspectives - Google Books">{{cite web |url=https://books.google.com/books?hl=en&lr=&id=x-Oki9MxalQC&oi=fnd&pg=PR2&dq=Attachment+Theory+of+Personality+Disorder+by+john+bowlby&ots=rayROOc9vY&sig=_iuwOwbJAcc6_b5EIL1Z4AeVnU8#v=onepage&q=Attachment%20Theory%20of%20Personality%20Disorder%20by%20john%20bowlby&f=false |title=Attachment Theory: Social, Developmental, and Clinical Perspectives - Google Books |format= |work= |accessdate=}}</ref>


====Cognitive-Behavioral Theory of Personality Disorders====
====Cognitive-Behavioral Theory of Personality Disorders====
It lays the foundation of CBT which is utilised for treatment of many PDs and other psychiatric conditions these days. It is based on aspect that thoughts are responsible for emotions which predicts the behaviour. [[Core beliefs]] regarding self and others are formulated which are, in turn, responsible for thoughts, feelings and behaviour exhibited by an individual. The theory predicts that the core beliefs are influenced by the biological factors or temperament ([[Nature]]) and social environment or childhood experiences ([[Nurture]]). This infers that any distortion in core beliefs will result in deformation of personality. This supports the cognitive behavioural therapy designed as a management technique for personality disorders, which aims to create an awareness among patients of their dysfunctional core beliefs and restructure them.
It lays the foundation of [[CBT]] which is utilized for treatment of many PDs and other [[psychiatric]] conditions these days. It is based on aspect that thoughts are responsible for emotions which predicts the behavior. [[Core beliefs]] regarding self and others are formulated which are, in turn, responsible for thoughts, [[feelings]] and [[behavior]] exhibited by an individual. The theory predicts that the [[Core (anatomy)|core]] beliefs are influenced by the [[biological]] factors or temperament ([[Nature]]) and social environment or childhood experiences ([[Nurture]]). This infers that any distortion in core beliefs will result in deformation of personality. This supports the [[cognitive behavioral therapy]] designed as a management technique for [[personality disorder]]<nowiki/>s, which aims to create an awareness among patients of their [[dysfunctional]] core beliefs and restructure them. <ref name="urlCognitive-Behavioral Theory and Treatment of Antisocial Personality Disorder | IntechOpen">{{cite web |url=http://dx.doi.org/10.5772/intechopen.68986 |title=Cognitive-Behavioral Theory and Treatment of Antisocial Personality Disorder &#124; IntechOpen |format= |work= |accessdate=}}</ref>


====Structural Analysis of Social Behavior (SASB)====
====Structural Analysis of Social Behavior (SASB)====
It is a model to study and analyse different types of social interactions. [[Lorna Smith Benjamin]] developed it using object relations and attachment theory as the basis. It endorses that infants have an [[innate]] desire to form attachments, which are dependent on interactions with caregivers and influence the future relationships of that individual. SASB provides a way to measure these representations using two behavioural dimensions; [[need for affiliation]], and [[need for interdependence]]. They are then plotted [[orthogonally]]. the normal personality is indicated by a circular region closer to intersection point along both axis while rest will be due to personality disorder or inflexible behaviours. Moreover, according to SASB, there are three perspectives to interpret relationship dynamics; self, others and [[introject]]. These influence both the dimensions and hence, each of the dimension is plotted thrice using each of the perspectives.
It is a model to study and analyze different types of social interactions. [[Lorna Smith Benjamin]] developed it using object relations and [[attachment theory]] as the basis. It endorses that infants have an [[innate]] desire to form attachments, which are dependent on interactions with caregivers and influence the future relationships of that individual. SASB provides a way to measure these representations using two behavioral dimensions; [[need for affiliation]], and [[need for interdependence]]. <ref name="pmid8991306">{{cite journal| author=Benjamin LS| title=Introduction to the special section on structural analysis of social behavior. | journal=J Consult Clin Psychol | year= 1996 | volume= 64 | issue= 6 | pages= 1203-12 | pmid=8991306 | doi=10.1037//0022-006x.64.6.1203 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8991306  }} </ref> They are then plotted [[orthogonally]]. the normal personality is indicated by a circular region closer to intersection point along both axis while rest will be due to personality disorder or inflexible behaviors. Moreover, according to SASB, there are three perspectives to interpret relationship [[Dynamics (physics)|dynamics]]; self, others and [[introject]]. These influence both the dimensions and hence, each of the dimension is plotted thrice using each of the perspectives.


