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== '''Overview''' ==
==Overview==
The [[prevalence]] of [[menopause]] is estimated to be about 50 million cases annually. [[Menopause]] naturally occurs in [[women]] between 49 to 52 of [[age]] the [[average]]. The [[Fatality rate|fatality]] cases were 345 cases per 3191 [[women]] aged between 50-86 years in the [[United States]]. There is no [[racial]] predilection to [[Menopause]],  but  African American [[women]] had experienced the largest number of [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms] compared with other [[Ethnic group|ethnic groups]].


==Epidemiology and Demographics==
===Prevalence and Incidence===


*The [[prevalence]] of [[menopause]] is estimated to be about 50 million cases worldwide will go into [[menopause]] annually.<ref name="pmid11716989">{{cite journal| author=Massart F, Reginster JY, Brandi ML| title=Genetics of menopause-associated diseases. | journal=Maturitas | year= 2001 | volume= 40 | issue= 2 | pages= 103-16 | pmid=11716989 | doi=10.1016/s0378-5122(01)00283-3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11716989  }} </ref>


*In 1990 there were 467 million [[postmenopausal]] women in the world, by 2030, [[menopausal]] [[women]] are projected to increase to 1.2 billion worldwide.<ref name="pmid8735350">{{cite journal| author=Hill K| title=The demography of menopause. | journal=Maturitas | year= 1996 | volume= 23 | issue= 2 | pages= 113-27 | pmid=8735350 | doi=10.1016/0378-5122(95)00968-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8735350  }} </ref>
*The [[prevalence]] of [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms] differ in [[women]] according to areas and countries that they live them, the [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms]  ranges from 74% of [[women]] in Europe, 36-50% in North America, 45-69% in [[Latin America]] and 22-63% in Asia.<ref name="pmid20690868">{{cite journal| author=Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P| title=Age of menopause and impact of climacteric symptoms by geographical region. | journal=Climacteric | year= 2010 | volume= 13 | issue= 5 | pages= 419-28 | pmid=20690868 | doi=10.3109/13697137.2010.507886 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20690868  }} </ref>
*The [[prevalence]] of [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms] among [[women]] prescribed [[hormone therapy]] ([[Hormonal therapy|HT]]), the mean age of patients was 54 years. The most common [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms] were: [[hot flushes]] (40 %), [[night sweats]] (17 %), [[insomnia]] (16 %), [[vaginal dryness]] (13 %), [[mood disorders]] (12 %), and [[weight gain]] (12 %).
*85 % of [[postmenopausal]] [[women]] have experienced a [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptom] in their lifetime, and the prevalence of [https://www.contemporaryobgyn.net/view/managing-menopause-part-1-vasomotor-symptoms vasomotor symptoms]( [[hot flushes]] and/or [[night sweats]]) alone is estimated at approximately 40 to 50 million [[women]] in the [[United States]].<ref name="pmid26271251">{{cite journal| author=Sussman M, Trocio J, Best C, Mirkin S, Bushmakin AG, Yood R | display-authors=etal| title=Prevalence of menopausal symptoms among mid-life women: findings from electronic medical records. | journal=BMC Womens Health | year= 2015 | volume= 15 | issue=  | pages= 58 | pmid=26271251 | doi=10.1186/s12905-015-0217-y | pmc=4542113 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26271251  }} </ref>


