Multiple endocrine neoplasia type 2 future or investigational therapies: Difference between revisions
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{{Multiple endocrine neoplasia type 2}} | {{Multiple endocrine neoplasia type 2}} | ||
{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Future or investigational therapies of multiple endocrine neoplasia type 2 include treatment with axitinib, gefitinib, imatinib, motesanib, sorafenib, sunitinib, vandetanib and XL184. | Future or investigational therapies of multiple endocrine neoplasia type 2 include treatment with axitinib, gefitinib, imatinib, motesanib, sorafenib, sunitinib, vandetanib and XL184. | ||
==Future or investigational therapies== | ==Future or investigational therapies== | ||
Further studies on the molecular pathways of c-RET gene and its [[protein]] will help to design novel and more individualized therapeutic modalities based on genetic information. In fact, although the knowledge about mechanisms of [[tumor]] development in patients with multiple endocrine neoplasia type 2 has grown tremendously, much work lies ahead. The final goal is to offer patients with c-RET germline mutations an optimal cancer prevention and treatment program. | Further studies on the molecular pathways of c-RET gene and its [[protein]] will help to design novel and more individualized therapeutic modalities based on genetic information. In fact, although the knowledge about mechanisms of [[tumor]] development in patients with multiple endocrine neoplasia type 2 has grown tremendously, much work lies ahead. The final goal is to offer patients with c-RET germline mutations an optimal cancer prevention and treatment program. | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category: | [[Category:Oncology]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} |
Revision as of 14:34, 21 July 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Future or investigational therapies of multiple endocrine neoplasia type 2 include treatment with axitinib, gefitinib, imatinib, motesanib, sorafenib, sunitinib, vandetanib and XL184.
Future or investigational therapies
Further studies on the molecular pathways of c-RET gene and its protein will help to design novel and more individualized therapeutic modalities based on genetic information. In fact, although the knowledge about mechanisms of tumor development in patients with multiple endocrine neoplasia type 2 has grown tremendously, much work lies ahead. The final goal is to offer patients with c-RET germline mutations an optimal cancer prevention and treatment program. Table below list the major drugs that are being investigated for the treatment of multiple endocrine neoplasia type 2.
Drug | Target molecule |
---|---|
Axitinib | VEGFR, PDGFR beta, C. Kit |
Gefitinib | EGFR |
Imatinib | VEGFR, RET, BCR-ABL |
Motesanib | VEGFR, RET, PDGFR beta, C. Kit |
Sorafenib | VEGFR, RET, RET/PTC, BRAF, PDGFR beta, C. Kit |
Sunitinib | VEGFR, RET, RET/PTC, PDGFR beta |
Vandetanib | VEGFR, RET, RET/PTC, EGFR |
XL184 | VEGFR, RET, PDGFR beta |
Adapted from C. Romei, E. Pardi, F. Cetani, and R. Elisei Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2, Journal of Oncology, vol. 2012, Article ID 705036, 15 pages, 2012. doi:10.1155/2012/705036[1] |
References
- ↑ Romei C, Pardi E, Cetani F, Elisei R (2012). "Genetic and clinical features of multiple endocrine neoplasia types 1 and 2". J Oncol. 2012: 705036. doi:10.1155/2012/705036. PMC 3503399. PMID 23209466.