===Risk Factors===
===Risk Factors===
It is a well-known fact that personality develops during childhood and interpersonal experiences and social interactions play a significant role in the development of PDs. Parental maltreatment, stress, and traumatic life events influence the personality adversely. In addition, genetic and [[prenatal]] factors also constitute a major role. injuries like trauma, infections like [[encephalitis]], and [[hemorrhage]] may also be contributing factors. Genetic factors interact with environmental stresses to result in PDs. Various parental behavior like excessive attachment, parental insensitivity or emotional neglect, physical and sexual abuse, and [[substance use disorders]] causes an essential impact on PDs development. Social bullying, racial discrimination, frequent dislocations during childhood, and lack of peer support are other risk factors.
It is a well-known fact that [[personality]] develops during childhood and [[interpersonal]] experiences and social interactions play a significant role in the development of PDs. Parental maltreatment, [[Stress (biological)|stress]], and traumatic life events influence the personality adversely. In addition, [[Genetics|genetic]] and [[prenatal]] factors also constitute a major role. injuries like [[trauma]], infections like [[encephalitis]], and [[hemorrhage]] may also be contributing factors. Genetic factors interact with environmental stresses to result in PDs. Various parental behavior like excessive attachment, parental insensitivity or [[emotional]] neglect, [[Physical abuse|physical]] and sexual abuse, and [[substance use disorders]] causes an essential impact on PDs development. Social bullying, racial [[discrimination]], frequent [[dislocations]] during childhood, and lack of [[peer support]] are other risk factors.


==Genetics==
==Genetics==
Genetic factors constitute a major role.  
Genetic factors constitute a major role.  


*Cluster-A PDs can have polymorphisms associated with the gene coding for [[dopamine 2-receptor]] (DRD2), [[catechol-0-methyltransferase]] (COMT), [[Dysbindin]] (DTNBP1), and [[D-aminoacid oxidase]] (DAAO). These genes are also associated with the development of schizophrenia, implying that both [[schizophrenia]] and schizotypal PD are related to [[dopaminergic dysfunction]].  
*Cluster-A PDs can have [[polymorphisms]] associated with the gene coding for [[dopamine 2-receptor]] (DRD2), [[catechol-0-methyltransferase]] (COMT), [[Dysbindin]] (DTNBP1), and [[D-aminoacid oxidase]] (DAAO). These genes are also associated with the development of [[schizophrenia]], implying that both [[schizophrenia]] and [[Schizotypal personality disorder|schizotypal]] PD are related to [[dopaminergic dysfunction]].
*Cluster B PDs have been found linked to polymorphisms in genes encoding serotonin transporter (5-HTTLPR), catabolic enzyme monoamine oxidase (MAOA), and [[tryptophan hydroxylase enzyme]] related genes [[TPH1]] and [[TPH2]]. This demonstrates the relation of the development of [[borderline]] personality and [[antisocial]] disorder with dysfunction in the [[serotonin system]].  
*Cluster B PDs have been found linked to [[polymorphisms]] in genes encoding [[serotonin]] [[transporter]] (5-HTTLPR), catabolic enzyme monoamine oxidase ([[MAOA]]), and [[tryptophan hydroxylase enzyme]] related genes [[TPH1]] and [[TPH2]]. This demonstrates the relation of the development of [[borderline]] personality and [[antisocial]] disorder with dysfunction in the [[serotonin system]].
*Cluster-C PDs are linked with polymorphisms of the [[dopamine 3-receptor]] (DRD3) gene and [[COMT]], particularly [[obsessive-compulsive disorder]]<ref name="pmid20373672">{{cite journal| author=Reichborn-Kjennerud T| title=The genetic epidemiology of personality disorders. | journal=Dialogues Clin Neurosci | year= 2010 | volume= 12 | issue= 1 | pages= 103-14 | pmid=20373672 | doi= | pmc=3181941 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20373672  }} </ref>.
*Cluster-C PDs are linked with polymorphisms of the [[dopamine 3-receptor]] (DRD3) gene and [[COMT]], particularly [[obsessive-compulsive disorder]]<ref name="pmid20373672">{{cite journal| author=Reichborn-Kjennerud T| title=The genetic epidemiology of personality disorders. | journal=Dialogues Clin Neurosci | year= 2010 | volume= 12 | issue= 1 | pages= 103-14 | pmid=20373672 | doi= | pmc=3181941 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20373672  }} </ref>.