== '''Epidemiology and Demographics''' ==
<br />
 
===Age===
=== Prevalence and Incidence ===
 
* "About 25 million women pass through menopause each year and were estimated that in 1990 there were 467 million post-menopausal women in the world, with an average age of about 60 years. By 2030, the world population of menopausal and postmenopausal women is projected to increase to 1.2 billion, with 47 million new entrants each year. In the United States, approximately 1.3 million women become menopausal each year".<ref name="pmid8735350">{{cite journal| author=Hill K| title=The demography of menopause. | journal=Maturitas | year= 1996 | volume= 23 | issue= 2 | pages= 113-27 | pmid=8735350 | doi=10.1016/0378-5122(95)00968-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8735350  }} </ref><ref>https://www.ncbi.nlm.nih.gov/books/NBK507826/#article-24984.s11</ref>
*"To assess the prevalence of menopausal symptoms among women prescribed hormone therapy (HT) using electronic medical record data from a regional healthcare organization, the mean age of patients was 54 years. The most common menopausal symptoms were: hot flushes (40 %), night sweats (17 %), insomnia (16 %), vaginal dryness (13 %), mood disorders (12 %), and weight gain (12 %). Among the 102 patients, 163 individual visits listing menopausal symptoms were identified, of which hot flushes (71 visits) were the most common symptom identified. 85 % of postmenopausal women have experienced a menopause-related symptom in their lifetime, and the Prevalence of vasomotor symptoms( hot flushes and/or night sweats) alone is estimated at approximately 40 to 50 million women in the United States".<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542113/#:~:text=With%20the%20aging%20of%20the,the%20year%202030%20%5B1%5D.</ref>
*"Symptomatically of menopause differs in different areas of the world e.g In West - hot flush, in Japan shoulder pain and India low vision are the hallmarks of menopause. HRT use rate is high in the West while it is low or negligible in countries like India".<ref name="pmid15981376">{{cite journal| author=Singh A, Kaur S, Walia I| title=A historical perspective on menopause and menopausal age. | journal=Bull Indian Inst Hist Med Hyderabad | year= 2002 | volume= 32 | issue= 2 | pages= 121-35 | pmid=15981376 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15981376  }} </ref>
 
 


   
*The onset [[age]] of [[menopause]] between the [[Age|ages]] of 50-53 in Europe.
*In North America, the onset [[age]] of [[menopause]] from 50-51years.
*In [[Latin America]], the onset [[age]] of [[menopause]] from 44- 53 years.
*In Asia, the onset [[age]] of [[menopause]] from 42-49 years.<ref name="pmid20690868">{{cite journal| author=Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P| title=Age of menopause and impact of climacteric symptoms by geographical region. | journal=Climacteric | year= 2010 | volume= 13 | issue= 5 | pages= 419-28 | pmid=20690868 | doi=10.3109/13697137.2010.507886 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20690868 }} </ref>


===Age===
===Mortality rate===


*"Menopause is typically beginning between the ages of 51 and 52. However, about 5% of women experience early menopause between the ages of 40 and 45. Additionally, 1% of women experience premature menopause before the age of 40, due to permanent ovarian failure that may be associated with sex chromosome abnormalities".<ref>https://www.ncbi.nlm.nih.gov/books/NBK507826/#article-24984.s11</ref>
*In 1997, the [[Fatality rate|fatality]] cases were 345 cases per 3191 [[women]] aged between 50-86 years in the [[United States]] over a mean follow-up time of 4.0 years.
*"Age at menopause is also higher in the West as compared to the range of 45-47 years in developing countries like India. Historically also a lower age at menopause was range documented in earlier times. This rose to the range of 50-51 years in the present era".<ref name="pmid15981376">{{cite journal| author=Singh A, Kaur S, Walia I| title=A historical perspective on menopause and menopausal age. | journal=Bull Indian Inst Hist Med Hyderabad | year= 2002 | volume= 32 | issue= 2 | pages= 121-35 | pmid=15981376 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15981376 }} </ref>
*The [[Mortality ratio|mortality rate ratio]] ([[Mortality ratio|MRR]]) was 1.50% for [[women]] with [[menopause]] at [[age]] < 40, and the [[Mortality ratio|MRR]] of [[women]] with [[menopause]] at age 40-44 was 1.04%. While the [[Mortality ratio|MRR]] for [[women]] with [[menopause]] at age 45-49 was 0.96%.<ref name="pmid9590601">{{cite journal| author=Cooper GS, Sandler DP| title=Age at natural menopause and mortality. | journal=Ann Epidemiol | year= 1998 | volume= 8 | issue= 4 | pages= 229-35 | pmid=9590601 | doi=10.1016/s1047-2797(97)00207-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9590601 }} </ref>


