Multiple endocrine neoplasia type 2 other imaging findings: Difference between revisions
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{{Multiple endocrine neoplasia type 2}} | {{Multiple endocrine neoplasia type 2}} | ||
{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Other imaging studies for multiple endocrine neoplasia type 2 include fluoro-di-glucose-[[PET]], [18F]-fluorodopamine ([18F]DA) [[PET]], and 99mTc-sestamibi [[scintigraphy]]. | Other imaging studies for multiple endocrine neoplasia type 2 include fluoro-di-glucose-[[PET]], [18F]-fluorodopamine ([18F]DA) [[PET]], and 99mTc-sestamibi [[scintigraphy]]. | ||
==Other Imaging Studies== | ==Other Imaging Studies== | ||
===Medullary Thyroid Carcinoma=== | ===Medullary Thyroid Carcinoma=== | ||
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====I-123 MIBG (metaiodobenzylguanidine)==== | ====I-123 MIBG (metaiodobenzylguanidine)==== | ||
* MIBG (123I- or 131I- metaiodobenzylguanidine) [[scintigraphy]] is another imaging modality for [[pheochromocytoma]] | * MIBG (123I- or 131I- metaiodobenzylguanidine) [[scintigraphy]] is another imaging modality for [[pheochromocytoma]] | ||
====Octreotide (somatostatin) scans==== | ====Octreotide (somatostatin) scans==== | ||
* Over 70% of [[tumor]]s express [[somatostatin]] receptors. Imaging is obtained 4 hours (+/- 24/48 hours) after an [[intravenous infusion]]. Unfortunately the [[kidney]] also has [[somatostatin receptor]]s, as do areas of [[inflammation]], [[mammary gland]]s, [[liver]], [[spleen]], [[bowel]], [[gallbladder]], [[thyroid gland]] and [[salivary gland]]s. As such interpretation can be difficult.<ref>{{cite book | last = Pacak | first = Karel | title = Pheochromocytoma diagnosis, localization, and treatment | publisher = Blackwell Pub | location = Malden, MA Oxford | year = 2007 | isbn = 1405149507 }}</ref> | * Over 70% of [[tumor]]s express [[somatostatin]] receptors. Imaging is obtained 4 hours (+/- 24/48 hours) after an [[intravenous infusion]]. Unfortunately the [[kidney]] also has [[somatostatin receptor]]s, as do areas of [[inflammation]], [[mammary gland]]s, [[liver]], [[spleen]], [[bowel]], [[gallbladder]], [[thyroid gland]] and [[salivary gland]]s. As such interpretation can be difficult.<ref>{{cite book | last = Pacak | first = Karel | title = Pheochromocytoma diagnosis, localization, and treatment | publisher = Blackwell Pub | location = Malden, MA Oxford | year = 2007 | isbn = 1405149507 }}</ref> | ||
* [[Octreotide]] is usually labeled with either 111In-DTPA (Octreoscan) or (less commonly)123I-Tyr3-DTPA. | * [[Octreotide]] is usually labeled with either 111In-DTPA (Octreoscan) or (less commonly)123I-Tyr3-DTPA. | ||
====PET==== | ====PET==== | ||
* 18F Dopa [[PET]] is thought to be highly sensitive according to initial results.<ref name="pmid11818620">{{cite journal| author=Hoegerle S, Nitzsche E, Altehoefer C, Ghanem N, Manz T, Brink I et al.| title=Pheochromocytomas: detection with 18F DOPA whole body PET--initial results.. | journal=Radiology | year= 2002 | volume= 222 | issue= 2 | pages= 507-12 | pmid=11818620 | doi=10.1148/radiol.2222010622 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11818620 }} </ref> | * 18F Dopa [[PET]] is thought to be highly sensitive according to initial results.<ref name="pmid11818620">{{cite journal| author=Hoegerle S, Nitzsche E, Altehoefer C, Ghanem N, Manz T, Brink I et al.| title=Pheochromocytomas: detection with 18F DOPA whole body PET--initial results.. | journal=Radiology | year= 2002 | volume= 222 | issue= 2 | pages= 507-12 | pmid=11818620 | doi=10.1148/radiol.2222010622 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11818620 }} </ref> | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category: | [[Category:Oncology]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 14:32, 21 July 2016
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Multiple endocrine neoplasia type 2 Microchapters |
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Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [4]
Overview
Other imaging studies for multiple endocrine neoplasia type 2 include fluoro-di-glucose-PET, [18F]-fluorodopamine ([18F]DA) PET, and 99mTc-sestamibi scintigraphy.
Other Imaging Studies
Medullary Thyroid Carcinoma
- Radioactive iodine: lesions do not concentrate radioactive iodine since the tumor does not arise from thyroid follicular cells
- FDG-PET: avid uptake
- Tl-201: It has been shown to concentrate Thallium-201[1]
- I-123 MIBG (metaiodobenzylguanidine): 30% of medullary thyroid cancer show uptake if the thyroid is blocked with Lugol solution prior to the scan
Pheochromocytoma
- [18F]-fluorodopamine ([18F]DA) PET is the best imaging modality for pheochromocytoma
I-123 MIBG (metaiodobenzylguanidine)
- MIBG (123I- or 131I- metaiodobenzylguanidine) scintigraphy is another imaging modality for pheochromocytoma
Octreotide (somatostatin) scans
- Over 70% of tumors express somatostatin receptors. Imaging is obtained 4 hours (+/- 24/48 hours) after an intravenous infusion. Unfortunately the kidney also has somatostatin receptors, as do areas of inflammation, mammary glands, liver, spleen, bowel, gallbladder, thyroid gland and salivary glands. As such interpretation can be difficult.[2]
- Octreotide is usually labeled with either 111In-DTPA (Octreoscan) or (less commonly)123I-Tyr3-DTPA.
PET
Parathyroid Carcinoma
- 99mTc-sestamibi scintigraphy is a good imaging modality for hyperparathyroidism.
![Image courtesy of Dr Hani Al Salami[4]](/index.php/File:Nuclear_medicine.jpg)
![Image courtesy of Dr Roberto Schubert[5]](/index.php/File:Nuclear_medicine_02.jpg)
References
- ↑ Talpos GB, Jackson CE, Froelich JW, Kambouris AA, Block MA, Tashjian AH (1985). "Localization of residual medullary thyroid cancer by thallium/technetium scintigraphy". Surgery. 98 (6): 1189–96. PMID 2866591.
- ↑ Pacak, Karel (2007). Pheochromocytoma diagnosis, localization, and treatment. Malden, MA Oxford: Blackwell Pub. ISBN 1405149507.
- ↑ Hoegerle S, Nitzsche E, Altehoefer C, Ghanem N, Manz T, Brink I; et al. (2002). "Pheochromocytomas: detection with 18F DOPA whole body PET--initial results." Radiology. 222 (2): 507–12. doi:10.1148/radiol.2222010622. PMID 11818620.
- ↑ Image courtesy of Dr Hani Al Salami. Radiopaedia (original file[1]).Creative Commons BY-SA-NC
- ↑ Image courtesy of Dr Roberto Schubert. Radiopaedia (original file[2]).Creative Commons BY-SA-NC