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*Substance Use Disorder
*Substance Use Disorder
*Depression
*[[Depression]]
*Anxiety Disorder
*[[Anxiety Disorder]]
 
==Gross Pathology==
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
 
==Microscopic Pathology==
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].


==References==
==References==
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[[Category:Psychiatry]]
[[Category:Psychiatry]]

Latest revision as of 23:10, 13 September 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayesha Anwar, M.B.B.S[2]

Overview

The exact pathogenesis of personality disorder is not fully understood. Personality disorders are related to multifactorial causes. Throughout time, a multitude of theories has been developed to explain the origin of these disorders. However still, the pathophysiology of PDs remains enigmatic. The five-factor model of personality was developed in the 1980s and 1990s, which demonstrated that it comprises five distinct traits. PDs are primarily the result of positive correlation with Neuroticism and negative association with Agreeableness. Extraversion is associated in both ways. It is a well-known fact that personality develops during childhood and interpersonal experiences and social interactions play a significant role in the development of PDs. Parental maltreatment, stress, and traumatic life events influence the personality adversely. In addition, genetic and prenatal factors also constitute a major role. Genetic factors with mutations in genes involving dopamine and serotonin pathways such as DRD2, COMT, DTNBP1, DAAO, 5-HTTLPR, MAOA, DRD3,TPH1 and TPH2. Perinatal injuries like trauma, infections like encephalitis, and hemorrhage may also be contributing factors. Genetic factors interact with environmental stresses to result in PDs. Various parental behavior like excessive attachment, parental insensitivity or emotional neglect, physical and sexual abuse, and substance use disorders causes an essential impact on PDs development. Social bullying, racial discrimination, frequent dislocations during childhood, and lack of peer support are other risk factors.

Pathophysiology

Physiology

The personality development is a dynamic process that starts early in life and continue to evolve and change when subjected to environmental factors and consequential events. It results in establishing an organized pattern of behaviors and attitudes which are unique to every individual.

The theories to explain personality development has been presented throughout time. Freud's Psychoanalytic Theory was the pioneer. As discussed in historical perspectives, it is based on ideas of the id, the ego and the superego.[1] The interaction and conflict among these is responsible for the creating the personality in an individual. He also proposed five stages of psychosexual development. Following it, new-Freudians (followers of Feud) elaborated the concept of Feud to formulate many new theories. However, the major problem was lack of ways to test the theories on wide variety of patients due to differences in dealings by different individuals and due to vague predictions made by it regarding defense mechanisms. Thus, it fails to pass empiricism. The five-factor theory/model is a remarkable widely-accepted model of personality development. It suggests personality constitutes of five traits; Conscientiousness, Agreeableness, Neuroticism, Openness to Experience, and Extraversion. [2] Each personality trait is a spectrum and an individual can fall anywhere on this scale. The other trait theories just utilized binary values instead of a continuum. Each trait is influenced by genetic and environmental factors. The biological theories explain this as well.

