Oligomycin

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Oligomycins are macrolides created by Streptomyces that can be poisonous to other organisms.

Function

They have use as antibiotics.

In addition, oligimycin inhibits ATP synthase by blocking its proton channel, which is necessary for oxidative phosphorylation of ADP to ATP (energy production).

Administering oligomycin to an individual can result in very high levels of lactate accumulating in the blood and urine.