Multiple endocrine neoplasia type 2 history and symptoms: Difference between revisions
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* Low muscle mass, sometimes with myopathy | * Low muscle mass, sometimes with myopathy | ||
* Gastrointestinal complaints, especially constipation | * Gastrointestinal complaints, especially constipation | ||
* | * A nodule, [[lump]], or swelling in the neck | ||
* [[Pain]] in the front of the neck | |||
* [[Hoarseness]] or other voice changes | |||
* Trouble swallowing | |||
* Breathing problems | |||
* Continuous [[cough]] | |||
* Symptoms derived from [[pheochromocytoma]] | * Symptoms derived from [[pheochromocytoma]] | ||
* [[Craniosynostosis]] | * [[Craniosynostosis]] | ||
* Dry eyes or lack of tears, which is an especially helpful sign in children | * Dry eyes or lack of tears, which is an especially helpful sign in children | ||
* Delayed puberty | * Delayed puberty |
Revision as of 17:54, 15 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
History
Symptoms
Multiple endocrine neoplasia type 2b
The most common clinical features of MEN2B are:
- Tall, thin, "marfanoid" body build, in which long bones are disproportionately elongated
- Masses beneath mucosal surfaces in the mouth, lips, and eyes. Numerous yellowish-white, sessile, painless nodules on the lips or tongue, with deeper lesions having normal coloration. There may be enough neuromas in the body of the lips to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the sclera and eyelids.
- Low muscle mass, sometimes with myopathy
- Gastrointestinal complaints, especially constipation
- A nodule, lump, or swelling in the neck
- Pain in the front of the neck
- Hoarseness or other voice changes
- Trouble swallowing
- Breathing problems
- Continuous cough
- Symptoms derived from pheochromocytoma
- Craniosynostosis
- Dry eyes or lack of tears, which is an especially helpful sign in children
- Delayed puberty