Middle East respiratory syndrome coronavirus infection history and symptoms: Difference between revisions

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Latest revision as of 00:48, 2 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Symptoms of MERS-CoV typically include high-grade fever, cough, headache, dyspnea, and myalgia. Gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain may also be present.

History and Symptoms

The majority of patients infected with MERS-CoV present with high-grade fever, headache, non-productive cough, dyspnea, and myalgia.
Other symptoms include sore throat, coryza, sputum production, dizziness, nausea and vomiting, diarrhea, and abdominal pain.
Atypical presentations, such afebrile mild respiratory illnesses with diarrhea preceding the development of pneumonia, have been reported.

Common Symptoms

Symptoms associated with MERS are non-specific, with or without multisystem involvement.
- Fever (most common)
- Cough
- Hemoptysis
- Dyspnea
- Myalgia
- Diarrhea
- Sore throat
- Nausea and vomiting
- Chest pain
- Abdominal pain
- Headache
- Runny nose

Neuromuscular manifestations include
- Hypersomnolence
- Weakness
- Tingling in the extremities similar to Guillain-Barré syndrome or virus-related sensory neuropathy.

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{MERS}}
-{{CMG}}
+{{CMG}}; {{AE}} {{Ammu}}
 ==Overview==
+Symptoms of MERS-CoV typically include high-grade [[fever]], [[cough]], [[headache]], [[dyspnea]], and [[myalgia]]. Gastrointestinal symptoms such as [[diarrhea]], [[vomiting]], and [[abdominal pain]] may also be present.
-The most common symptoms at presentation include [[fever]], with or without [[chills]] or [[rigors]], [[cough]], [[shortness of breath]], and [[myalgia]]. Gastrointestinal symptoms such as [[diarrhea]], [[vomiting]], or [[abdominal pain]] are also frequent. [[Acute kidney injury]], [[pericarditis]], and [[disseminated intravascular coagulation]] and other serious complications may occur in some cases.
+==History and Symptoms==
+*The majority of patients infected with MERS-CoV present with high-grade [[fever]], [[headache]], non-productive [[cough]], [[dyspnea]], and [[myalgia]].
+*Other symptoms include [[sore throat]], [[coryza]], [[sputum]] production, [[dizziness]], [[nausea]] and [[vomiting]], [[diarrhea]], and [[abdominal pain]].
+*Atypical presentations, such afebrile mild respiratory illnesses with [[diarrhea]] preceding the development of pneumonia, have been reported.
+===Common Symptoms===
-==History and Symptoms==
+* Symptoms associated with MERS are non-specific, with or without multisystem involvement.
+**[[Fever]] (most common)
+**[[Cough]]
+**[[Hemoptysis]]
+**[[Dyspnea]]
+**[[Myalgia]]
+**[[Diarrhea]]
+**[[Sore throat]]
+**[[Nausea]] and [[vomiting]]
+**[[Chest pain]]
+**[[Abdominal pain]]
+**[[Headache]]
+**[[Runny nose]]
-{|style="float: right; border: 0px; font-size: 90%; margin: 3px;"
+* [[Neuromuscular]] manifestations include
-! style="width: 150px; background: #4479BA"|{{fontcolor|#FFF| '''''Symptom '''''}}
+** Hypersomnolence
-! style="width: 100px; background: #4479BA"|{{fontcolor|#FFF| '''''Percentage '''''}}
+** [[Weakness]]
-|-
+** [[Tingling]] in the extremities similar to [[Guillain-Barré syndrome]] or virus-related sensory [[neuropathy]].
-|  style="background: #F5F5F5"| Fever <br>&nbsp;&nbsp;&nbsp;Fever with chills or rigors
-|  style="background: #F5F5F5"| 98% <br>&nbsp;&nbsp;&nbsp;87%
-|-
-|  style="background: #F5F5F5"| Cough <br>&nbsp;&nbsp;&nbsp;Dry <br>&nbsp;&nbsp;&nbsp;Productive
-|  style="background: #F5F5F5"|83% <br>&nbsp;&nbsp;&nbsp;47% <br>&nbsp;&nbsp;&nbsp;36%
-|-
-|  style="background: #F5F5F5"|Hemoptysis
