Osteocalcin

bone gamma-carboxyglutamate (gla) protein (osteocalcin)
Identifiers
Symbol	BGLAP
Entrez	632
HUGO	1043
OMIM	112260
RefSeq	NM_199173
UniProt	P02818
Other data
Locus	Chr. 1 q25-q31

WikiDoc Resources for Osteocalcin
Articles
Most recent articles on Osteocalcin Most cited articles on Osteocalcin Review articles on Osteocalcin Articles on Osteocalcin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Osteocalcin Images of Osteocalcin Photos of Osteocalcin Podcasts & MP3s on Osteocalcin Videos on Osteocalcin
Evidence Based Medicine
Cochrane Collaboration on Osteocalcin Bandolier on Osteocalcin TRIP on Osteocalcin
Clinical Trials
Ongoing Trials on Osteocalcin at Clinical Trials.gov Trial results on Osteocalcin Clinical Trials on Osteocalcin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Osteocalcin NICE Guidance on Osteocalcin NHS PRODIGY Guidance FDA on Osteocalcin CDC on Osteocalcin
Books
Books on Osteocalcin
News
Osteocalcin in the news Be alerted to news on Osteocalcin News trends on Osteocalcin
Commentary
Blogs on Osteocalcin
Definitions
Definitions of Osteocalcin
Patient Resources / Community
Patient resources on Osteocalcin Discussion groups on Osteocalcin Patient Handouts on Osteocalcin Directions to Hospitals Treating Osteocalcin Risk calculators and risk factors for Osteocalcin
Healthcare Provider Resources
Symptoms of Osteocalcin Causes & Risk Factors for Osteocalcin Diagnostic studies for Osteocalcin Treatment of Osteocalcin
Continuing Medical Education (CME)
CME Programs on Osteocalcin
International
Osteocalcin en Espanol Osteocalcin en Francais
Business
Osteocalcin in the Marketplace Patents on Osteocalcin
Experimental / Informatics
List of terms related to Osteocalcin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753

Please Join in Editing This Page and Apply to be an Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Osteocalcin is a noncollagenous protein found in bone and dentin. It is secreted by osteoblasts and thought to play a role in mineralization and calcium ion homeostasis. It has been stipulated that osteocalcin may also function as a negative regulator of bone formation, although its exact role is unknown.

In August 2007, it was reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin.

Use as a biochemical marker for bone formation

As osteocalcin is manufactured by osteoblasts, it is often used as a biochemical marker, or biomarker, for the bone formation process. It has been routinely observed that higher serum-osteocalcin levels are relatively well correlated with increases in bone mineral density (BMD) during treatment with anabolic bone formation drugs for osteoporosis, such as Forteo. In many studies, Osteocalcin is used as a preliminary biomarker on the effectiveness of a given drug on bone formation.

External links

• Osteocalcin at the US National Library of Medicine Medical Subject Headings (MeSH)