Pathogenesis

Throughout time, a multitude of theories has been developed to explain the origin of these disorders. However still, the pathophysiology of PDs remains enigmatic. The five-factor model of personality was developed in the 1980s and 1990s, which demonstrated that it comprises five distinct traits. These include extraversion, Neuroticism, openness to experience/intellect, Agreeableness, and conscientiousness. A meta-analysis conducted by Saulsman and Page in 2004 reveals the association of personality disorders with the five-trait model. It concludes that extraversion is positively associated with disorders characterizing assertiveness or gregariousness like Histrionic and Narcissist. Neuroticism is positively associated with disorders causing emotional distress like Paranoid, Schizotypal, Borderline, Dependent, and Avoidant. Agreeableness is negatively associated with disorders characterized by interpersonal difficulties like Paranoid, Schizotypal, Antisocial, Borderline, and Narcissist. Those disorders which are distinguished by orderliness are positively associated with conscientiousness, like Obsessive-compulsive disorder. Schizoid is negatively associated with extraversion. Hence, PDs are primarily the result of positive correlation with Neuroticism and negative association with Agreeableness. Extraversion is associated in both ways [3]. This remains the most widely accepted explanation for development of personality disorder. Other theories are as follows:

Object Relations Theory of Personality Disorders

Melanie Klein describes that during infant stage of life, each individual develops "internal representations" of self and others. This later results in formulating "self concept" and internal images of other people (objects). This is, in turn, responsible for "affects", which are feelings experienced in presence of others similar to ones previous "representations." The object relations refer to the internal representation of relationship of self and object and these form the building blocks for organizing a person inner personality. [4]

Attachment Theory of Personality Disorder

John Bowlby describes the person's characteristic ways of relating in close relationships. It endorses that every individual develops internal representations of relationships throughout their correspondence with early caretakers. The affective bond between infant and caregiver is responsible for developing interpersonal attitudes and relations. The adaptive attachment of a child with caregiver predicts the intrapsychic conflicts that an individual may experience later in life. This early attachment relations mold an individual to maintain an equilibrium between self regulation and stress regulation. [5]

Cognitive-Behavioral Theory of Personality Disorders

It lays the foundation of CBT which is utilized for treatment of many PDs and other psychiatric conditions these days. It is based on aspect that thoughts are responsible for emotions which predicts the behavior. Core beliefs regarding self and others are formulated which are, in turn, responsible for thoughts, feelings and behavior exhibited by an individual. The theory predicts that the core beliefs are influenced by the biological factors or temperament (Nature) and social environment or childhood experiences (Nurture). This infers that any distortion in core beliefs will result in deformation of personality. This supports the cognitive behavioral therapy designed as a management technique for personality disorders, which aims to create an awareness among patients of their dysfunctional core beliefs and restructure them. [6]

Structural Analysis of Social Behavior (SASB)

It is a model to study and analyze different types of social interactions. Lorna Smith Benjamin developed it using object relations and attachment theory as the basis. It endorses that infants have an innate desire to form attachments, which are dependent on interactions with caregivers and influence the future relationships of that individual. SASB provides a way to measure these representations using two behavioral dimensions; need for affiliation, and need for interdependence. [7] They are then plotted orthogonally. the normal personality is indicated by a circular region closer to intersection point along both axis while rest will be due to personality disorder or inflexible behaviors. Moreover, according to SASB, there are three perspectives to interpret relationship dynamics; self, others and introject. These influence both the dimensions and hence, each of the dimension is plotted thrice using each of the perspectives.

Risk Factors

It is a well-known fact that personality develops during childhood and interpersonal experiences and social interactions play a significant role in the development of PDs. Parental maltreatment, stress, and traumatic life events influence the personality adversely. In addition, genetic and prenatal factors also constitute a major role. injuries like trauma, infections like encephalitis, and hemorrhage may also be contributing factors. Genetic factors interact with environmental stresses to result in PDs. Various parental behavior like excessive attachment, parental insensitivity or emotional neglect, physical and sexual abuse, and substance use disorders causes an essential impact on PDs development. Social bullying, racial discrimination, frequent dislocations during childhood, and lack of peer support are other risk factors.

Genetics

Genetic factors constitute a major role.

Associated Conditions

Conditions associated with personality disorder include:

References

  1. De Sousa A (2011). "Freudian theory and consciousness: a conceptual analysis**". Mens Sana Monogr. 9 (1): 210–7. doi:10.4103/0973-1229.77437. PMC 3115290. PMID 21694972.
  2. Widiger TA, Crego C (2019). "The Five Factor Model of personality structure: an update". World Psychiatry. 18 (3): 271–272. doi:10.1002/wps.20658. PMC 6732674 Check |pmc= value (help). PMID 31496109.
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