Medulloblastoma natural history: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with medulloblastoma may progress to develop ataxia, | If left untreated, patients with medulloblastoma may progress to develop [[ataxia]], [[nystagmus]], and positional [[dizziness]]. Common complications of medulloblastoma include [[hydrocephalus]], [[decerebrate]] attacks, and cranial nerve palsies. Prognosis is generally good, the 5-year survival rate of patients with medulloblastoma is approximately 69%.<ref name="wiki">Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September 25, 2015</ref> | ||
==Natural History== | ==Natural History== | ||
* Most patients with medulloblastoma are initially asymptomatic. If left untreated, most of the patients with medullblastoma will develop [[ataxia]], [[nystagmus]], and positional [[dizziness]] within a few months.<ref name="wiki">Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September 25, 2015</ref> | |||
==Complications== | ==Complications== | ||
*Common complications of medulloblastoma include: | *Common complications of medulloblastoma include: | ||
Revision as of 21:40, 2 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
If left untreated, patients with medulloblastoma may progress to develop ataxia, nystagmus, and positional dizziness. Common complications of medulloblastoma include hydrocephalus, decerebrate attacks, and cranial nerve palsies. Prognosis is generally good, the 5-year survival rate of patients with medulloblastoma is approximately 69%.[1]
Natural History
- Most patients with medulloblastoma are initially asymptomatic. If left untreated, most of the patients with medullblastoma will develop ataxia, nystagmus, and positional dizziness within a few months.[1]
Complications
- Common complications of medulloblastoma include:
- Increased intracranial pressure
- Sixth cranial nerve palsy
- Decerebrate attacks
Prognosis
- Medulloblastoma prognosis is generally good.
- The 5-year survival rate of patients with medulloblastoma is approximately 69%.[1]
- The 10-year survival rate of patients with medulloblastoma is approximately 52%.
- Younger age of a children is associated with worse prognosis.[2]
- The prognosis varies with the molecular subgroup of medulloblastoma, such as:[1]
- Medulloblastoma WNT molecular group is associated with the most favorable prognosis.
- Medulloblastoma SHH molecular group and Group 4 molecular group are associated with an intermediate prognosis.
- Medulloblastoma Group 3 molecular group is associated with a poor prognosis.
References
- ↑ 1.0 1.1 1.2 1.3 Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September 25, 2015
- ↑ Saran FH, Driever PH, Thilmann C, Mose S, Wilson P, Sharpe G; et al. (1998). "Survival of very young children with medulloblastoma (primitive neuroectodermal tumor of the posterior fossa) treated with craniospinal irradiation". Int J Radiat Oncol Biol Phys. 42 (5): 959–67. PMID 9869216.