Multiple endocrine neoplasia type 2 history and symptoms: Difference between revisions

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Revision as of 17:51, 15 September 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

The most common clinical features of MEN2B are:

Tall, thin, "marfanoid" body build, in which long bones are disproportionately elongated
Masses beneath mucosal surfaces in the mouth, lips, and eyes. Numerous yellowish-white, sessile, painless nodules on the lips or tongue, with deeper lesions having normal coloration. There may be enough neuromas in the body of the lips to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the sclera and eyelids.
Low muscle mass, sometimes with myopathy;
Gastrointestinal complaints, especially constipation;
Symptoms derived from medullary carcinoma of the thyroid;
Symptoms derived from pheochromocytoma;
Craniosynostosis;
Dry eyes or lack of tears, which is an especially helpful sign in children;
Delayed puberty

@@ Line 7: / Line 7: @@
 ===Multiple endocrine neoplasia type 2b===
 The most common clinical features of MEN2B are:
-* a tall, thin, "[[Marfan syndrome|marfanoid]]" body build, in which long bones are disproportionately elongated;
+* Tall, thin, "[[Marfan syndrome|marfanoid]]" body build, in which long bones are disproportionately elongated
-* masses beneath mucosal surfaces in the mouth, lips, and eyes (discussed below);
+* Masses beneath mucosal surfaces in the mouth, lips, and eyes. Numerous yellowish-white, sessile, painless nodules on the lips or tongue, with deeper lesions having normal coloration. There may be enough [[neuroma]]s in the body of the lips to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the [[sclera]] and eyelids.
-* low muscle mass, sometimes with myopathy;
+* Low muscle mass, sometimes with myopathy;
-* gastrointestinal complaints, especially constipation;
+* Gastrointestinal complaints, especially constipation;
-* symptoms derived from [[medullary carcinoma of the thyroid]];
+* Symptoms derived from [[medullary carcinoma of the thyroid]];
-* symptoms derived from [[pheochromocytoma]];
+* Symptoms derived from [[pheochromocytoma]];
-* [[craniosynostosis]];
+* [[Craniosynostosis]];
-* dry eyes or lack of tears, which is an especially helpful sign in children;
+* Dry eyes or lack of tears, which is an especially helpful sign in children;
-* delayed puberty.
+* Delayed puberty