-|  style="background: #F5F5F5"|17%
-|-
-|  style="background: #F5F5F5"|Shortnes of breath
-|  style="background: #F5F5F5"|72%
-|-
-|  style="background: #F5F5F5"|Chest Pain
-|  style="background: #F5F5F5"|15%
-|-
-|  style="background: #F5F5F5"|Sore throat
-|  style="background: #F5F5F5"|21%
-|-
-|  style="background: #F5F5F5"| Runny Nose
-|  style="background: #F5F5F5"|4%
-|-
-|  style="background: #F5F5F5"| Abdominal Pain
-|  style="background: #F5F5F5"|17%
-|-
-|  style="background: #F5F5F5"| Nausea
-|  style="background: #F5F5F5"|21%
-|-
-|  style="background: #F5F5F5"| Vomiting
-|  style="background: #F5F5F5"|21%
-|-
-|  style="background: #F5F5F5"| Diarrhoea
-|  style="background: #F5F5F5"|26%
-|-
-|  style="background: #F5F5F5"| Myalgia
-|  style="background: #F5F5F5"|32%
-|-
-|  style="background: #F5F5F5"| Headache
-|  style="background: #F5F5F5"|13%
-|}
-Suspect MERS-CoV infection in case of:<br>
+<br />
-* Fever (≥38°C, 100.4°F) and pneumonia or acute respiratory distress syndrome (based on clinical or radiological evidence);<br>
+==References==
-''AND EITHER'' <br>
-* History of travel from countries in or near the Arabian Peninsula1 within 14 days before symptom onset;<br>
+{{reflist|2}}
-''OR''<br>
-* Close contact2 with a symptomatic traveler who developed fever and acute respiratory illness (not necessarily pneumonia) within 14 days after traveling from countries in or near the Arabian Peninsula;<br>
-''OR''<br>
-* Is a member of a cluster of patients with severe acute respiratory illness (e.g. fever and pneumonia requiring hospitalization) of unknown etiology in which MERS-CoV is being evaluated, in consultation with state and local health departments.
-===Symptoms===
+==See Also==
-The table describes the symptoms of [[MERS-CoV]] infection. All but two patients (96%) had one or more chronic medical conditions, including [[diabetes]] (68%), [[hypertension]] (34%), [[heart disease]] (28%), and [[kidney disease]] (49%). Thirty-four (72%) had more than one chronic condition. In a retrospective study on 47 patients with MERS-CoV infection, 42 (89%) needed intensive care and 34 (72%) had mechanical ventilation.<ref name="pmid23891402">{{cite journal| author=Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A et al.| title=Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. | journal=Lancet Infect Dis | year= 2013 | volume= 13 | issue= 9 | pages= 752-61 | pmid=23891402 | doi=10.1016/S1473-3099(13)70204-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23891402  }} </ref> Cases have been reported where patients developed [[acute renal failure]], [[pericarditis]] and [[disseminated intravascular coagulation ]]. <ref name="pmid23782859">{{cite journal| author=Drosten C, Seilmaier M, Corman VM, Hartmann W, Scheible G, Sack S et al.| title=Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. | journal=Lancet Infect Dis | year= 2013 | volume= 13 | issue= 9 | pages= 745-51 | pmid=23782859 | doi=10.1016/S1473-3099(13)70154-3 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23782859  }} </ref>
+* [http://www.who.int/csr/disease/coronavirus_infections/MERS_case_investigation_questionnaire.pdf Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Initial Interview Questionnaire of Cases]
-==References==
+[[Category:Disease]]
-{{Reflist|2}}
-{{WH}}
+[[Category:Virology]]
-{{WS}}
-[[category:disease]]
-[[Category:Infectious disease]]
-[[category:virology]]
 [[Category:Up-To-Date]]

Middle East respiratory syndrome coronavirus infection history and symptoms: Difference between revisions

Latest revision as of 00:48, 2 July 2020

Overview

History and Symptoms

Common Symptoms

References

See Also

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