Hippocalcin

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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RefSeq (protein)

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Hippocalcin is a protein that in humans is encoded by the HPCA gene.[1][2]

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.[3][4] It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.[5]

Processes

Hippocalcin takes part in the following processes:

Interactions

Hippocalcin interacts with following proteins:

  • Neuronal apoptosis inhibitory protein (NAIP)
  • Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
  • The b2 adaptin of the AP2 complex
  • Calcium-dependent activator protein for secretion (CADPS)

References

  1. Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. doi:10.1006/bbrc.1994.1491. PMID 8166736.
  2. Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene. 225 (1–2): 117–24. doi:10.1016/S0378-1119(98)00526-5. PMID 9931466.
  3. Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
  4. Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
  5. O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. doi:10.1083/jcb.200306042. PMC 2173692. PMID 14638856.

Further reading

External links


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