Menopause laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
[[Laboratory]] findings consistent with the [[diagnosis]] of [[menopause]] include an elevated [[Follicle Stimulating Hormone]] > 40 mIU/mL, decreased [[estradiol]] [[Estrogen|l]]<nowiki/>evel <20 pg/ml, and decreased [[serum]] of the [https://rmanetwork.com/blog/anti-mullerian-hormone-amh-testing-of-ovarian-reserve/#:~:text=Maguire%3A%20AMH%2C%20or%20Anti%2D,a%20woman's%20overall%20egg%20count. Anti-Mullerian Hormone] level < 0.20 ng/ml. In addition to other [[blood tests]] that are related to [[premature menopause]] such as positive [[karyotype]] test of ''[[FMR1]] in [[Fragile X syndrome]] and decrease of [[Thyroid-stimulating hormone]].'' | |||
==laboratory findings== | |||
====Laboratory findings consistent with the diagnosis of menopause include:==== | |||
== | *An elevated [[serum]] of [[Follicle Stimulating Hormone]] ([[FSH]]) > 40 mIU/mL is [[diagnostic]] of [[menopause]], but an elevated [[FSH]] level on two [[Blood tests|blood samples]] is [[diagnostic]] of [[premature menopause]] with intervals of about 4–6 weeks between samples.<ref name="pmid8124478">{{cite journal| author=Burger HG| title=Diagnostic role of follicle-stimulating hormone (FSH) measurements during the menopausal transition--an analysis of FSH, oestradiol and inhibin. | journal=Eur J Endocrinol | year= 1994 | volume= 130 | issue= 1 | pages= 38-42 | pmid=8124478 | doi=10.1530/eje.0.1300038 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8124478 }} </ref> | ||
*A decreased [[serum]] of the [https://rmanetwork.com/blog/anti-mullerian-hormone-amh-testing-of-ovarian-reserve/#:~:text=Maguire%3A%20AMH%2C%20or%20Anti%2D,a%20woman's%20overall%20egg%20count. AMH] level < 0.20 ng/ml is normal in [[Postmenopausal|postmenopausa]]<nowiki/>l [[women|wo]]<nowiki/>[[women|men]], but decreased [[serum]] of the [https://rmanetwork.com/blog/anti-mullerian-hormone-amh-testing-of-ovarian-reserve/#:~:text=Maguire%3A%20AMH%2C%20or%20Anti%2D,a%20woman's%20overall%20egg%20count. Anti-Mullerian Hormone] level is a [[diagnostic test]] of [[premature menopause]]<ref name="pmid22231848">{{cite journal| author=Visser JA, Schipper I, Laven JS, Themmen AP| title=Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency. | journal=Nat Rev Endocrinol | year= 2012 | volume= 8 | issue= 6 | pages= 331-41 | pmid=22231848 | doi=10.1038/nrendo.2011.224 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22231848 }} </ref> | |||
*A decreased [[estradiol]] [[Estrogen|l]]<nowiki/>evel <20 <nowiki/>pg/ml. | |||
*Positive of [[karyotype]] analysis of ''[[FMR1]] in [[Fragile X syndrome]] case.'' | |||
* | *Decrease of [[Thyroid-stimulating hormone]] ([[TSH]]) in [[Thyroid disorders|thyroid dysfunction]] case.<ref name="pmid29225794">{{cite journal| author=Torrealday S, Kodaman P, Pal L| title=Premature Ovarian Insufficiency - an update on recent advances in understanding and management. | journal=F1000Res | year= 2017 | volume= 6 | issue= | pages= 2069 | pmid=29225794 | doi=10.12688/f1000research.11948.1 | pmc=5710309 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29225794 }} </ref> | ||
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== References == | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 05:41, 17 February 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Rahmah Al-Edresi, M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of menopause include an elevated Follicle Stimulating Hormone > 40 mIU/mL, decreased estradiol level <20 pg/ml, and decreased serum of the Anti-Mullerian Hormone level < 0.20 ng/ml. In addition to other blood tests that are related to premature menopause such as positive karyotype test of FMR1 in Fragile X syndrome and decrease of Thyroid-stimulating hormone.
laboratory findings
Laboratory findings consistent with the diagnosis of menopause include:
- An elevated serum of Follicle Stimulating Hormone (FSH) > 40 mIU/mL is diagnostic of menopause, but an elevated FSH level on two blood samples is diagnostic of premature menopause with intervals of about 4–6 weeks between samples.[1]
- A decreased serum of the AMH level < 0.20 ng/ml is normal in postmenopausal women, but decreased serum of the Anti-Mullerian Hormone level is a diagnostic test of premature menopause[2]
- A decreased estradiol level <20 pg/ml.
- Positive of karyotype analysis of FMR1 in Fragile X syndrome case.
- Decrease of Thyroid-stimulating hormone (TSH) in thyroid dysfunction case.[3]
References
- ↑ Burger HG (1994). "Diagnostic role of follicle-stimulating hormone (FSH) measurements during the menopausal transition--an analysis of FSH, oestradiol and inhibin". Eur J Endocrinol. 130 (1): 38–42. doi:10.1530/eje.0.1300038. PMID 8124478.
- ↑ Visser JA, Schipper I, Laven JS, Themmen AP (2012). "Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency". Nat Rev Endocrinol. 8 (6): 331–41. doi:10.1038/nrendo.2011.224. PMID 22231848.
- ↑ Torrealday S, Kodaman P, Pal L (2017). "Premature Ovarian Insufficiency - an update on recent advances in understanding and management". F1000Res. 6: 2069. doi:10.12688/f1000research.11948.1. PMC 5710309. PMID 29225794.