'''Maltase-glucoamylase, intestinal''' is an enzyme that in humans is encoded by the ''MGAM'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: maltase-glucoamylase (alpha-glucosidase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8972| accessdate = }}</ref><ref name="pmid9446624">{{cite journal |vauthors=Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E | title = Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase | journal = J. Biol. Chem. | volume = 273 | issue = 5 | pages = 3076–81 |date=January 1998 | pmid = 9446624 | doi = 10.1074/jbc.273.5.3076| url = | issn = }}</ref>
'''Maltase-glucoamylase, intestinal''' is an enzyme that in humans is encoded by the ''MGAM'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: maltase-glucoamylase (alpha-glucosidase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8972| accessdate = }}</ref><ref name="pmid9446624">{{cite journal |vauthors=Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E | title = Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase | journal = J. Biol. Chem. | volume = 273 | issue = 5 | pages = 3076–81 |date=January 1998 | pmid = 9446624 | doi = 10.1074/jbc.273.5.3076| url = | issn = }}</ref>
Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers.<ref name="pmid18356321">{{cite journal |vauthors=Quezada-Calvillo R, Sim L, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Robayo-Torres CC, Rose DR, Nichols BL | title = Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit | journal = J. Nutr. | volume = 138 | issue = 4 | pages = 685–92 | year = 2008 | pmid = 18356321 | doi = | url = http://jn.nutrition.org/content/138/4/685.long }}</ref> In the small intestine, this enzyme works in synergy with [[sucrase-isomaltase]] and [[alpha-amylase]] to digest the full range of [[starch|dietary starches]].
Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against [[maltose]], while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers.<ref name="pmid18356321">{{cite journal |vauthors=Quezada-Calvillo R, Sim L, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Robayo-Torres CC, Rose DR, Nichols BL | title = Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit | journal = J. Nutr. | volume = 138 | issue = 4 | pages = 685–92 | year = 2008 | pmid = 18356321 | doi = | url = http://jn.nutrition.org/content/138/4/685.long }}</ref> In the small intestine, this enzyme works in synergy with [[sucrase-isomaltase]] and [[alpha-amylase]] to digest the full range of [[starch|dietary starches]].
Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAMgene.[1][2]
Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers.[3] In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches.
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