===Race===


*The [[prevalence]] of [[menopause]] does not vary by race.
*The [[Ethnic group|ethnic]] differences in the [[symptoms]] experienced during the [[menopausal]] transition were noted. Asian [[women]] had experienced the smallest number of [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms] compared with all other [[Ethnic group|ethnic groups]], but  African American [[women]] had experienced the largest number of [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms] compared with other [[Ethnic group|ethnic groups]].<ref name="pmid19245351">{{cite journal| author=Green R, Santoro N| title=Menopausal symptoms and ethnicity: the Study of Women's Health Across the Nation. | journal=Womens Health (Lond) | year= 2009 | volume= 5 | issue= 2 | pages= 127-33 | pmid=19245351 | doi=10.2217/17455057.5.2.127 | pmc=3270699 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19245351  }} </ref>


=== Mortality rate ===
15% increased the risk of causes mortality among women at early age at menopause. The relationship between menopause and mortality is unclear, Increased causes of mortality risk in women that never using postmenopausal hormones with natural menopause at ages <40. This study indicates that HRT use among women who experienced menopause at <45 years of age may increase the risk of mortality, women that are using estrogen and estrogen plus progestin therapy become have more increased risk for stroke. Another review reported a low risk of stroke for oral estrogen use among women who began HRT before age 65.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651856/#:~:text=Increased%20all%2Dcause%20mortality%20risk%20was%20reported%20in%20the%20BWHS,associations%20were%20found%20for%20ever%2D</ref>


=== Race ===


* Data regarding racial differences in age at menopause have been mixed with several small studies reporting that menopause occurs approximately six months earlier in Black women when compared to age-matched White women, while other larger studies have reported no racial difference.




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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Rahmah Al-Edresi, M.D.[2]


Overview

The prevalence of menopause is estimated to be about 50 million cases annually. Menopause naturally occurs in women between 49 to 52 of age the average. The fatality cases were 345 cases per 3191 women aged between 50-86 years in the United States. There is no racial predilection to Menopause, but African American women had experienced the largest number of menopausal symptoms compared with other ethnic groups.

Epidemiology and Demographics

Prevalence and Incidence


Age

Mortality rate

Race





References

  1. Massart F, Reginster JY, Brandi ML (2001). "Genetics of menopause-associated diseases". Maturitas. 40 (2): 103–16. doi:10.1016/s0378-5122(01)00283-3. PMID 11716989.
  2. Hill K (1996). "The demography of menopause". Maturitas. 23 (2): 113–27. doi:10.1016/0378-5122(95)00968-x. PMID 8735350.
  3. 3.0 3.1 Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P (2010). "Age of menopause and impact of climacteric symptoms by geographical region". Climacteric. 13 (5): 419–28. doi:10.3109/13697137.2010.507886. PMID 20690868.
  4. Sussman M, Trocio J, Best C, Mirkin S, Bushmakin AG, Yood R; et al. (2015). "Prevalence of menopausal symptoms among mid-life women: findings from electronic medical records". BMC Womens Health. 15: 58. doi:10.1186/s12905-015-0217-y. PMC 4542113. PMID 26271251.
  5. Cooper GS, Sandler DP (1998). "Age at natural menopause and mortality". Ann Epidemiol. 8 (4): 229–35. doi:10.1016/s1047-2797(97)00207-x. PMID 9590601.
  6. Green R, Santoro N (2009). "Menopausal symptoms and ethnicity: the Study of Women's Health Across the Nation". Womens Health (Lond). 5 (2): 127–33. doi:10.2217/17455057.5.2.127. PMC 3270699. PMID 19245351.


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