Palmar plantar erythrodysesthesia classification: Difference between revisions
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{{Palmar plantar erythrodysesthesia}} | {{Palmar plantar erythrodysesthesia}} | ||
{{CMG}}; {{AE}} {{MC}} | |||
==Overview== | |||
A number of different [[Classification|classifications]] have been used for grading the severity of palmar plantar erythrodysesthesia (PPE). The [[Classification|classifications]] suggested by the [[National Cancer Institute|National Cancer Institute (NCI)]], and the [[World Health Organization|World Health Organization (WHO)]] are the two most commonly used. | |||
==Classification== | |||
* Palmar plantar erythrodysesthesia (PPE) may be [[Classif|classified]] into 3 grades according to the [[National Cancer Institute|National Cancer Institute (NCI)]].<ref name="urlProtocol Development | CTEP">{{cite web |url=https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm |title=Protocol Development | CTEP |format= |work= |accessdate=}}</ref> | |||
{| class="wikitable" | |||
|+Classification of PPE severity according to NCI Common Terminology Criteria for Adverse Events (CTCAE) v5.0 | |||
!GRADES | |||
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!1 | |||
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* Minimal [[skin changes]] (e.g, [[erythema]], [[edema]], or [[hyperkeratosis]]) without [[pain]] | |||
|- | |||
!2 | |||
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* [[Skin changes]] (e.g, peeling, [[Blister|blisters]], [[bleeding]], [[Fissure|fissures]], [[edema]], or [[hyperkeratosis]]) with [[pain]]; limiting instrumental [[Activities of daily living|ADL]] | |||
|- | |||
!3 | |||
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* Severe [[skin changes]] (e.g, peeling, [[Blister|blisters]], [[bleeding]], [[Fissure|fissures]], [[edema]], or [[hyperkeratosis]]) with [[pain]]; limiting self care [[Activities of daily living|ADL]] | |||
|}<br /> | |||
*Palmar plantar erythrodysesthesis (PPE) may be [[Classification|classified]] into 4 grades based on the [[World Health Organization|World Health Organization (WHO)]]. <ref name="pmid11702367">{{cite journal| author=Nagore E, Insa A, Sanmartín O| title=Antineoplastic therapy-induced palmar plantar erythrodysesthesia ('hand-foot') syndrome. Incidence, recognition and management. | journal=Am J Clin Dermatol | year= 2000 | volume= 1 | issue= 4 | pages= 225-34 | pmid=11702367 | doi=10.2165/00128071-200001040-00004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11702367 }} </ref> | |||
{| class="wikitable" | |||
|+Classification of PPE severity according to WHO criteria | |||
!GRADES | |||
! | |||
|- | |||
!1 | |||
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* [[Dysesthesia]]/[[paresthesia]], [[tingling]] in the [[Hand|hands]] and [[feet]] | |||
|- | |||
!2 | |||
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* [[Discomfort]] in holding objects and upon walking, painless [[Edema|swelling]] or [[erythema]] | |||
|- | |||
!3 | |||
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* [[Pain|Painful]] [[erythema]] and [[Edema|swelling]] of [[Palms of the hands|palms]] and [[Sole (foot)|soles]], periungual [[erythema]] and [[Edema|swelling]] | |||
|- | |||
!4 | |||
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* [[Desquamation]], [[Ulcer|ulceration]], [[Blister|blistering]], severe [[pain]] | |||
|} | |||
==Gallery== | |||
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[[Image:PPE grades.png|left|1000px|thumb| '''Palmar–plantar erythrodysesthesia''' <BR> Grades 1–3, according to the National Cancer Institute Common Terminology Criteria for Adverse events, version 4. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576906/figure/MDV244F1/ Images shown above are courtesy of Siegfried Segaert and Eric Van Cutsem]]] | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
<references /> | |||
Latest revision as of 18:58, 4 July 2019
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Palmar plantar erythrodysesthesia Microchapters |
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Differentiating Palmar plantar erythrodysesthesia from other Diseases |
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Diagnosis |
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Treatment |
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Palmar plantar erythrodysesthesia classification On the Web |
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American Roentgen Ray Society Images of Palmar plantar erythrodysesthesia classification |
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Palmar plantar erythrodysesthesia classification in the news |
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Directions to Hospitals Treating Palmar plantar erythrodysesthesia |
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Risk calculators and risk factors for Palmar plantar erythrodysesthesia classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D. [2]
Overview
A number of different classifications have been used for grading the severity of palmar plantar erythrodysesthesia (PPE). The classifications suggested by the National Cancer Institute (NCI), and the World Health Organization (WHO) are the two most commonly used.
Classification
- Palmar plantar erythrodysesthesia (PPE) may be classified into 3 grades according to the National Cancer Institute (NCI).[1]
| GRADES | |
|---|---|
| 1 |
|
| 2 |
|
| 3 |
|
- Palmar plantar erythrodysesthesis (PPE) may be classified into 4 grades based on the World Health Organization (WHO). [2]
| GRADES | |
|---|---|
| 1 |
|
| 2 |
|
| 3 | |
| 4 |
|
Gallery
 Grades 1–3, according to the National Cancer Institute Common Terminology Criteria for Adverse events, version 4. Images shown above are courtesy of Siegfried Segaert and Eric Van Cutsem |
References
- ↑ "Protocol Development | CTEP".
- ↑ Nagore E, Insa A, Sanmartín O (2000). "Antineoplastic therapy-induced palmar plantar erythrodysesthesia ('hand-foot') syndrome. Incidence, recognition and management". Am J Clin Dermatol. 1 (4): 225–34. doi:10.2165/00128071-200001040-00004. PMID 11702367.