Palmar plantar erythrodysesthesia history and symptoms

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Palmar plantar erythrodysesthesia Microchapters

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Overview

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Pathophysiology

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Differentiating Palmar plantar erythrodysesthesia from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D. [2]

Overview

The most common symptoms of PPE include tingling, burning pain, edema, and erythema. Less common symptoms of PPE include sensory impairment, paresthesia, and pruritus.

History and Symptoms

History

Patients with PPE have a positive history of treatment with chemotherapeutic agents.

Common Symptoms

The most common symptoms of PPE include:

  • Periungual skin involvement is also possible
  • The palms of the hands are usually more frequently and more severely affected than the soles of the feet, and may be only are affected.[1] [2]

Less Common Symptoms

Less common symptoms include: [3] [4]

Involvement of other parts of the body is rare, even though mild erythema or morbilliform lesions might occasionally be seen on the trunk, neck, chest, scalp and extremities. [1] [7]

References

  1. 1.0 1.1 1.2 Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
  2. Lassere Y, Hoff P (2004). "Management of hand-foot syndrome in patients treated with capecitabine (Xeloda)". Eur J Oncol Nurs. 8 Suppl 1: S31–40. doi:10.1016/j.ejon.2004.06.007. PMID 15341880.
  3. Hui YF, Cortes JE (2000). "Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin". Pharmacotherapy. 20 (10): 1221–3. PMID 11034047.
  4. "www.oncologynurseadvisor.com".
  5. Hellier I, Bessis D, Sotto A, Margueritte G, Guilhou JJ (1996). "High-dose methotrexate-induced bullous variant of acral erythema". Arch Dermatol. 132 (5): 590–1. PMID 8624164.
  6. Waltzer JF, Flowers FP (1993). "Bullous variant of chemotherapy-induced acral erythema". Arch Dermatol. 129 (1): 43–5. PMID 8420487.
  7. Kroll SS, Koller CA, Kaled S, Dreizen S (1989). "Chemotherapy-induced acral erythema: desquamating lesions involving the hands and feet". Ann Plast Surg. 23 (3): 263–5. PMID 2528937.